The depressurization method is considered to be one of the most promising gas hydrate extraction methods. With the use of a gas hydrate decomposition simulation test system, four gradient depressurization modes and four depressurization intervals were considered under two hydrate saturation conditions, namely, 24−35 and 46−64%, to simulate the borehole pressure and salinity in the test mining location. The findings indicate that the duration of decomposition is influenced by the level of hydrate saturation, with higher saturation resulting in a greater decrease in decomposition time compared to lower saturation levels when subjected to a pressure decline of 3 MPa. Specifically, the decomposition times of Run 2−2a, Run 3−2a, and Run 4−2a at hydrate saturation of 46−64% decrease by 37.57, 21.57, and 43.20%, respectively, in relation to Run 2−1a, Run 3−1a, and Run 4−1a at hydrate saturation of 24−35%. The highest rates of instantaneous hydrate decomposition were observed in the early stages of mining. Within the larger pressure drop, the initial stage of decomposition exhibited a higher rate, while within the lower decrease in pressure interval, the initial stage of decomposition showed a lower rate. Furthermore, the peak instantaneous decomposition rate decreased gradually as the decrease in the pressure gradient increased. The mean speed of hydrate decomposition under the gradient depressurization modes exhibited varying degrees of decrease as the pressure drop gradient increased. Specifically, the average decomposition rates of Run 2−2a, Run 3−2a, and Run 4− 2a fell by 61.27, 64.64, and 69.21%, respectively, compared to those of Run 1−2a. The implementation of gradient depressurization modes has the potential to decrease the likelihood of unforeseen hydrate reformation or cementation, raise the gas efficacy of output, decrease the maximum rate of gas production, bolster the stability of hydrates, and guarantee stability within the reservoir and wellbore.