Permeability of the Blood-Brain Barrier to Long-Chain Alcohols from Plasma

Gelman, Rose A.; Gilbertson, John R.

doi:10.1159/000175592

Cited by 11 publications

(6 citation statements)

References 12 publications

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“…Of particular relevance, the plasmalogens play an important role in cell-cell interactions and gap junctions, and are known to protect against reactive oxygen species [ 37 ]. Further, rodents fed a diet rich in fatty alcohols show elevated plasmalogens in the liver [ 38 ]. Hence, it is interesting to speculate that the decreased abundance of these fatty alcohols in the alcoholic cohort might be a response to the alcohol-induced oxidative stress, causing an increase in the biosynthesis of plasmalogens (thereby a decrease in these particular fecal fatty alcohols).…”

Section: Resultsmentioning

confidence: 99%

Alcohol Induced Alterations to the Human Fecal VOC Metabolome

et al. 2015

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Studies have shown that excessive alcohol consumption impacts the intestinal microbiota composition, causing disruption of homeostasis (dysbiosis). However, this observed change is not indicative of the dysbiotic intestinal microbiota function that could result in the production of injurious and toxic products. Thus, knowledge of the effects of alcohol on the intestinal microbiota function and their metabolites is warranted, in order to better understand the role of the intestinal microbiota in alcohol associated organ failure. Here, we report the results of a differential metabolomic analysis comparing volatile organic compounds (VOC) detected in the stool of alcoholics and non-alcoholic healthy controls. We performed the analysis with fecal samples collected after passage as well as with samples collected directly from the sigmoid lumen. Regardless of the approach to fecal collection, we found a stool VOC metabolomic signature in alcoholics that is different from healthy controls. The most notable metabolite alterations in the alcoholic samples include: (1) an elevation in the oxidative stress biomarker tetradecane; (2) a decrease in five fatty alcohols with anti-oxidant property; (3) a decrease in the short chain fatty acids propionate and isobutyrate, important in maintaining intestinal epithelial cell health and barrier integrity; (4) a decrease in alcohol consumption natural suppressant caryophyllene; (5) a decrease in natural product and hepatic steatosis attenuator camphene; and (6) decreased dimethyl disulfide and dimethyl trisulfide, microbial products of decomposition. Our results showed that intestinal microbiota function is altered in alcoholics which might promote alcohol associated pathologies.

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Section: Resultsmentioning

confidence: 99%

Alcohol Induced Alterations to the Human Fecal VOC Metabolome

et al. 2015

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“…This mechanism, however, may be limited to controlling physiologic levels of plasmalogens in only some cells or tissues. In cultured SLS keratinocytes, which accumulate fatty alcohol, neutral ether lipids (1- O -alkyl-diacylglycerols) are increased but plasmalogen levels are minimally affected [33], whereas rodents fed large amount of fatty alcohol show elevated plasmalogens in liver [84]. …”

Section: Fatty Alcohol Metabolismmentioning

confidence: 99%

“…Fatty alcohols [84,107] and wax esters [108] are present in a variety of vegetables and fruits. Farnesol is present in certain essential oils and is occasionally used as a food additive.…”

Section: Dietary Sources Of Fatty Aldehydes and Alcoholsmentioning

confidence: 99%

Fatty aldehyde and fatty alcohol metabolism: Review and importance for epidermal structure and function

Rizzo

2014

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

101

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Normal fatty aldehyde and alcohol metabolism is essential for epidermal differentiation and function. Long-chain aldehydes are produced by catabolism of several lipids including fatty alcohols, sphingolipids, ether glycerolipids, isoprenoid alcohols and certain aliphatic lipids that undergo α- or ω-oxidation. The fatty aldehyde generated by these pathways is chiefly metabolized to fatty acid by fatty aldehyde dehydrogenase (FALDH, alternately known as ALDH3A2), which also functions to oxidize fatty alcohols as a component of the fatty alcohol:NAD oxidoreductase (FAO) enzyme complex. Genetic deficiency of FALDH/FAO in patients with Sjögren-Larsson syndrome (SLS) results in accumulation of fatty aldehydes, fatty alcohols and related lipids (ether glycerolipids, wax esters) in cultured keratinocytes. These biochemical changes are associated with abnormalities in formation of lamellar bodies in the stratum granulosum and impaired delivery of their precursor membranes to the stratum corneum (SC). The defective extracellular SC membranes are responsible for a leaky epidermal water barrier and ichthyosis. Although lamellar bodies appear to be the pathogenic target for abnormal fatty aldehyde/alcohol metabolism in SLS, the precise biochemical mechanisms are yet to be elucidated. Nevertheless, studies in SLS highlight the critical importance of FALDH and normal fatty aldehyde/alcohol metabolism for epidermal function.

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“…Uważa się że absorpcja długołańcuchowych alkoholi alifatycznych podawanych dożołądkowo zależy od długości łańcucha. W odniesieniu do bariery krew-mózg potencjał ten jest wprost proporcjonalny do długości łańcucha (Gelman 1975). Biorąc pod uwagę biotransformację alkoholi i właściwości fizykochemiczne odpowiednich kwasów karboksylowych, zdolność do eliminacji do mleka kobiecego uważa się za niską.…”

Section: Toksykokinetyka / Toxicokineticsunclassified

1. Dekan-1-ol i jego izomery. Dokumentacja proponowanych dopuszczalnych wielkości narażenia zawodowego

Szymańska¹,

Frydrych²

2021

PiMOSP

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Dokumentacja proponowanych dopuszczalnych wielkości narażenia zawodowego 1,2 1-Decanol and its isomers: 2-decanol, 3-decanol, 4-decanol, 5-decanol Documentation of proposed values of occupational exposure limits (OELs) 1,2 1 Wartości NDS i NDSCh dekan-1-olu i jego izomerów zostały w dniu 22.03.2021 r. przyjęte na 98. posiedzeniu Międzyresortowej Komisji do spraw Najwyższych Dopuszczalnych Stężeń i Natężeń Czynników Szkodliwych dla Zdrowia w Środowisku Pracy i następnie zostały przedłożone ministrowi właściwemu do spraw pracy (wniosek nr 114) w celu ich wprowadzenia do rozporządzenia w załączniku nr 1 w części A wykazu najwyższych dopuszczalnych stężeń i natężeń czynników szkodliwych dla zdrowia w środowisku pracy. The level of TLV and STEL values of 1-decanol and its isomers were adopted on 22.03.2021 at the 98 th meeting of the Interdepartamental Commission for Threshold Limit Values and Intensities for Agents Harmful to Health in the Working Environment and were submitted to the Minister for Development, Work and Technology (application No. 114) for their introduction to the Regulation in Annex 1, Part A, of the list of threshold limit values and intensities of agents harmful to health in the working environment. 2 Opracowano na podstawie wyników V etapu programu wieloletniego "Poprawa bezpieczeństwa i warunków pracy", finansowanego w zakresie badań naukowych i prac rozwojowych ze środków Narodowego Centrum Badań i Rozwoju (projekt nr II.PB.03 pt.: Opracowanie dokumentacji dopuszczalnych poziomów narażenia zawodowego dla 30 czynników chemicznych szkodliwych dla zdrowia, w tym rakotwórczych). Koordynator programu: Centralny Instytut Ochrony Pracy -Państwowy Instytut Badawczy. This paper has been based on the results of a research task carried out within the scope of the fifth stage of the National Programme "Improvement of safety and working conditions" within the scope of research and development by the National Centre for Research and Development (task No. II.PB.03: Development of documentations of proposed values of occupational exposure limits for 30 chemical agents harmful to health, including carcinogens). The Central Institute for Labour Protection -National Research Institute is the Programme's main co-ordinator. NDS / TLV (threshold limit value)30 mg/m 3 NDSCh / STEL (short-term exposure limit) 60 mg/m 3 NDSP / TLV-C (threshold limit value -ceiling) nie ustalono/not determined DSB / BLV (biological limit value) nie ustalono/not determined I substancja o działaniu drażniącym / irritating agent Data zatwierdzenia przez Zespół Ekspertów / Date of approval by the Expert Team: 28-29.10.2020 r. Data zatwierdzenia przez Komisję ds. NDS i NDN / Date of approval by the Commission for TLV and PEL: 22.03.2021 r.

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Permeability of the Blood-Brain Barrier to Long-Chain Alcohols from Plasma

Cited by 11 publications

References 12 publications

Alcohol Induced Alterations to the Human Fecal VOC Metabolome

Alcohol Induced Alterations to the Human Fecal VOC Metabolome

Fatty aldehyde and fatty alcohol metabolism: Review and importance for epidermal structure and function

1. Dekan-1-ol i jego izomery. Dokumentacja proponowanych dopuszczalnych wielkości narażenia zawodowego

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