“…In the case of chitosan, the amino groups of the polymer may allow the establishment of different types of interactions with both non-ionic and ionic drugs [123] and also provide pH-sensitive systems, which swell in gastric conditions allowing site-specific release [124]. Several cross-linking reagents have been used for crosslinking of chitosan, such as glutaraldehyde, genipin, ethylene glycol, diglycidyl ether and diisocyanate [125][126][127][128][129].…”