Permeation Analysis of Novel Steroid Vehicles to Deliver and Retain Steroid in Skin Layers Associated with Psoriasis

Abstract

The F-C formulation had the highest retention of betamethasone in the skin and the highest 12-hour and 24-hour permeation of betamethasone through the skin into the receptor fluid.The F-10 formulation had the second highest retention of betamethasone in total skin and relatively low permeation of betamethasone into the receptor fluid (Figure 2).The F-10 formulation had skin layer betamethasone concentrations of 33 ng, 18 ng, and 14 ng in the stratum corneum, epidermis, and dermis, respectively (Figure 1).The skin layer concentrations of the F-C formulation were 37 ng, 43 ng, and 34 ng, and those of the F-A formulation were 5 ng, 17 ng, and 14 ng in the stratum corneum, epidermis, and dermis (Figure 1).

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“…2.5-5.0 mg/kg/day two doses per day, if hypertension or renal impairment that is there then dose gets decreased to 0.5-1.0 mg/kg. US FDA has an approval for1 year of regular treatment [59][60][61][62][63][64] .…”