Permeation of skin with (C₆₀) fullerene dispersions

Abstract

Dispersions in transcutol/isopropyl myristate make C 60 fullerene molecules suitable for transdermal delivery. We found that C 60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropyl myristate without harsh organic solvents show a high potential for delivery of C 60 for biopharmaceutical and cosmetics applications.

Drug/Vehicle Impacts and Formulation Centered Stratagems for Enhanced Transdermal Drug Permeation, Controlled Release and Safety: Unparalleled Past and Recent Innovations-An Overview

“…These hydrophobic orbicular structures of 1nm dimensions possess hollow interior, can be improved as water-soluble segments by appending the hydrophilic moieties through covalent functionalization or encapsulation of cyclodextrin or polyvinylpyrrolidone, etc. [116,117]. There were few research reports in the recent past with reference to the carbon-based nanomaterials as skin drug delivery systems which laid emphasis on further exploration.…”

Supramolecular Chromatographic Separation of C60 and C70 Fullerenes: Flash Column Chromatography vs. High Pressure Liquid Chromatography

“…Since the discovery of fullerenes in 1985 [ 1 , 2 ], there has been an ever increasing scientific and industrial interest in fullerenes due to their remarkable electronic and optoelectronic properties, charge transfer ability, efficient singlet oxygen sensitising ability, strong electron acceptor character, and superconductivity upon doping with alkali metals. These properties make fullerenes and their derivatives particularly useful in the development of biosensors [ 3 , 4 ], skin preparation and cosmetics [ 5 , 6 ], and a range of other medical applications [ 7 , 8 ]. Fullerenes-based nanomaterials have great potential for a plethora of biomedical applications but are limited by the high cost and difficulties in purification.…”

Effect of fullerene nanoemulsion on the repair of wrinkles induced by UVB radiation: A c57bl6 mice model

“…Antioxidants are used to protect skin aging as a result of topical application or diet 4 . Fullerenes nanoemulsions are a powerful free radical scavenger that has the potential to protect and regenerate against reactive oxygen species that stimulate collagen degradation 5 …”