Permissive/Protective Interplay of Microbiota with T Cell Adaptive Immune Response in Colon Cancer

Abstract

Colon microbiota, as a complex and diverse population, has been shown to be either pro-or anti-tumorigenic, depending on its content. The composition of microbiota critically determines the differentiation, activation, and expansion of T cells by which proor anti-tumorigenic effects of microbes are frequently reported to be mediated. In this review study, we specified an imbalance in microbiota and T cells in particular regulatory T cells and Th17 cells in colon cancer. We also aimed to discuss evidence, suggesting the contribution of microbiota to carcinogenesis or anti-carcinogenesis through influencing T cells.