Permissivness of human embryo liver cells for HIV infection

Development of the system for gene therapy of AIDS on the basis of antisense RNAs

“…The reduction in antigen production by 66 % and the infectious titer of HIV by 99 %, compared to the cultures without antisense constructions, was observed while determining the virus titer and its production of antigen p24 in the population of cells, transfected with antisen- [14] se plasmid and cultivated in the presence of selective antibiotic. The reduction in the infectious titer of the virus (by two orders) is a decisive index of inhibitory effect, but the synthesis rate of virus-specific protein p24 in our experiments could be estimated with less optimism.…”