Permselective Ultra-Thin Disposable Silicone Rubber Membrane Blood Oxygenator

Esmond, William G.; Dibelius, N. R.

doi:10.1097/00002480-196504000-00060

Cited by 12 publications

(2 citation statements)

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“…The first group of rats was exposed to hypoxia of 4 weeks duration. Rats, kept in individual cages, were housed in a large 'hypoxic cage', an airtight plastic cage with walls partially replaced with dimcthylsilicone rub ber membranes (General Electric, Schenectady, N.Y.) with defined permeability for O2 and CO2 [4]. The number of rats in the hypoxic cage was adjusted so that PO2 was around 55 mm Hg, while PCO2 was controlled by a carbon dioxide adsorber.…”

Section: Methodsmentioning

confidence: 99%

Decreased Pulmonary Pressor Response to Acute Hypoxia in Chronically Hypoxic Rats

Sušić¹,

Haxhiu²,

Kentera³

1981

Respiration

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The pulmonary vascular response to an acute hypoxic stimulus was examined in rats which were kept for 4 weeks in a hypoxic environment and compared to that of rats kept in a normoxic environment. To this end, the effects of breathing gas mixtures containing 7, 21 and 100% O₂ on right ventricular systolic pressure (RVPs), cardiac output (Q) and calculated pulmonary vascular resistance (PVR) in chronically hypoxic (CH) rats and rats kept in a normoxic environment (N) were examined. During breathing of 21% O₂ the RVPs, Q, and PVR were all higher in CH than in N rats. Breathing a gas mixture containing 7% O₂ had no effect on systemic blood pressure, heart rate or Q, in both CH and N rats. When compared to breathing of 21% O₂, the RVP and PVRremained unchanged in CH rats breathing 7% O₂, while both variables significantly (p < 0.01) increased in N rats. The presented data indicate that the reaction of the pulmonary vasculature to an hypoxic challenge is decreased in CH rats.

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Section: Methodsmentioning

confidence: 99%

Decreased Pulmonary Pressor Response to Acute Hypoxia in Chronically Hypoxic Rats

Sušić¹,

Haxhiu²,

Kentera³

1981

Respiration

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show abstract

“…10 Walter Robb, then at General Electric, showed that dimethyl silicone rubber could provide good permeability and a good permeability ratio between carbon dioxide and oxygen, given the different partial pressures in normal blood. 11 General Electric advertised this result as a promotion for their research, using a hamster cage, with walls of silicone rubber, submerged in a fish tank, where the hamster could breath comfortably even though his cage was under water, as gases diffused into and from the water. Several developers and manufacturers adopted this new material, the Landé -Edwards, 12 the Travenol Modulung, 13 and the Sci-Med based on the Kolobow spiral coil design.…”

Section: Early Commercial Devicesmentioning

confidence: 99%