Pernicious Anemia and the Early Diagnosis of Tumors of the Stomach

Increased incidence of pancreatic neoplasia in pernicious anemia

“…The relationship between PA and gastric neoplasia has been studied extensively and, no doubt, these patients are at special risk of developing gastric neoplasia [1][2][3][4][5][6]15]. The majority of studies concerning the relationship between PA and gastric neoplasia were published from the 1930's to the 1960's.…”

“…It is well established that achlorhydric atrophic gastritis associated with pernicious anemia (PA) is a premalignant condition with regard to gastric neoplasia development [1][2][3][4][5][6]. In addition to metaplastic and proliferative mucosal changes, pathologic colonization with bacterial species able to enhance N-nitrosamine formation are factors considered to be important in the carcinogenesis of the achlorhydric stomach [7][8][9].…”

Carcinoma of the stomach. A review of 161 cases treated at the new haven hospital from January, 1941, to December, 1946, and a comparison with two previous series, 1920-1930 and 1931-1940

“…22 T h e suggestion has been made that total gastrectomy might be indicated for all patients with operable carcinoma of the stomach.14. 15 T h e data given here for a series in which almost all resections were subtotal (thirty-nine of forty curative resections) indicate that a significant group of five-year survivors can be obtained by radical subtotal resection.…”

Inflation of the Stomach With Double Contrast

“…The role of the gastric polyp as a precursor of carcinoma is widely accepted; the literature on this subject has been previously reviewed. 5 In patients with pernicious anemia, particularly, the importance of this statement cannot be discounted. It is true that many small polyps of the stomach never change in size or characteristics, but there is no means available at present for determining which will remain unchanged.…”