Peromyscus leucopus

Lackey, James Alden; Huckaby, David G.; Ormiston, Brian G.

doi:10.2307/3503904

Cited by 108 publications

(62 citation statements)

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“…The primary reservoir for B. burgdorferi in the eastern United States is the white-footed mouse, Peromyscus leucopus (27), which once infected probably remains so for life (41,67) with no apparent mortality as a result (14,41). However, these mice are relatively short-lived, and wild populations usually have a complete turnover and replacement with young each year (47), although rare individuals may live long enough to overwinter into the next spring (14,62). The primary tick vector associated with these mice, I. scapularis, has a 2-year life cycle (23).…”

Section: Discussionmentioning

confidence: 99%

Variable Tick Protein in Two Genomic Groups of the Relapsing Fever Spirochete Borrelia hermsii in Western North America

et al. 2005

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Borrelia hermsii is the primary cause of tick-borne relapsing fever in North America. When its tick vector, Ornithodoros hermsi, acquires these spirochetes from the blood of an infected mammal, the bacteria switch their outer surface from one of many bloodstream variable major proteins (Vmps) to a unique protein, Vtp (Vsp33). Vtp may be critical for successful tick transmission of B. hermsii; however, the gene encoding this protein has been described previously in only one isolate. Here we identified and sequenced the vtp gene in 31 isolates of B. hermsii collected over 40 years from localities throughout much of its known geographic distribution. Seven major Vtp types were found. Little or no sequence variation existed within types, but between them significant variation was observed, similar to the pattern of diversity described for the outer surface protein C (OspC) gene in Lyme disease spirochetes. The pattern of sequence relatedness among the Vtp types was incongruent in two branches compared to two genomic groups identified among the isolates by multilocus sequence typing of the 16S rRNA, flaB, gyrB, and glpQ genes. Therefore, both horizontal transfer and recombination within and between the two genomic groups were responsible for some of the variation observed in the vtp gene. O. hermsi ticks were capable of transmitting spirochetes in the newly identified genomic group. Therefore, given the longevity of the tick vector and persistent infection of spirochetes in ticks, these arthropods rather than mammals may be the likely host where the exchange of spirochetal DNA occurs.

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Section: Discussionmentioning

confidence: 99%

Variable Tick Protein in Two Genomic Groups of the Relapsing Fever Spirochete Borrelia hermsii in Western North America

et al. 2005

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“…Both rodents of this study (white-footed mouse, Peromyscus leucopus Rafinesque; and northern grasshopper mouse, Onychomys leucogaster Wied-Neuwied) are somewhat omnivorous, but specialize on protein-rich diets more than many rodents; grasshopper mice in particular are unique amongst North American rodents in having a diet composed primarily of arthropods and vertebrates (Martin and Nelson, 1951;McCarty, 1978;Lackey et al, 1985). Myotis lucifugus were captured in Dane County, Wisconsin, near night roosts using mistnets and were used in experiments within 12 h of capture (Table 1).…”

Section: Animalsmentioning

confidence: 99%

Paracellular nutrient absorption is higher in bats than rodents: integrating from intact animals to the molecular level

Price

Rott

Caviedes‐Vidal

et al. 2014

Journal of Experimental Biology

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Flying vertebrates have been hypothesized to rely heavily on paracellular absorption of nutrients to compensate for having smaller intestines than non-flyers. We tested this hypothesis in an insectivorous bat (Myotis lucifugus) and two insect-eating rodents (Onychomys leucogaster and Peromyscus leucopus). In intact animals, the fractional absorption of orally dosed L-arabinose (M r 150) was 82% in M. lucifugus, which was more than twice that of the rodents. Absorption of creatinine (M r 113) was greater than 50% for all species and did not differ between M. lucifugus and the rodents. We also conducted intestinal luminal perfusions on anesthetized animals. Absorption of L-arabinose per nominal surface area in M. lucifugus was nearly double that of the rodents, while absorption of creatinine was not different among species. Using an everted sleeve preparation, we demonstrated that high concentrations of L-arabinose and creatinine did not inhibit their own uptake, validating their use as passive, paracellular probes. Histological measurements indicated that M. lucifugus has more cells, and presumably more tight junctions, per nominal surface area than P. leucopus. This seems unlikely to explain entirely the higher absorption of L-arabinose in M. lucifugus during perfusions, because L-arabinose absorption normalized to the number of enterocytes was still double that of P. leucopus. As an alternative, we investigated tight junction gene expression. M. lucifugus had higher expression of claudin-1 and claudin-15, and lower expression of claudin-2 relative to P. leucopus. Expression of claudin-7 and occludin did not differ among species. Taken together, our results support the hypothesis that bats have evolved higher paracellular nutrient absorption than non-flying animals, and that this phenomenon might be driven by both histological characteristics and differences in tight junction gene expression.

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“…An abundant species in many of the habitats it occupies, the white-footed mouse is ecologically significant as an insect and seed predator, as well as prey for larger animals (Hall 1981, Lackey et al 1985, Whitaker & Hamilton 1998. It is also important to human health as a reservoir species for the New York virus, a cause of hantavirus pulmonary syndrome in humans, and for the spirochaete Borrelia burgdorferi, which causes Lyme disease (Centers for Disease Control and Prevention 2002, Bunikis & Barbour 2005).…”

mentioning

confidence: 99%

Shippingport, Kentucky, is the type locality for the white-footed mouse,Peromyscus leucopus(Rafinesque, 1818) (Mammalia: Rodentia: Cricetidae)

Woodman

2015

Proceedings of the Biological Society of Washington

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Peromyscus leucopus

Cited by 108 publications

References 0 publications

Variable Tick Protein in Two Genomic Groups of the Relapsing Fever Spirochete Borrelia hermsii in Western North America

Variable Tick Protein in Two Genomic Groups of the Relapsing Fever Spirochete Borrelia hermsii in Western North America

Paracellular nutrient absorption is higher in bats than rodents: integrating from intact animals to the molecular level

Shippingport, Kentucky, is the type locality for the white-footed mouse,Peromyscus leucopus(Rafinesque, 1818) (Mammalia: Rodentia: Cricetidae)

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