Peroxidação lipídica e obesidade: Métodos para aferição do estresse oxidativo em obesos

França, Bruna Cristiane Souza; Alves, Maria Rosa Melo; Souto, Fernanda Maria Silveira; Tiziane, Larissa; Boaventura, Raquel Freire; Guimarães, Adriana Coutinho de Azevedo; Alves, Antonio

doi:10.1016/j.jpg.2013.04.002

Cited by 32 publications

(32 citation statements)

References 44 publications

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“…3,4 Obesity also affects the mitochondrial metabolism, which favors the production of reactive oxygen species (ROS), as well as the development of oxidative stress. 5 According to the mechanism responsible for ROS occurrence, the intracellular triglycerides inhibit the movement of adenosine nucleotides and lead to adenosine triphosphate (ATP) accumulation, as well as to mitochondrial adenosine diphosphate (ADP) decrease. It reduces the oxidative phosphorylation rate and enables the release of electrons and free radicals, which, in turn, results in the production of reactive species (ROS) that damage tissues and cells.…”

Section: Introductionmentioning

confidence: 99%

“…Roux-en-Y gastric bypass is the most effective procedure and is recommended as the gold standard to treat comorbid conditions related to morbid obesity. 5,13 Its main benefits to patients are early satiety center stimulation and improvement of the metabolic syndrome cycle with 75% effective decrease in the initial excess weight. 14 Vitamin supplementation is essential to prevent nutritional deficiencies resulting from the surgical procedure, as well as to achieve healthy weight reduction.…”

Section: Introductionmentioning

confidence: 99%

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Obesity, bariatric surgery and oxidative stress

Horn

Gelatti

Mori

et al. 2017

Rev. Assoc. Med. Bras.

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Introduction: Obesity refers to the accumulation of fatty tissues and it favors the occurrence of oxidative stress. Alternatives that can contribute to body weight reduction have been investigated in order to reduce the production of reactive oxygen species responsible for tissue damage. The aim of the current study was to assess whether the oxidant and antioxidant markers of obese women before and after bariatric surgery were able to reduce oxidative damage. Method:We have assessed 16 morbidly obese women five days before and 180 days after the surgery. The control group comprised 16 non-obese women. Levels of thiobarbituric acid-reactive substances, carbonylated proteins, reduced glutathione and ascorbic acid were assessed in the patients' plasma. Results: Levels of lipid peroxidation and protein carbonylation in the pre-surgical obese women were higher than those of the controls and post-surgical obese women. Levels of reduced glutathione in the pre-surgical obese women were high compared to the controls, and declined after surgery. Levels of ascorbic acid fell in the pre--surgical obese women compared to the control and post-surgical obese women. Conclusion: Body weight influences the production of reactive oxygen species. Bariatric surgery, combined with weight loss and vitamin supplementation, reduces cellular oxidation, thus reducing tissue damage.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Obesity, bariatric surgery and oxidative stress

Horn

Gelatti

Mori

et al. 2017

Rev. Assoc. Med. Bras.

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“…Among these, it is highlighted that lipid peroxidation is a chain reaction of the fatty acids from cell membranes, capable of generating free radicals that cause damage to cells and which is increased in obesity. In addition, the decrease of cytoprotective enzymes with obesity has also been related to cellular damage and, consequently, to the development of chronic non-transmissible diseases, such as cancer, atherosclerosis, hypertension, among others 7 . However, it is noteworthy that, recently, evidence has emerged showing that not only insufficient or excessive food consumption, but the quality of the diet, is related to the definition of health status 8 , as well as nutritional status 9 .…”

Section: Introductionmentioning

confidence: 99%

Avaliação da ingestão de nutrientes antioxidantes pela população brasileira e sua relação com o estado nutricional

Tureck

Locateli

Corrêa

et al. 2017

Rev. bras. epidemiol.

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Introduction:The study of dietary antioxidants has gained prominence owing to the elucidation of the deleterious effects of oxidative stress to the human body. Objective: To evaluate the Brazilian population's intake of antioxidant nutrients and their association with the nutritional status. Methods: A cross-sectional study was carried out including secondary data on food consumption of 33,459 individuals from both sexes, aged 10 years or older, from all Brazilian regions based on microdata of the "2008-2009 Household Budget Survey, Brazilian Dairy Survey." The content of vitamins E, A, and C; zinc; manganese; copper; and selenium from 188 food items, divided into 12 groups, according to the habitual consumption form was analyzed. The means of antioxidant nutrient intake according to the nutritional status were compared using Bonferroni's t-test. Results: Higher percentages of insufficient intake of vitamins than antioxidant minerals were seen. A significant difference in the intake of vitamin E as to the nutritional status was noticed, wherein the intake in overweight individuals was lower than in those with proper weight. Participants with low weight presented lower intake of almost all antioxidant minerals, except for copper, in which the intake of participants with low weight was equal to those with normal weight. Conclusion: High percentages of insufficient intake of antioxidant nutrients were observed in the studied population, especially vitamins. It was also found that the intake of antioxidant nutrients varied based on nutritional status, gender, and life stage.

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“…These metabolites, even at low concentrations, can contribute to the high antioxidant potential of plant species (Savini et al, 2013), mainly due to the presence of conjugated double bonds, hydroxyl groups at C4 and C3 and the catechol group in ring B (Degáspari and Waszczynskyj, 2004) in their structures, making them targets of attack by free radicals, with displacement of the electron cloud around the aromatic ring (França et al, 2013) and electron donation, thereby blocking the phase propagation of chain reactions (Halliwell, 2001) and giving greater stability to the radical form.…”

Section: Resultsmentioning

confidence: 99%

Stem bark extracts of Endopleura uchi (Huber) Cuatrec: Inhibition of pancreatic lipase and antioxidant activity

Gustavo¹,

Anderson²,

Luciana³

et al. 2017

J. Med. Plants Res.

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Pancreatic lipase is considered an important target for the control of hyperlipidemia. Several plants, especially those rich in phenolic metabolites, have been shown to have anti-hyperlipidemic activity and are considered a good alternative for obesity prevention. Extracts of the stem bark of Endopleura uchi (Huber) Cuatrec (Humiriaceae) were evaluated for the inhibitory activity on the pancreatic lipase enzyme, as well as their antioxidant potential were verified in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test. In addition, the total phenolics (TPC) and flavonoids contents (TFC) were estimated. In general way, the acetonic and ethanolic extracts showed better results than aqueous extract. At the concentration of 1 mg/mL, both acetonic and ethanolic extracts inhibited the activity of pancreatic lipase by 49.33 and 36.88%, representing 135.26 and 102.75 of inhibited lipase activity per gram of extract (ILA/g). On the other hand, the aqueous extract inhibited lipase by 47.54% at the concentration of 2 mg/mL, which means 213.84 ILA/g. The highest antioxidant activity was observed for the acetonic extract with a 50% effective concentration (EC 50 ) of 7.9 µg/mL, followed by the ethanolic extract with EC 50 of 9.7 µg/mL and the aqueous extract with EC 50 of 12.4 µg/mL. TPC in gallic acid equivalent per gram of sample (GAE/g) were 0.52, 0.51 and 0.35 respectively for the ethanolic, acetonic and aqueous extracts. In turn, TFC in quercetin equivalent per gram of sample (QE/g) were 2.13, 1.89 and 1.35 for the acetonic, ethanolic and aqueous extracts, respectively. Positive and strong correlations (r Pearson > 9.0) between TPC and antioxidant activity were found for all 3 extracts. These results suggest that both pancreatic lipase inhibition and antioxidant activity were distinguished by organic solvents and water extraction. Furthermore, organic extracts (acetone and ethanol) showed to be richer in phenolic metabolites. These metabolites may be related to the biological activities that were found, indicating the stem bark extracts of E. uchi as possible candidates for the development of strategies in the prevention of obesity and hyperlipidemia.

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Peroxidação lipídica e obesidade: Métodos para aferição do estresse oxidativo em obesos

Cited by 32 publications

References 44 publications

Obesity, bariatric surgery and oxidative stress

Obesity, bariatric surgery and oxidative stress

Avaliação da ingestão de nutrientes antioxidantes pela população brasileira e sua relação com o estado nutricional

Stem bark extracts of Endopleura uchi (Huber) Cuatrec: Inhibition of pancreatic lipase and antioxidant activity

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