Peroxidase‐Like Layered Double Hydroxide Nanoflakes for Electrocatalytic Reduction of H₂O₂

Abstract

Peroxidase-like layered double hydroxide (LDH) nanoflakes were synthesized directly and facilely by a one-pot chemical method, hydrothermal treatment. The as-prepared LDHs were characterized by transmission electron microscopy, scanning electron microscopy, X-ray diffraction, Fourier transform IR, and cyclic voltammetry. The functionalized LDHs immobilized on the glassy carbon electrode exhibited a well-defined pair of redox peaks, excellent electrocatalytic activity toward the reduction of hydrogen peroxide without inhibition of dissolved oxygen and a higher affinity for H 2 O 2 , just like the peroxidase. The low apparent Michaelis -Menten constant was only 242 mM. The electrochemical response to H 2 O 2 shows a linear range of 12 -254 mM with the calculated detection limit of 2.3 mM at a signal-to-noise ratio of 3. Furthermore, compared with most metal hexacyanoferrates, the peroxidaselike LDHs are very stable in neutral and alkaline solution. The electrochemical and electrocatalytic behavior of the functionalized LDHs indicate that they may be useful to explore man-made mimics of enzyme in electrochemical biosensors.

Nanostructured Hexacyanoferrate Intercalated Ni/Al Layered Double Hydroxide Modified Electrode as a Sensitive Electrochemical Sensor for Paracetamol Determination

“…The XRD patterns of the Ni−Al LDH and the intercalated compounds exhibit a single crystalline phase with the characteristic reflections of the LDH structure with a series of (003), (006), (009), (015) and (110) peaks. As can be seen, the diffraction peaks of HCF intercalated LDH were shifted to lower 2θ angle with a large basal spacing of 1.046 nm, due to intercalation of hexacyanoferrate, which is in agreement with the results reported for hexacyanoferrate‐containing hydrotalcites . High degree of crystallinity was achieved in the Ni‐Al‐HCF synthesized for 24 h because its XRD pattern shows very strong reflections, indicative of the well crystallized layered structure.…”

“…Intercalation of HCF in Mg−Al, Ni−Fe and Mg−Fe LDHs have been reported previously . Although Tonelli et al.…”

LDHs as Electrode Materials for Electrochemical Detection and Energy Storage: Supercapacitor, Battery and (Bio)-Sensor

“…More recently the same electrocatalyst was used for hydrogen peroxide detection [44]. Similarly, CoTSPc-LDH hybrid material presents electrocatalytic activity toward oxidation of cysteine [45] or dopamine [46], and FeTSPP-LDH is used for the detection of H 2 O 2 [47,48].…”

Nano-Engineered Biomimetic Optical Sensors for Glucose Monitoring in Diabetes

“…In most of the demonstrations metal hydroxides showed peroxidase-like activities [60,61,62,63]. Peroxidase-like activity of CoFe-layered double hydroxides was reported by Sun et al, who further used CoFe hydroxides for colorimetric detection of H 2 O 2 and glucose [64].…”