Peroxidase mimic Cu-MOF nanosheet for highly sensitive colorimetric detection of cysteine

Morphology Control of Self-Assembled Copper Coordination Polymers for Glucose Assays

“…Syntheses using precursor concentrations above or below this concentration range resulted in no material or a material composed of unreacted precursor (Figure S13, Table S3). CuBpyCP PXRD diffractograms show formation of a crystalline material unique from CuCl 2 and 4,4’-Bipyridine precursors and agree with previously described CuBpyCPs. , CuBpyCP formation was also supported by FTIR measurements, where the CuBpyCP FTIR spectra (Figure S12) show a C–N stretching at 1045 cm –1 , and an unsaturated alkene stretching at 3050 cm –1 , confirming the presence of bipyridine in CuBpyCPs. A tensile vibration shift at 1600 cm –1 from the pyridine ring when bound to copper is also observed in CuBpyCPs, compared to the 1560 cm –1 peak in pure bipyridine. , …”

“…One example is copper-based coordination polymers (CuCPs), crystalline materials composed of copper metal centers coordinated to organic ligands. CuCPs exhibit peroxidase-like activity , and show a variety of crystal morphologies and activities that have been tuned for use in analytical applications including cystine sensing, glucose sensing, , and immunoassays. , Many reported CuCPs (Table S1) require extensive synthetic strategies including postsynthetic modifications, extended reaction times, controlled dropwise addition, or synthesis of designer linkers. , CuCPs synthesized in facile aqueous, ambient conditions have been demonstrated but with inferior catalytic activities compared to natural peroxidases ( K m values of >2.47 mM, , HRP K m = 0.44 mM 24 ). We hypothesized that catalytic performance is dependent on CuCP morphology, which can be simply tuned by precursor ratio and concentration, and that morphology control can enable facile synthetic strategies for highly catalytically active and stable CuCPs.…”

“…One example is copper-based coordination polymers (CuCPs), crystalline materials composed of copper metal centers coordinated to organic ligands. CuCPs exhibit peroxidase-like activity 14,15 and show a variety of crystal morphologies and activities that have been tuned for use in analytical applications including cystine sensing, 16 glucose sensing, 17,18 and immunoassays. 19,20 Many reported CuCPs (Table S1) require extensive synthetic strategies including postsynthetic modifications, 19 extended reaction times, 17 controlled dropwise addition, or synthesis of designer linkers.…”