Peroxiredoxin 5 (PRX5) Is Correlated Inversely to Systemic Markers of Inflammation in Acute Stroke

Abstract

Background and Purpose Peroxiredoxins (PRXs) are endogenous antioxidants that function as peroxide and peroxynitrite scavengers. Extracellular PRXs, however, are shown to initiate inflammation within the ischemic brain through activation of Toll-like receptors. Based on this observation, we hypothesized that plasma PRX concentrations in ischemic stroke would correlate biomarkers of inflammation and predict poor outcome. Methods In a prospective study of patients with ischemic stroke, plasma PRX5 concentrations and inflammatory biomarkers at day 3 after stroke onset were correlated and the association between PRX5 at day 3 and outcome at 3 months assessed. Results PRX5 concentrations were available for 98 patients and were lower in those with more severe strokes (P=0.001). PRX5 was inversely correlated to biomarkers of inflammation at day 3 after stroke and did not predict 3 month outcome. Conclusions Plasma PRX5 is decreased in severe stoke and inversely correlated to biomarkers of systemic inflammation. These data suggest that PRX5 is not a pro-inflammatory mediator in acute stroke. Moreover, the inverse relationship between PRX5 and stroke severity suggests that PRX5 is either consumed or its production is impaired in severe stroke. Further study is needed to define the potential role of PRX5 in stroke.

Blood/Brain Biomarkers of Inflammation After Stroke and Their Association With Outcome: From C-Reactive Protein to Damage-Associated Molecular Patterns

“…Moreover, blood Prx1 levels were increased in patients with ischemic stroke compared with healthy controls [95]. In another study [96], circulating Prx5 levels were also measured in 98 patients with acute stroke, being inversely correlated with stroke severity and other inflammatory markers but not associated with outcome [96].…”

Effects of Alcohol on the Cardiovascular System in Women

“…For example, some findings suggest an inverse role between peroxiredoxin 5 and stroke severity. During a severe stroke, peroxiredoxin 5 is consumed and its production impaired ( Kunze et al 2014 ).…”

Danger signals in stroke and their role on microglia activation after ischemia

“… 60 In humans, low plasma levels of Prx-5 but high levels of Prx-1 during the first hours after stroke onset are found. 61 , 62 Treatment with a gastrodin derivative, a constituent from the medicinal plant Gastrodiae rhizoma , reduced the post-ischemic expression of Prx-1, Prx-2 and Prx-4 after middle cerebral artery occlusion (MCAO) and the overall inflammatory response. 63 However, there is also evidence that Prx-2 can have neuroprotective effects in stroke as it inhibits both the poly (ADP-ribose) polymerase 1 (PARP1) and the p53-Bax-mediated death pathway.…”