Peroxiredoxin1 Knockdown Inhibits Oral Carcinogenesis via Inducing Cell Senescence Dependent on Mitophagy

Lu, Yao; Li, Lingyu; Chen, Hui; Jing, Xin; Wang, Min; Ge, Li; Yang, Jing; Zhang, Min; Tang, Xiaofei

doi:10.2147/ott.s284182

Cited by 11 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The second most significant hit was ‘mTOR signaling pathway’, with an adjusted P -value of 1.04 × 10 − 8 , followed by ‘Adherens junction’, and ‘Cellular senenscence’. Importantly, numerous experiments demonstrated these pathways affect the occurrence and development of tongue squamous cell carcinoma ( Coccè et al , 2017 ; Li et al , 2018 , 2019 ; Lorch et al , 2007 ; Lu et al , 2021 ; Yan et al , 2020 ; Yang et al , 2019 ). It is worth mentioning that the addition of differential ncRNAs information can be significantly enriched to more pathways than the results of mRNA list enrichment analysis alone (see Supplementary Tables S2–S4 for details).…”

Section: Resultsmentioning

confidence: 99%

“…In particular, in the joint list enrichment results, these top-ranked additional enriched pathways have been reported to be definitively associated with tongue squamous cell carcinoma compared to mRNA list analysis alone. ( Coccè et al , 2017 ; Li et al , 2018 , 2019 ; Liao et al , 2021 ; Lorch et al , 2007 ; Lu et al , 2021 ; Yan et al , 2020 ; Yang et al , 2019 ). This use case again demonstrates the practical application of NcPath, which allows for comprehensive analysis using pairings of three RNA classes, and helps researchers focusing on potentially more relevant biological findings.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

NcPath: a novel platform for visualization and enrichment analysis of human non-coding RNA and KEGG signaling pathways

Zhang

Fang

et al. 2022

Bioinformatics

View full text Add to dashboard Cite

Summary Noncoding RNAs play important roles in transcriptional processes and participate in the regulation of various biological functions, in particular miRNAs and lncRNAs. Despite their importance for several biological functions, the existing signaling pathway databases do not include information on miRNA and lncRNA. Here, we redesigned a novel pathway database named NcPath by integrating and visualizing a total of 178,308 human experimentally-validated miRNA-target interactions (MTIs), 32,282 experimentally-verified lncRNA target interactions (LTIs), and 4,837 experimentally-validated human ceRNA networks across 222 KEGG pathways (including 27 sub-categories). To expand the application potential of the redesigned NcPath database, we identified 556,798 reliable lncRNA-PCG (protein-coding genes) interaction pairs by integrating co-expression relations, ceRNA relations, co-TF-binding interactions, co-Histone-modification interactions, cis-regulation relations and lncPro Tool predictions between lncRNAs and protein-coding genes. In addition, to determine the pathways in which miRNA/lncRNA targets are involved, we performed a KEGG enrichment analysis using an hypergeometric test. The NcPath database also provides information on MTIs/LTIs/ceRNA networks, PubMed IDs, gene annotations and the experimental verification method used. In summary, the NcPath database will serve as an important and continually updated platform that provides annotation and visualization of the pathways on which noncoding RNAs (miRNA and lncRNA) are involved, and provide support to multimodal noncoding RNAs enrichment analysis. The NcPath database is freely accessible at http://ncpath.pianlab.cn/. Availability and implementation NcPath database is freely available at http://ncpath.pianlab.cn/. The code and manual to use NcPath can be found at https://github.com/Marscolono/NcPath/. Supplementary information Supplementary data are available at Bioinformatics online.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

NcPath: a novel platform for visualization and enrichment analysis of human non-coding RNA and KEGG signaling pathways

Zhang

Fang

et al. 2022

Bioinformatics

View full text Add to dashboard Cite

show abstract

“…The majority of studies conclude that cellular senescence acts primarily as a cancer suppressor rather than a cancer promoter [43][44][45][46][47][48][49][50]. Silencing peroxiredoxin1(Prx1)-induced cellular senescence blocks malignant conversion and inhibits the formation of oral squamous carcinoma [51]. In nasopharyngeal carcinoma, senescent cells promote tumor cell invasion by increasing the secretion of matrix metalloproteinase 9 (MMP 9) [52].…”

Section: Discussionmentioning

confidence: 99%

Identification and verification of aging-related lncRNAs for prognosis prediction and immune microenvironment in patients with head and neck squamous carcinoma

GAO¹,

SHI²,

Sun³

et al. 2023

Oncology Research

View full text Add to dashboard Cite

Aging is highly associated with tumor formation and progression. However, little research has explored the association of aging-related lncRNAs (ARLs) with the prognosis and tumor immune microenvironment (TIME) of head and neck squamous cell carcinoma (HNSCC). RNA sequences and clinicopathological data of HNSCC patients and normal subjects were downloaded from The Cancer Genome Atlas. In the training group, we used Pearson correlation, univariate Cox regression, least absolute shrinkage/selection operator regression analyses, and multivariate Cox regression to build a prognostic model. In the test group, we evaluated the model. Multivariate Cox regression was done to screen out independent prognostic factors, with which we constructed a nomogram. Afterward, we demonstrated the predictive value of the risk scores based on the model and the nomogram using time-dependent receiver operating characteristics. Gene set enrichment analysis, immune correlation analysis, and half-maximal inhibitory concentration were also performed to reveal the different landscapes of TIME between risk groups and to predict immuno-and chemo-therapeutic responses. The most important LINC00861 in the model was examined in HNE1, CNE1, and CNE2 nasopharyngeal carcinoma cell lines and transfected into the cell lines CNE1 and CNE2 using the LINC00861-pcDNA3.1 construct plasmid. In addition, CCK-8, Edu, and SA-β-gal staining assays were conducted to test the biofunction of LINC00861 in the CNE1 and CNE2 cells. The signature based on nine ARLs has a good predictive value in survival time, immune infiltration, immune checkpoint expression, and sensitivity to multiple drugs. LINC00861 expression in CNE2 was significantly lower than in the HNE1 and CNE1 cells, and LINC00861 overexpression significantly inhibited the proliferation and increased the senescence of nasopharyngeal carcinoma cell lines. This work built and verified a new prognostic model for HNSCC based on ARLs and mapped the immune landscape in HNSCC. LINC00861 is a protective factor for the development of HNSCC.

show abstract

“… 299 In addition, senescent CAFs facilitate the rapid progression of oral malignancies in genetically unstable OSCC by promoting keratinocyte migration, inhibiting epithelial adhesions, and releasing active matrix metalloproteinases-2 (MMP-2). 300 – 303 CXCL1 304 and peroxiredoxin1 (PRDX1) 305 drive the development of OSCC through the induction of cell senescence.…”

Section: Dysregulated Tumor Microenvironment In Osccmentioning

confidence: 99%

Oral squamous cell carcinomas: state of the field and emerging directions

Tan,

Wang,

et al. 2023

Int J Oral Sci

140

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) develops on the mucosal epithelium of the oral cavity. It accounts for approximately 90% of oral malignancies and impairs appearance, pronunciation, swallowing, and flavor perception. In 2020, 377,713 OSCC cases were reported globally. According to the Global Cancer Observatory (GCO), the incidence of OSCC will rise by approximately 40% by 2040, accompanied by a growth in mortality. Persistent exposure to various risk factors, including tobacco, alcohol, betel quid (BQ), and human papillomavirus (HPV), will lead to the development of oral potentially malignant disorders (OPMDs), which are oral mucosal lesions with an increased risk of developing into OSCC. Complex and multifactorial, the oncogenesis process involves genetic alteration, epigenetic modification, and a dysregulated tumor microenvironment. Although various therapeutic interventions, such as chemotherapy, radiation, immunotherapy, and nanomedicine, have been proposed to prevent or treat OSCC and OPMDs, understanding the mechanism of malignancies will facilitate the identification of therapeutic and prognostic factors, thereby improving the efficacy of treatment for OSCC patients. This review summarizes the mechanisms involved in OSCC. Moreover, the current therapeutic interventions and prognostic methods for OSCC and OPMDs are discussed to facilitate comprehension and provide several prospective outlooks for the fields.

show abstract

Peroxiredoxin1 Knockdown Inhibits Oral Carcinogenesis via Inducing Cell Senescence Dependent on Mitophagy

Cited by 11 publications

References 50 publications

NcPath: a novel platform for visualization and enrichment analysis of human non-coding RNA and KEGG signaling pathways

NcPath: a novel platform for visualization and enrichment analysis of human non-coding RNA and KEGG signaling pathways

Identification and verification of aging-related lncRNAs for prognosis prediction and immune microenvironment in patients with head and neck squamous carcinoma

Oral squamous cell carcinomas: state of the field and emerging directions

Contact Info

Product

Resources

About