Peroxiredoxins in erythrocytes: far beyond the antioxidant role

de Paula, Carla Peres; de Oliveira da Silva, João Pedro Maia; Romanello, Karen Simone; Bernardo, Victoria Simões; Torres, Flaviene Felix; da Silva, Danilo Grünig Humberto; da Cunha, Anderson Ferreira

doi:10.1007/s00109-023-02368-7

Cited by 4 publications

(2 citation statements)

References 147 publications

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“…It is reported that oxidative stress plays an important role in the pathogenesis of DKD. Wherein, PRDX family members are believed to play an important role in the process of oxidative stress 37 . Transcriptomic analysis of kidney tissue from DKD patients revealed that PRDX family members were not signi cantly upregulated or downregulated at the transcriptional level (Gene Expression Omnibus, GSE142025) 26 ; nevertheless, proteomic analysis of urine from DKD patients found that only PRDX1, 2, and 5 could be detected in urine, with the highest abundance of PRDX2, which was 2.6 times higher than that of DM patients (ProteomeXchange Datasets, PXD016571) 27 .…”

Section: Discussionmentioning

confidence: 99%

“…The role of the PRDX family members is diverse, and in addition to antioxidant activity, they can also function as a molecular chaperone, transduce peroxide signal, protect membranes from damage, and play a role in maintaining iron homeostasis 37 . A recent study found that PRDX2 participated in the cellular response to ROS and activated downstream signaling pathways through excessive oxidation by ROS within the cell.…”

Section: Discussionmentioning

confidence: 99%

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A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages

Li,

Long,

Peng

et al. 2024

Preprint

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Diabetic kidney disease (DKD) is the main cause of death due to diabetes mellitus (DM). Due to the complexity of the onset, it is difficult to achieve accurate prevention and treatment. The classically activated macrophages (M1) polarization is a crucial proinflammatory mechanism in DKD, while the interaction and cascade effects of oxidative stress and inflammatory response remain to be elucidated. A urine proteomic analysis of DM patients indicated that peroxiredoxin 2 (PRDX2) had the higher abundance in DKD. We recently found that PRDX of parasitic protozoa Entamoeba histolytica, which was similar to human PRDX2 in amino acid sequence and spatial structure, could activate the inflammatory response of macrophages through toll like receptor 4 (TLR4). Hence, our study was designed to explore the role of PRDX2 in chronic inflammation during DKD. Combined with in vivo and in vitro experiments, results showed that the PRDX2 was positively correlated with DKD progression and upregulated by high glucose or recombinant tumor necrosis factor-α in renal tubular epithelial cells; Besides, recombinant PRDX2 could promote macrophages M1 polarization, enhance the migration and phagocytic ability of macrophages through TLR4. In summary, our study has explored the novel role of PRDX2 in DKD to provide basis for further researches on the diagnosis and treatment of DKD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages

Li,

Long,

Peng

et al. 2024

Preprint

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Electrochemical Probing of Dopamine Dynamics During Poly(I:C)‐Induced Neuroinflammation

Wang,

Zhou,

Zhang

et al. 2024

Small

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Viruses can infiltrate the central nervous system and contribute to depression, which may include alterations in dopamine (DA) metabolism triggered by immune responses though the specific mechanisms involved remain unclear. Here, an electrochemical system to realize the real‐time dynamic monitoring of DA with high sensitivity is proposed and it is demonstrated that the viral simulator polyinosinic‐polycytidylic acid (poly(I:C)) can inhibit the release of DA (from 5.595 to 0.137 µm) in neurons from the perspective of single cells, cell populations and even in vivo through the combination of multiscale electrodes, including single nanowires, carbon fibers (CFs) and 2D flexible electrodes. These findings are associated with the increase in reactive oxygen species (ROS) produced by microglia. At the molecular level, poly(I:C) significantly decreases the expression of α‐synuclein and increases its phosphorylation level, whereas ROS inhibitors can reverse these pathological changes and salvage DA release to half the initial level (≈2.6 µM). These results suggest that viruses may indirectly inhibit DA system function through ROS produced in inflammatory responses and that antioxidant activity may be a potential therapeutic strategy.

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Influence of inhibiting methemoglobin formation on erythrocyte antioxidant defense

Melo,

Coimbra,

Rocha

et al. 2024

Archives of Biochemistry and Biophysics

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Peroxiredoxins in erythrocytes: far beyond the antioxidant role

Cited by 4 publications

References 147 publications

A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages

A novel role of peroxiredoxin 2 in diabetic kidney disease progression by activating the classically activated macrophages

Electrochemical Probing of Dopamine Dynamics During Poly(I:C)‐Induced Neuroinflammation

Influence of inhibiting methemoglobin formation on erythrocyte antioxidant defense

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