Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid

Jenkins, Benjamin; Schryver, Evelyn de; Veldhoven, Paul P. Van; Koulman, Albert

doi:10.3390/molecules22101718

Cited by 21 publications

(19 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data support that circulating OCFA levels can be effectively raised proportionally by the amount of dietary OCFAs ingested. Similar findings have been reported for C15:0 in humans; in contrast, C17:0 blood levels in humans do appear to be higher than expected given dietary C17:0, supporting endogenous production of C17:0 [6,[21][22].…”

Section: Plos Onesupporting

confidence: 84%

Modified fish diet shifted serum metabolome and alleviated chronic anemia in bottlenose dolphins (Tursiops truncatus): Potential role of odd-chain saturated fatty acids

et al. 2020

View full text Add to dashboard Cite

Bottlenose dolphins (Tursiops truncatus) are long-lived mammals that can develop chronic aging-associated conditions similar to humans, including metabolic syndrome. Initial studies suggest that these conditions may be attenuated in dolphins using a modified fish diet. Serum metabolomics, fatty acid panels, and blood-based health indices were compared between 20 dolphins on a modified, 50% wild-type diet (50% mullet, 25% capelin, and 25% squid and/or herring) and 10 dolphins on a baseline diet (75% capelin and 25% squid and/or herring). Blood samples were collected at Months 0, 1, 3 and 6. Dolphins on the modified diet had lower insulin (7.5 ± 4.0 and 14.8 ± 14.0 μIU/ml, P = 0.039), lower cholesterol (160 ± 26 and 186 ± 24 mg/dl, P = 0.015) and higher hematocrit (46 ± 3 and 44 ± 3%, P = 0.043) by Month 1 compared to controls. Dolphins with anemia (hemoglobin � 12.5 g/dl, n = 6) or lownormal hemoglobin (12.5-13.5 g/dl, n = 3) before placed on the modified diet had normal hemoglobin concentrations (> 13.5 g/dl) by Month 3. The modified diet caused a significant shift in the metabolome, which included 664 known metabolites. Thirty prioritized metabolites at Months 1 and 3 were 100% predictive of dolphins on the modified diet. Among 25 prioritized lipids, 10 (40%) contained odd-chain saturated fatty acids (OCFAs); C15:0 was the highest-prioritized OCFA. Increased dietary intake of C15:0 (from 1.3 ± 0.4 to 4.5 ± 1.1 g/ day) resulted in increased erythrocyte C15:0 concentrations (from 1.5 ± 0.3 to 5.8 ± 0.8 μg/ ml, P < 0.0001), which independently predicted raised hemoglobin. Further, increasing age was associated with declining serum C15:0 (R 2 = 0.14, P = 0.04). While higher circulating OCFAs have been previously associated with lower risks of cardiometabolic diseases in humans, further studies are warranted to assess potential active roles of OCFAs, including C15:0, in attenuating anemia.

show abstract

Section: Plos Onesupporting

confidence: 84%

Modified fish diet shifted serum metabolome and alleviated chronic anemia in bottlenose dolphins (Tursiops truncatus): Potential role of odd-chain saturated fatty acids

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In the literature it is shown that C15:0 and C17:0 may originate from different sources; C15:0 comes directly from the diet, while C17:0 is also significantly endogenously biosynthesized [2,7]. The results presented here support a dietary origin for C15:0, since the in vivo C15:0 compositions decrease with an increase in dietary total-fat.…”

Section: Discussionsupporting

confidence: 68%

“…In contrast, there is convincing evidence showing that C17:0 does not directly relate to dietary intake. Instead, C17:0 endogenous biosynthesis has a significant influence on its circulating levels [2,7]. Furthermore, the literature suggests that C17:0 may have a significant pathophysiological relevance and could be subject to in vivo homeostasis.…”

Section: Introductionmentioning

confidence: 99%

The Dietary Total-Fat Content Affects the <em>In Vivo</em> Circulating C15:0 and C17:0 Fatty Acid Concentrations Independently to the Dietary Fatty Acid Compositions; Highlighting Dietary Routes that may Attenuate the Development of Metabolic Disease

Jenkins¹,

Aoun²,

Feillet‐Coudray³

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

Pentadecanoic acid (C15:0) and heptadecanoic acid (C17:0) have been described as dietary biomarkers of dairy-fat consumption with varying degrees of reliability between studies. It remains unclear how the total amount of dietary fat; one of the main confounding factors in these biomarker investigations, affects C15:0 and C17:0 circulating compositions independently to their relative intake. Additionally, it is unknown how changes in the dietary total-fat affects other fatty acids in circulation. Through two dietary studies with different total-fat levels but maintaining individual fatty acid compositions we were able to see how the dietary total-fat affects the fatty acids in circulation. We saw that there was a significant, proportionate, and robust decrease in the endogenous C15:0 levels with an increase in dietary total-fat. However, there was an increase in the circulating C17:0 compositions as the total-fat increased. To conclude, the dietary total-fat content and fat-type have a very complex influence on the relative compositions of circulating fatty acids, which are independent to the actual dietary fatty acid composition. Knowing how to manipulate circulating C15:0 and C17:0 composition is far-reaching in nutritional/pathological research as they highlight a dietary route to attenuate the development of metabolic disease (both by reducing risk and improving prognosis).

show abstract

“…Finally after activation to its CoA-ester, pristanoyl-CoA undergoes three cycles of β-oxidation in peroxisomes prior to transport of end products to mitochondria for complete oxidation (36) . Both propionyl CoA and pristanal produced in peroxisomes by phytanoyl-CoA 2-hydroxy lyase activity are important precursors for biosynthesis of OCFA (39) (Fig. 2).…”

Section: Peroxisomes In Fatty Acid α-And β-Oxidationmentioning

confidence: 99%

Dietary protein insufficiency: an important consideration in fatty liver disease?

et al. 2019

View full text Add to dashboard Cite

Dietary protein insufficiency has been linked to excessive TAG storage and non-alcoholic fatty liver disease (NAFLD) in developing countries. Hepatic TAG accumulation following a low-protein diet may be due to altered peroxisomal, mitochondrial and gut microbiota function. Hepatic peroxisomes and mitochondria normally mediate metabolism of nutrients to provide energy and substrates for lipogenesis. Peroxisome biogenesis and activities can be modulated by odd-chain fatty acids (OCFA) and SCFA that are derived from gut bacteria, for example, propionate and butyrate. Also produced during amino acid metabolism by peroxisomes and mitochondria, propionate and butyrate concentrations correlate inversely with risk of obesity, insulin resistance and NAFLD. In this horizon-scanning review, we have compiled available evidence on the effects of protein malnutrition on OCFA production, arising from loss in mitochondrial, peroxisomal and gut microbiota function, and its association with lipid accumulation in the liver. The methyl donor amino acid composition of dietary protein is an important contributor to liver function and lipid storage; the presence and abundance of dietary branched-chain amino acids can modulate the composition and metabolic activity of the gut microbiome and, on the other hand, can affect protective OCFA and SCFA production in the liver. In preclinical animal models fed with low-protein diets, specific amino acid supplementation can ameliorate fatty liver disease. The association between low dietary protein intake and fatty liver disease is underexplored and merits further investigation, particularly in vulnerable groups with dietary protein restriction in developing countries.

show abstract

Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid

Cited by 21 publications

References 21 publications

Modified fish diet shifted serum metabolome and alleviated chronic anemia in bottlenose dolphins (Tursiops truncatus): Potential role of odd-chain saturated fatty acids

Modified fish diet shifted serum metabolome and alleviated chronic anemia in bottlenose dolphins (Tursiops truncatus): Potential role of odd-chain saturated fatty acids

The Dietary Total-Fat Content Affects the <em>In Vivo</em> Circulating C15:0 and C17:0 Fatty Acid Concentrations Independently to the Dietary Fatty Acid Compositions; Highlighting Dietary Routes that may Attenuate the Development of Metabolic Disease

Dietary protein insufficiency: an important consideration in fatty liver disease?

Contact Info

Product

Resources

About