2013
DOI: 10.11648/j.ab.20130101.12
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Peroxisomal Heat Generation and Possible Relationship With Peroxisomal Disorders

Abstract: Abstract:Peroxisomal disorders encompass a variety of pathologies with different clinical manifestations. X-linked adrenoleukodystrophy, an inherited neurodegenerative pathology, is characterized by mutation of a peroxisomal transport protein involved in the catabolism of very long-chain fatty acids (VLCFAs). These particular fatty acids abnormally accumulate in plasma and in all tissues due to the enhancement of fatty acid elongation and the impairment of fatty acid catabolism which takes place initially in t… Show more

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Cited by 2 publications
(2 citation statements)
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“…Heat is generated in a variety of cellular metabolic pathways, although the energy reserve is rarely considered in biological studies, even though it could modulate different parameters. The heat produced by peroxisomes is considered lost (Petroni, 2013;Schulz, 1996), whereas it could have a role in X-ALD pathogenesis.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Heat is generated in a variety of cellular metabolic pathways, although the energy reserve is rarely considered in biological studies, even though it could modulate different parameters. The heat produced by peroxisomes is considered lost (Petroni, 2013;Schulz, 1996), whereas it could have a role in X-ALD pathogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…During metabolic processes, peroxisomes do not produce ATP but develop heat, which is considered to be dispersed in the cell (Schulz, 1996). Heat is a form of energy that could be useful for cellular maintenance and it might have a role in the pathogenesis of peroxisomal disorders (Petroni, 2013).…”
Section: Introductionmentioning
confidence: 99%