Peroxisome Biogenesis in Rat Liver During Adaptation to Mild Hyperthyroidism: A Morphometric/Stereologic Study by Electron Microscopy

Fringes, Birgitta; Reith, Albrecht; Riede, U. N.

doi:10.1111/j.1749-6632.1982.tb21467.x

Cited by 19 publications

(13 citation statements)

References 7 publications

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“…it was reported that thyroxine treatment for five consecutive days resulted in a 2.4-fold rise of 3,3'-diaminobenzidine-stainable profiles in isolated hepatocytes. A detailed stereologic study on the influence of 20 jug triiodothyronine/100 g body weight per day on hepatic organelle alteration was reported recently I 23 1. This dose of triiodothyronine is supposed to raise a more pronounced hyperthyreosis than the thyroxine dose used in this study.…”

Section: Discussionmentioning

confidence: 99%

Rat Liver Peroxisomes, II. Stimulation of Peroxisomal Fatty-Acid β-Oxidation by Thyroid Hormones

Just¹,

Hartl²

1983

Hoppe-Seyler´s Zeitschrift für physiologische Chemie

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From liver homogenates of control comparable with each other. A 2.5-fold increase and thyroxine-treated rats the light mitochonin peroxisomal palmitoyl-CoA oxidation raising drial fractions were prepared by differential the activity from 0.089 to 0.220 U/g as esticentrifugation. Mitochondria and peroxisomes of mated in the light mitochondrial fractions was these fractions were further separated by isofound following treatment of male rats with pycnic sucrose density gradient centrifugation.dayly doses of 25 % L-thyroxine (s.c.) over a periAnalysis of the activities of the peroxisomal od of 10 days. Total hepatic peroxisomal fattymarker enzymes catalase and urate oxidase acyl-CoA oxidation was calculated based on throughout the gradient exhibited completely estimations in the light mitochondrial fractions, corresponding distributions with that of peroxi-The difficulties encountered herein are discussed, somal palmitoyl-CoA oxidation. Thyroxine T h e present result replenishes the broad spectrum treatment did not change the proportion of o f cellular effects exerted by thyroid hormones mitochondria and peroxisomes present in the and indicates that both the mitochondrial and the differential fractions of the homogenate. Conseperoxisomal system contribute to the well known quently, the activities of peroxisomal 0-oxidahormone effects such as increase in fatty-acid tion in the light mitochondrial fractions of conoxidation, 0 2 consumption and heat productrol and thyroxine-treated animals were directly Rattenleberperoxisomen, II. Stimulierung der peroxisomalen Fettsäure-ß-Oxidation durch Schilddrüsenhormone

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Section: Discussionmentioning

confidence: 99%

Rat Liver Peroxisomes, II. Stimulation of Peroxisomal Fatty-Acid β-Oxidation by Thyroid Hormones

Just¹,

Hartl²

1983

Hoppe-Seyler´s Zeitschrift für physiologische Chemie

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“…In adult rat liv-er these membrane extensions can be induced in the regenerating phase after partial hepatectomy (Novikoff and Shin 1964), in hyperthyroid rats (Fringes and Reith 1982), or after treatment with most peroxisome proliferators, when the peroxisomal compartment is rapidly expanding (Hruban et al 1966(Hruban et al , 1974Svoboda and Azarnoff 1966;Svoboda et al 1967;Reddy and Svoboda 1973;Baumgart et al 1987;Yokota 1990). The observation of catalase-negative tail-like extensions on the peroxisomal surface and the close association of peroxisomes with the smooth endoplasmic reticulum led Novikoff and Shin (1964) to suggest that peroxisomes were formed by budding from specialized regions of the endoplasmic reticulum.…”

Section: Figmentioning

confidence: 99%

Application of in situ hybridization, cytochemical and immunocytochemical techniques for the investigation of peroxisomes

Baumgart

1997

Histochemistry and Cell Biology

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In situ hybridization, cytochemical and immunocytochemical techniques have contributed significantly to the understanding of the biology of peroxisomes, since they permit in situ demonstration of the sites of synthesis and distribution of peroxisomal proteins without the necessity of homogenization and subcellular fractionation of tissues or cultured cells. This article reviews the results of research on mammalian peroxisomal metabolism, biogenesis and proliferation in which morphological techniques have played a significant role in the elucidation of the biological problem. Some new data on peroxisomal heterogeneity and morphogenesis are included. The morphological methods applied have made it possible to characterize the differences in distribution of mRNAs encoding peroxisomal proteins in different tissues, as well as to monitor the marked heterogeneity in the protein composition and in the activity of specific enzymes in the peroxisomal population of single cells, or in tissues with complex organization (e.g. liver and kidney). In addition, the dynamic alterations and high plasticity of the peroxisomal compartment--partly dependent on contact of the peroxisomes to the microtubular network-are presented.

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“…Among these conditions and factors are diabetes (31,32), changes in thyroid hormone levels (33,34), cold adaptation (17), endotoxin exposure (35), high-fat diets (36), and partial hepatectomy (37 Figure 1) (42). These chemicals promote differentiation of preadipocytes and act as an insulin-sensitizing agent (43).…”

Section: Peroxisomes: Function and Proliferationmentioning

confidence: 99%

Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.

Youssef

Badr

1999

Environ Health Perspect

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Despite rising interest in the health problems of the elderly, information on senescence-related alterations in essential metabolic pathways and their responses to various chemicals is scarce. Although peroxisomal pathways are involved in a multitude of cellular fnctions, little attention has been given to the potential relationship between senescence of these organelles and the process of aging and disease. Although the prevailing experimental evidence points to a decline in liver peroxisomal enzyme activities and a muted response to peroxisome-proleratn chemicals in aged animals, it is also evident that aged animals are more susceptible, inl comparison to their young counterparts, to the hepatocarcinogenic efecs of these chemicals. Furthermore, little is known about extraperoxisomal effects of peroxisome proliferators in aged animals. This review evaluates published studies on the impat of aging on basal hepatic:peroxisomal metabolism, response to peroxisome proliferators, and changes in signal trauction pathways involved in these processes, with the aim of stimulating research efforts in this important area. The potential intricate relationship among senescent perosomes, aged hepatocytes, and health are also discussed.

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Peroxisome Biogenesis in Rat Liver During Adaptation to Mild Hyperthyroidism: A Morphometric/Stereologic Study by Electron Microscopy

Cited by 19 publications

References 7 publications

Rat Liver Peroxisomes, II. Stimulation of Peroxisomal Fatty-Acid β-Oxidation by Thyroid Hormones

Rat Liver Peroxisomes, II. Stimulation of Peroxisomal Fatty-Acid β-Oxidation by Thyroid Hormones

Application of in situ hybridization, cytochemical and immunocytochemical techniques for the investigation of peroxisomes

Biology of senescent liver peroxisomes: role in hepatocellular aging and disease.

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