Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition

Froment, Pascal; Gizard, Florence; Defever, D; Staels, Bart; Dupont, Joëlle; Monget, Philippe

doi:10.1677/joe.1.06667

Cited by 182 publications

(150 citation statements)

References 101 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…It is expressed in adipose tissue, macrophages, intestines, ovaries and plays a crucial role in the regulation of energy storage, insulin sensitivity, adipocyte differentiation and lipid metabolism [10]. PPAR-γ was demonstrated to be up-regulated in the ovaries of PCOS patients [11], which was consistent with other animal studies [12][13][14]. Recently, many researchers focused on the association between Pro12Ala polymorphism (rs1801282) in PPAR-γ and PCOS, which may facilitate to elucidate the pathogenesis of this condition.…”

Section: Introductionsupporting

confidence: 86%

A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome

Wang

Liu

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose To investigate the influence of the peroxisome proliferator activated receptor gamma (PPAR-γ) Pro12Ala polymorphism on the susceptibility of polycystic ovary syndrome (PCOS) and body mass index (BMI), fast insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR) in PCOS patients. Methods PubMed, EMBASE, MEDLINE and CENTRAL databases were searched to identify eligible studies. We then conducted a meta-analysis to examine the association between Pro12Ala polymorphism and PCOS. Results Seventeen eligible studies, including 2,149 patients and 2,124 controls were enrolled in this meta-analysis. Conclusions Ala variant would decrease the risk of PCOS and result in lower BMI and fast insulin levels in a European population, but had no impact on HOMA-IR in PCOS patients. Further studies are required to elucidate these associations more clear.

show abstract

Section: Introductionsupporting

confidence: 86%

A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome

Wang

Liu

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…These results suggest that PPARb is expressed in the epithelium and stroma of normal ovaries, benign, borderline and low-to high-grade ovarian tumours, but compared to benign and borderline tumours, there is a declining pattern of expression in high-grade ovarian tumours. The expression of PPARb has been demonstrated previously in the theca and stromal component of normal ovaries (Froment et al, 2006). Considering that the expression and activation of PPARb is usually triggered by inflammation and that normal ovaries undergo inflammation-mediated responses even immediately after menopause (due to high levels of gonadotrophins), the persistent expression of PPARb in the epithelial and stromal component of normal ovaries of the control group used in the study is not surprising.…”

Section: Extent Of Staining In the Epitheliumsupporting

confidence: 66%

An immunohistochemical perspective of PPARβ and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours

2008

View full text Add to dashboard Cite

Peroxisome proliferator-activated receptor b (PPARb) is a member of the nuclear hormone receptor family and is a ligand-activated transcription factor with few known molecular targets including 3-phosphoinositide-dependent protein kinase 1(PDK1). In view of the association of PPARb and PDK1 with cancer, we have examined the expression of PPARb and PDK1 in normal ovaries and different histological grades of ovarian tumours. Normal ovaries, benign, borderline, grades 1, 2 and 3 ovarian tumours of serous, muciuous, endometrioid, clear cell and mixed subtypes were analysed by immunohistochemistry for PPARb and PDK1 expression. All normal ovarian tissues, benign, borderline and grade 1 tumours showed PPARb staining localised in the epithelium and stroma. Staining was predominantly nuclear, but some degree of cytoplasmic staining was also evident. Approximately 20% of grades 2 and 3 tumours lacked PPARb staining, whereas the rest displayed some degree of nuclear and cytoplasmic staining of the scattered epithelium and stroma. In contrast, PDK1 immunostaining was absent in 9 out of 10 normal ovaries. Weak staining for PDK1 was observed in one normal ovary and 40% of benign ovarian tumours. All borderline and malignant ovarian tumours showed positive cytoplasmic and membrane PDK1 staining. Staining of PDK1 was confined to the epithelium and the blood vessels, and no apparent staining of the stroma was evident. Significantly different PDK1 staining was observed between the benign/borderline and malignant ovarian tumours (w 2 ¼ 22.45, d.f. ¼ 5, Po0.001). In some borderline and high-grade tumours, staining of the reactive stroma was also evident. Our results suggest that unlike the colon, the endometrial, head and neck carcinomas, overexpression of PPARb does not occur in ovarian tumours. However, overexpression of PDK1 was evident in borderline and low-to high-grade ovarian tumours and is consistent with its known role in tumorigenesis.

show abstract

“…It has been demonstrated that PPARg modulates follicular development, oocyte maturation, ovulation and the CL formation or regression [22,28]. These effects are mediated by the regulation of several genes controlling angiogenesis, inflammatory response, apoptosis and cell cycle.…”

Section: Ppars and Remodeling Of The Ovarian Tissuementioning

confidence: 99%

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Bogacka

Kurzyńska

Bogacki

et al. 2015

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

Peroxisome proliferator-activated receptors (PPARs) belong to a ligand-dependent nuclear receptor family. In the past decade, numerous studies have revealed the presence and significance of PPARs in the reproductive system. PPARs are expressed at different levels of hypothalamic-pituitary-gonadal (HPG) axis. They are also present in the uterus as well as in the placenta and embryonic tissues of different species. PPARs significance has been reported during the estrous/menstrual cycle and pregnancy with the gamma isoform studied most frequently. Several studies indicate that PPARs regulate proliferation of ovarian cells, tissue remodeling and steroidogenesis. In the endometrium, PPARs are engaged in the regulation of prostaglandins, steroids and cytokines synthesis. The role of PPARs in the trophoblast differentiation, maturation and invasion as well as in the embryo development has also been demonstrated. In this review, we summarize current findings concerning the role of PPARs in the regulation of reproductive functions at different levels of the HPG axis during various physiological statuses of females. In addition, the role of PPARs in the modulation of uterine functions as well as the placenta and embryo development has also been discussed.

show abstract

Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition

Abstract: Peroxisome proliferator-activated receptors

Cited by 182 publications

References 101 publications

A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome

A meta-analysis on the association between PPAR-γ Pro12Ala polymorphism and polycystic ovary syndrome

An immunohistochemical perspective of PPARβ and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours

Peroxisome proliferator-activated receptors in the regulation of female reproductive functions

Contact Info

Product

Resources

About