2023
DOI: 10.1002/jgm.3605
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Peroxisome proliferator‐activated receptors signature reveal the head and neck squamous cell carcinoma energy metabolism phenotype and clinical outcome

Yuan Yao,
Di Wang,
Yu Zhang
et al.

Abstract: BackgroundPeroxisome proliferator activating receptors (PPARs) are important regulators of nuclear hormone receptor function, and they play a key role in biological processes such as lipid metabolism, inflammation and cell proliferation. However, their role in head and neck squamous cell carcinoma (HNSC) is unclear.MethodsWe used multiple datasets, including TCGA‐HNSC, GSE41613, GSE139324, PRJEB23709 and IMVigor, to perform a comprehensive analysis of PPAR‐related genes in HNSC. Single‐cell sequencing data wer… Show more

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