Peroxisomes: minted by the ER

Tabak, Henk F.; Zand, Adabella van der; Braakman, Ineke

doi:10.1016/j.ceb.2008.05.008

Cited by 53 publications

(45 citation statements)

References 42 publications

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“…Yet other mPPs, such as POX1 and GPD1, also colocalized to some degree with the ER (Table S3). The association of mPP with the ER could result from direct targeting (i.e., as in the case of PEX3 mRNA) or indirectly due to the known ER-peroxisome connection (19). While our own observations indicate that peroxisomes are tightly juxtaposed with either cortical or nuclear ER (Fig.…”

Section: Discussionmentioning

confidence: 41%

“…S1E). Cells lacking PEX3 are devoid of peroxisomes (19), and the expression of RFP-PTS1 led to cytosolic staining, as expected. Although fluorescent RNA granules were observed in these cells, they showed no specific pattern of localization.…”

Section: Pex14 Mrna Associates With Peroxisomes Throughout the Cell Cmentioning

confidence: 66%

“…Importantly, mRNAs known to localize with cortical ER (i.e., CDC42 and SEC4) (7) were not observed in the peroxisome fraction, although SEC61 mRNA was. This may represent nuclear ER contamination; studies have shown that peroxisomes are derived from ER (19). Moreover, we noted a close link between the ER and peroxisomes (Fig.…”

Section: Subcellular Fractionation Of Peroxisomes and The Detection Omentioning

confidence: 72%

“…importation of proteins via membrane-bound polysomes. A second set, comprising PEX3 mRNA, associates with ER and is consistent with the fact that Pex3 translocates to the ER (19). Finally, a third set of mRNAs does not localize to peroxisomes.…”

mentioning

confidence: 71%

“…2C). PEX3 mRNA localization to ER membranes likely guarantees Pex3 access to the secretory pathway, which is necessary for peroxisome biogenesis de novo (19,29). Yet other mPPs, such as POX1 and GPD1, also colocalized to some degree with the ER (Table S3).…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Localization of mRNAs coding for peroxisomal proteins in the yeast, Saccharomyces cerevisiae

Zipor

Haim-Vilmovsky

Gelin-Licht

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 41%

Section: Pex14 Mrna Associates With Peroxisomes Throughout the Cell Cmentioning

confidence: 66%

Section: Subcellular Fractionation Of Peroxisomes and The Detection Omentioning

confidence: 72%

mentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Localization of mRNAs coding for peroxisomal proteins in the yeast, Saccharomyces cerevisiae

Zipor

Haim-Vilmovsky

Gelin-Licht

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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Oxygen radicals shaping evolution: Why fatty acid catabolism leads to peroxisomes while neurons do without it

2010

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Oxygen radical formation in mitochondria is a highly important, but incompletely understood, attribute of eukaryotic cells. I propose a kinetic model in which the ratio between electrons entering the respiratory chain via FADH₂ or NADH is a major determinant in radical formation. During the breakdown of glucose, this ratio is low; during fatty acid breakdown, this ratio is much higher. The longer the fatty acid, the higher the ratio and the higher the level of radical formation. This means that very long chain fatty acids should be broken down without generation of FADH₂ for mitochondria. This is accomplished in peroxisomes, thus explaining their role and evolution. The model explains many recent observations regarding radical formation by the respiratory chain. It also sheds light on the reasons for the lack of neuronal fatty acid (beta-) oxidation and for beneficial aspects of unsaturated fatty acids. Last but not least, it has very important implications for all models describing eukaryotic origins.

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Evolution of peroxisomes illustrates symbiogenesis

Speijer

2017

BioEssays

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Recently, the group of McBride reported a stunning observation regarding peroxisome biogenesis: newly born peroxisomes are hybrids of mitochondrial and ER-derived pre-peroxisomes. What was stunning? Studies performed with the yeast Saccharomyces cerevisiae had convincingly shown that peroxisomes are ER-derived, without indications for mitochondrial involvement. However, the recent finding using fibroblasts dovetails nicely with a mechanism inferred to be driving the eukaryotic invention of peroxisomes: reduction of mitochondrial reactive oxygen species (ROS) generation associated with fatty acid (FA) oxidation. This not only explains the mitochondrial involvement, but also its apparent absence in yeast. The latest results allow a reconstruction of the evolution of the yeast's highly derived metabolism and its limitations as a model organism in this instance. As I review here, peroxisomes are eukaryotic inventions reflecting mutual host endosymbiont adaptations: this is predicted by symbiogenetic theory, which states that the defining eukaryotic characteristics evolved as a result of mutual adaptations of two merging prokaryotes.See also the video abstract here: https://youtu.be/ HtyKhQ3DSxg

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Peroxisomes: minted by the ER

Cited by 53 publications

References 42 publications

Localization of mRNAs coding for peroxisomal proteins in the yeast, Saccharomyces cerevisiae

Localization of mRNAs coding for peroxisomal proteins in the yeast, Saccharomyces cerevisiae

Oxygen radicals shaping evolution: Why fatty acid catabolism leads to peroxisomes while neurons do without it

Evolution of peroxisomes illustrates symbiogenesis

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