Peroxynitrite and myeloperoxidase leave the same footprint in protein nitration

Kettle, Anthony J.; Dalen, Christine J. van; Winterbourn, Christine C.

doi:10.1080/13510002.1997.11747120

Cited by 91 publications

(62 citation statements)

References 15 publications

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“…Spatial mapping showed that myeloperoxidase immunoreactivity strongly colocalized with nitrotyrosine formation (Baldus et al, 2002). Peroxynitrite and myeloperoxidase 'leave the same footprint in protein nitration' (Kettle et al, 1997). Kinetic arguments show that this is much more likely to involve NO 2 generated from NO 2 À by myeloperoxidase than reaction with HOCl (Kettle et al, 1997).…”

Section: Oxidation and Nitration Initiated By Superoxide ( O 2 à ) Anmentioning

confidence: 99%

“…Peroxynitrite and myeloperoxidase 'leave the same footprint in protein nitration' (Kettle et al, 1997). Kinetic arguments show that this is much more likely to involve NO 2 generated from NO 2 À by myeloperoxidase than reaction with HOCl (Kettle et al, 1997). Figure 1 is not exhaustive in its mapping of reaction pathways: radical-radical reactions are often facile, and several of relevance have been characterized (Ross et al, 1998).…”

Section: Oxidation and Nitration Initiated By Superoxide ( O 2 à ) Anmentioning

confidence: 99%

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Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms

2003

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In the past few years, nuclear DNA damage-sensing mechanisms activated by ionizing radiation have been identified, including ATM/ATR and the DNA-dependent protein kinase. Less is known about sensing mechanisms for cytoplasmic ionization events and how these events influence nuclear processes. Several studies have demonstrated the importance of cytoplasmic signaling pathways in cytoprotection and mutagenesis. For cytoplasmic signaling, radiation-stimulated reactive oxygen species (ROS) and reactive nitrogen species (RNS) are essential activators of these pathways. This review summarizes recent studies on the chemistry of radiation-induced ROS/ RNS generation and emphasizes interactions between ROS and RNS and the relative roles of cellular ROS/ RNS generators as amplifiers of the initial ionization events. Cellular mechanisms for regulating ROS/RNS levels are discussed. The mechanisms by which cells sense ROS/RNS are examined in terms of how ROS/RNS modify protein structure and function, for example, interactions with metal-thiol clusters, protein tyrosine nitration, protein cysteine oxidation, S-thiolation and Snitrosylation. We propose that radiation-induced ROS are the initiators and that nitric oxide (NO ) or derivatives are the effectors activating these signal transduction pathways. In responding to cellular ionization events, the cell converts an oxidative signal to a nitrosative one because ROS are too reactive and unspecific in their reactions for regulatory purposes and the cell is equipped to precisely modulate NO levels.

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Section: Oxidation and Nitration Initiated By Superoxide ( O 2 à ) Anmentioning

confidence: 99%

Section: Oxidation and Nitration Initiated By Superoxide ( O 2 à ) Anmentioning

confidence: 99%

Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms

2003

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“…Myeloperoxidase, a green hemoprotein enzyme, can use H2O2 generated by NADPH oxidase to oxidize halides (Cl ) to their corresponding hypohalous acids (an additional class of active oxygen metabolite) (34). In the present study isoproterenol administration showed a significant increase in myocardial MPO levels and C-reactive proteins, indicative of necrosis-induced inflammation of myocardial tissue and neutrophil infiltration.…”

Section: Discussionmentioning

confidence: 50%

Cardio Protective Effect of Vitamin A against Isoproterenol-Induced Myocardial Infarction

Pipaliya¹,

Vaghasiya²

2012

J Nutr Sci Vitaminol

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Summary Vitamin A is beneficial in counteracting free radical damage, therefore the present study is designed to investigate the effect of vitamin A against isoproterenol-induced myocardial infarction in rats. Male Wistar rats were divided into three groups, namely a normal control group, an isoproterenol group (150 mg/kg, s.c.), and a vitamin A treatment (4,500 IU/kg/d, orally) group. Vitamin A-treated rats demonstrated significant reduction in ST-segment (p,0.001) and infarct sizes (p,0.05) when compared with the isoproterenol group of rats, suggesting that vitamin A markedly attenuated myocardial injury. Vitamin A treatment resulted in a significant decrease in the serum level of troponin I (p,0.001), creatinine kinase-MB (p,0.01), creatine kinase (p,0.05), lactate dehydrogenase (p,0.05), aspartate aminotransferase (p,0.01) and alanine aminotransferase (p,0.01). Vitamin A treatment resulted in a significant decrease in malondialdehyde (p,0.001), and significant increases were observed in reduced glutathione (p,0.01), superoxide dismutase (p,0.05) and catalase (p,0.001). Vitamin A treatment resulted in a significantly increased level of Na ATPase (p,0.01). Vitamin A treatment also demonstrated a significantly decreased level of C-reactive protein (p,0.05) and myeloperoxidase activity (p,0.01). In conclusion, vitamin A attenuated the myocardial infarction and prevention was shown via membrane stabilization, reduction in oxidative stress, and prevention of neutrophil infiltration.

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“…Recently, a second pathway for tyrosine nitration has been suggested. This involves the neutrophil enzyme myeloperoxidase (MPO) (Kettle et al, 1997;Burner et al, 2000;Baldus et al, 2002;Brennan et al, 2002;Gaut et al, 2002). MPO is released when neutrophils are stimulated during inflammatory reaction.…”

Section: Figure 2 : Evolution Of the Least-squares Means Of The Plasmmentioning

confidence: 99%

“…Peptide or protein nitration can result from the reaction of aromatic amino acid residues with peroxynitrite anion (ONOO -), a strong oxidant formed by the reaction of nitric oxide (·NO) with superoxide anion (O2 -) (Beckman et al, 1994) or from the activity of the oxidant enzyme myeloperoxidase (Kettle et al, 1997;Burner et al, 2000;Baldus et al, 2002). Tyrosine is an aromatic amino acid residue that is particularly sensitive to nitration (Van der Vliet et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Plasma Concentrations of a Type II Collagen-derived Peptide and Its Nitrated Form in Growing Ardenner Sound Horses and in Horses Suffering from Juvenile Digital Degenerative Osteoarthropathy

Lejeune¹,

Serteyn

Gangl

et al. 2007

Vet Res Commun

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Several breeds of draft horses suffer from degenerative digital osteoarthropathy, resulting in a reduced active lifespan. A group of 30 Ardenner horses was followed, in standardized conditions, from 15 to 28 months of age to detect the early manifestations of the disease. The severity of the disease was assessed according to a personal grading system including clinical and radiographic items. Coll 2-1, a peptide of the helical region of type II collagen, and its nitrated form (Coll 2-1 NO 2 ) were assayed in blood plasma collected at 452 ± 18 days, 504 ± 20 days, 558 ± 18 days, 613 ± 19 days, 675 ± 19 days, 752 ± 21 days and 852 ± 19 days of age. At the end of the follow-up period, 53.3% of Ardenner horses were affected by a degenerative digital osteoarthropathy. A significant effect (p < 0.05) of time, sex and pathology was observed for Coll 2-1 NO 2 . Variations of Coll 2-1 were not significant except for the time effect. The elevation of Coll 2-1 NO 2 in the pathological group could indicate an inflammatory process during the growth of the affected horses, as nitration of tyrosine is mediated through reactive oxygen/nitrogen species and/or myeloperoxidase activity. Coll 2-1 NO 2 appears to be an interesting early marker of cartilage degradation and oxidation in degenerative osteoarthropathy.

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Peroxynitrite and myeloperoxidase leave the same footprint in protein nitration

Cited by 91 publications

References 15 publications

Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms

Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms

Cardio Protective Effect of Vitamin A against Isoproterenol-Induced Myocardial Infarction

Plasma Concentrations of a Type II Collagen-derived Peptide and Its Nitrated Form in Growing Ardenner Sound Horses and in Horses Suffering from Juvenile Digital Degenerative Osteoarthropathy

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