Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages

Muscoli, Carolina; Salvemini, Daniela; Paolino, Donatella; Iannone, Michelangelo; Palma, Ernesto; Cufari, Antonio; Rotiroti, Domenicantonio; Perno, Carlo Federico; Aquaro, Stefano; Mollace, Vincenzo

doi:10.1186/1471-2202-3-13

Cited by 14 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of HIV in inducing neuronal damage is deeply described in several works [ 1 , 64 , 65 , 66 , 67 , 68 ]. Most of these papers focused their attention on the role of the HIV-1 regulatory proteins in this phenomenon ( Table 2 ).…”

Section: The Role Of Hiv-1 Proteins In Handmentioning

confidence: 99%

The Role of HIV Infection in Neurologic Injury

et al. 2017

Self Cite

View full text Add to dashboard Cite

The central nervous system (CNS) is a very challenging HIV-1 sanctuary, in which HIV-1 replication is established early on during acute infection and can persist despite potent antiretroviral treatments. HIV-1 infected macrophages play a pivotal role acting as vehicles for HIV-1 to spread into the brain, and can be the major contributor of an early compartmentalization. HIV-1 infection in CNS may lead to a broad spectrum of neurological syndromes, such as dementia, mild neurocognitive disorders, and asymptomatic impairment. These clinical manifestations are caused by the release of neurotoxins from infected cells (mainly macrophages), and also by several HIV-1 proteins, able to activate cell-signaling involved in the control of cellular survival and apoptosis. This review is aimed at highlighting the virological aspects associated with the onset of neurocognitive disorders and at addressing the novel therapeutic approaches to stop HIV-1 replication in this critical sanctuary.

show abstract

Section: The Role Of Hiv-1 Proteins In Handmentioning

confidence: 99%

The Role of HIV Infection in Neurologic Injury

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…The exact role of nitric oxide (NO°) in HIV-1 infection is still under controversy [13]. NO° is known to possess antiviral effects, but there is also some evidence that it may activate HIV-1 replication and promote apoptosis via the formation of peroxynitrite [14]. accumulating evidence to support the beneficial effect of NAC.…”

Section: The Role Of Oxidative Stress In Hiv Diseasementioning

confidence: 99%

Anti-HIV Activities of Natural Antioxidant Caffeic Acid Derivatives: Toward an Antiviral Supplementation Diet

Bailly¹,

Cotelle

2005

CMC

View full text Add to dashboard Cite

Since 1996, highly active antiretroviral therapy (HAART) was designed to rapidly control HIV replication. It has had a significant impact on patient health and progression of AIDS in developed countries, but its success has not been complete. HAART strategy still suffers from issues of patient compliance, cost, deleterious side effects and emerging drug resistance. Therefore, expansion of novel anti-HIV drugs and targets will be critical in the coming years. In this context, discovering anti-HIV agents from natural sources and particularly from plants, may highlight the principle of a nutritional antioxidant antiretroviral diet. In this paper, we review the putative anti-HIV activity of simple caffeic acid derivatives, together with their antioxidant properties. Toxicity, metabolism and bioavailability, when known, will also be detailed. Well-known caffeic acid derivatives, such as chicoric, rosmarinic and lithospermic acids, may be designed as future leads multi-target anti-HIV compounds and the plants and vegetables containing them as potent nutritional therapeutic supplementation source. They are not expected to replace the actual antiretroviral therapy, but more likely, to complete and perhaps lighten it by adapted diet.

show abstract

“…Oxidative events produce stresses that increase neuronal apoptosis, even in the absence of HIV-1 infection. It has been found that oxidative stress has a crucial function in a number of other neurodegenerative diseases [48].…”

Section: Pathology Of Neuroaidsmentioning

confidence: 99%

Crucial Role of Central Nervous System as a Viral Anatomical Compartment for HIV-1 Infection

et al. 2021

Self Cite

View full text Add to dashboard Cite

The chronic infection established by the human immunodeficiency virus 1 (HIV-1) produces serious CD4+ T cell immunodeficiency despite the decrease in HIV-1 ribonucleic acid (RNA) levels and the raised life expectancy of people living with HIV-1 (PLWH) through treatment with combined antiretroviral therapies (cART). HIV-1 enters the central nervous system (CNS), where perivascular macrophages and microglia are infected. Serious neurodegenerative symptoms related to HIV-associated neurocognitive disorders (HAND) are produced by infection of the CNS. Despite advances in the treatment of this infection, HAND significantly contribute to morbidity and mortality globally. The pathogenesis and the role of inflammation in HAND are still incompletely understood. Principally, growing evidence shows that the CNS is an anatomical reservoir for viral infection and replication, and that its compartmentalization can trigger the evolution of neurological damage and thus make virus eradication more difficult. In this review, important concepts for understanding HAND and neuropathogenesis as well as the viral proteins involved in the CNS as an anatomical reservoir for HIV infection are discussed. In addition, an overview of the recent advancements towards therapeutic strategies for the treatment of HAND is presented. Further neurological research is needed to address neurodegenerative difficulties in people living with HIV, specifically regarding CNS viral reservoirs and their effects on eradication.

show abstract

Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages

Cited by 14 publications

References 30 publications

The Role of HIV Infection in Neurologic Injury

The Role of HIV Infection in Neurologic Injury

Anti-HIV Activities of Natural Antioxidant Caffeic Acid Derivatives: Toward an Antiviral Supplementation Diet

Crucial Role of Central Nervous System as a Viral Anatomical Compartment for HIV-1 Infection

Contact Info

Product

Resources

About