2007
DOI: 10.1152/ajpheart.00800.2006
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Peroxynitrite diminishes myogenic tone in cerebral arteries: role of nitrotyrosine and F-actin

Abstract: Maneen MJ, Cipolla MJ. Peroxynitrite diminishes myogenic tone in cerebral arteries: role of nitrotyrosine and F-actin.

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Cited by 43 publications
(39 citation statements)
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“…After I/R, the vasodilatation caused by this factor was enhanced in MCA from normotensive rats (31). Furthermore, the loss of tone after I/R was associated with a decrease in vascular smooth muscle F-actin (10), likely due to an increase of peroxynitrite production (29,30). Moreover, the observation that I/R induced vasodilatation also in contralateral vessels from this rat strain supports the participation of systemic factor(s) derived from focal ischemia.…”
Section: Discussionmentioning
confidence: 81%
“…After I/R, the vasodilatation caused by this factor was enhanced in MCA from normotensive rats (31). Furthermore, the loss of tone after I/R was associated with a decrease in vascular smooth muscle F-actin (10), likely due to an increase of peroxynitrite production (29,30). Moreover, the observation that I/R induced vasodilatation also in contralateral vessels from this rat strain supports the participation of systemic factor(s) derived from focal ischemia.…”
Section: Discussionmentioning
confidence: 81%
“…Peroxynitrite may be an important mediator of cellular injury through several effects, including the activation of PARP (24,26,27,33). Excessive activation of PARP can deplete cellular energy pools and thus produce cellular dysfunction (24,33).…”
Section: Discussionmentioning
confidence: 99%
“…Peroxynitrite can have both beneficial and deleterious effects depending on the amount generated. At relatively high concentrations (micromolar), peroxynitrite can induce oxidative and nitrosative damage in brain and blood vessels and leads to cerebrovascular dysfunction (Maneen and Cipolla, 2007). However, at low concentrations (nanomolar), peroxynitrite activates protective stress pathways (Akt and MAP kinase), induces vasodilation, and inhibits leukocyte adhesion (Wei et al, 1996;Lefer et al, 1997;Nossuli et al, 1997;Klotz et al, 2002;Li et al, 2004).…”
Section: Discussionmentioning
confidence: 99%