Thanks to the increase of mobile terminal devices, mobile games have gradually become an important part of human life. People use games to please themselves or kill time. The user interface of excellent games can attract users or make it easier for users to immerse in them. By studying the changes in the game user interface from its birth to the present, this paper discusses the internal reasons for its changes and the future development direction. This paper studies the game user interface in the era of the Saipan system and the era of smart machines through qualitative methods and discusses the current mainstream game user interface types. Through research, it is found that the mobile phone hardware has a serious impact on the game user interface, and as the mobile phone screen gradually becomes larger, the game user interface can present more content, and the interaction between the user and the game system also presents a variety of modes.