Persistence, adherence, and effectiveness of combination therapy among adult patients with asthma

Asthma inhaler adherence determinants in adults: systematic review of observational data

“…For ICS/LABA therapy, persistence was less likely for adults compared to children, for people with longer therapy duration, higher daily dose, and having used antibiotics in the previous year [56]. Patients using ICS/LABA were more likely to persist with therapy compared to those using ICS+LABA, as were male patients, older patients, those receiving social assistance, those with lower daily dosage, those receiving prescriptions from a specialist, and those using more medications currently and in the previous year [50]. Time to discontinuation of ICS/LABA therapy was longer for male patients, older patients, those paying moderately for treatment, having more refills included in the first prescription, having prescriptions for other conditions, and having had relievers prescribed before the start of the study [47].…”

Does use of a corticosteroid/long-acting beta-agonist combination inhaler increase adherence to inhaled corticosteroids?

“…Although there is some evidence on adherence in relation to ICS/LABA inhalers from north America, 4 this is the first UK primary care study. The low response rate (one in six) clearly limits the generalisability of this study.…”

Real life profile of asthma and chronic obstructive pulmonary disease patients in Turkey

“…Although treatment success in asthma and COPD is largely dependent upon medication adherence, suboptimal disease management, including the failure of physicians to adhere to treatment guidelines, also plays a part (28). Good adherence is associated with reduced exacerbation rates in patients with asthma and COPD (29)(30)(31). A subgroup analysis of the TORCH (Towards a Revolution in COPD Health) study showed that good compliance to study medication in patients with COPD was associated with lower mortality rates compared with poor compliance (11.3% vs. 26.4%) (32).…”