Persistence and resolution of suicidal ideation during treatment of depression in patients with significant suicidality at the beginning of treatment: The CRESCEND study

Seo, Ho Jun; Jung, Young Eun; Jeong, Seok–Hwan; Kim, Jung Bum; Lee, Min-Soo; Kim, Jae Min; Yim, Hyeon Woo; Jun, Tae-Won

doi:10.1016/j.jad.2013.11.002

Cited by 18 publications

(19 citation statements)

References 42 publications

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“…Multiple, uncontrolled treatments can limit the interpretative validity of results. In a previous study, persistent suicidality was associated with treatment with selective serotonin reuptake inhibitors, a higher baseline SSI-B score and no HAMD- or HAMA-indexed remission episodes [57] . The present results should be interpreted in this context.…”

Section: Discussionmentioning

confidence: 80%

Relationship of Temperament and Character in Remitted Depressed Patients with Suicidal Ideation and Suicide Attempts—Results from the CRESCEND Study

et al. 2014

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The aim of this study was to evaluate the Temperament and Character Inventory (TCI) scores of a sample of Korean patients with remitted depression who had attempted suicide and reported suicidal ideation and to compare their scores with those of remitted depressed patients without suicidal ideation. Adult depression patients who had completed 12 weeks of follow-up (N = 138) were divided into three groups: patients with a history of suicide attempts (N = 23); patients with current suicidal ideation (N = 59); and patients without current suicidal ideation (N = 56). After controlling for covariates, no significant differences were found among the three groups on any measure of temperament or character except self-directedness and self-transcendence. The self-transcendence scores of the lifetime suicide-attempt group were significantly higher compared with those of the suicidal-ideation group; post hoc analysis revealed that self-directedness was significantly lower in the suicide-attempt group compared with the non-suicidal group. The results from the present study suggest that remitted depression patients with a history of suicide attempts do not differ from non-attempters in temperament, but do differ in certain character traits.

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Section: Discussionmentioning

confidence: 80%

Relationship of Temperament and Character in Remitted Depressed Patients with Suicidal Ideation and Suicide Attempts—Results from the CRESCEND Study

et al. 2014

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“…Patients suffering from severe depression are already at high risk for committing suicide (up to 15% [ ref. 42 ]). A patient not responding to DBS might lose any hope of recovery, as DBS is often regarded as a last resort.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, suicidal ideation might persist even when treatment reduces depressive symptoms in general. 42 Other DBS for TRD trials have also reported completed suicides, 12 , 43 although suicide rates remained below those of severe MDD patients without DBS. 44 The intense follow-up provided after DBS implantation might protect against suicide.…”

Section: Discussionmentioning

confidence: 99%

Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up

et al. 2017

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We previously found that electrical stimulation in the anterior limb of the internal capsule/bed nucleus of the stria terminalis (IC/BST) alleviates depressive symptoms in severe treatment-resistant obsessive-compulsive disorder (OCD) patients. Here we tested the hypothesis that electrical stimulation in either IC/BST or in the inferior thalamic peduncle (ITP) effectively reduces depressive symptoms in treatment-resistant major depressive disorder (TRD). In a double-blind crossover design, the effects of electrical stimulation at both targets were compared in TRD patients. The 17-item Hamilton Depression Rating scale (HAM-D) was the primary outcome measure. During the first crossover, patients received IC/BST stimulation versus no stimulation in random order (2 × 1 weeks). During the second crossover (3 × 2 months), patients received IC/BST versus ITP versus no stimulation. Patients and evaluators were blinded for stimulation conditions. All patients (n=7) were followed up for at least 3 years (3–8 years) after implantation. Six patients completed the first crossover and five patients completed the second. During the first crossover, mean (s.d.) HAM-D scores were 21.5 (2.7) for no stimulation and 11.5 (8.8) for IC/BST stimulation. During the second crossover, HAM-D scores were 15.4 (7.5) for no stimulation, 7.6 (3.8) for IC/BST stimulation and 11.2 (7.5) for ITP stimulation. The final sample size was too small to statistically analyze this second crossover. At last follow-up, only one patient preferred ITP over IC/BST stimulation. Two patients, with a history of suicide attempts before implantation, committed suicide during the follow-up phases of this study. Our data indicate that, in the long term, both ITP and IC/BST stimulation may alleviate depressive symptoms in patients suffering from TRD.

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“…To explain the persistence of depressive symptoms and suicidality despite being treated, first, onethird to half of patients were reported as 'treatment-resistant' in past studies [33,34] and only twothird of patients recovered from depression within 6 months [16]. It was speculated that those nonresponsive patients had a chronicity of symptoms that lead to suicidality, as shown in a study conducted in Korea [35] that found that 63% of patients presented persistent suicidality after a 12-…”

Section: Resultsmentioning

confidence: 99%

Suicidality and associated social, demographic and clinical factors in Thai patients with acutely treated depressive disorder: a cross-sectional study

Chiddaycha

Lueboonthavatchai²

2020

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Background Some depressed people die by suicide although they are in treatment. The aims of this study were to examine the prevalence of suicidality and to identify the associated social, demographic and clinical factors in Thai patients with acutely treated depressive disorders.Patients and methods A sample of 178 in- and outpatients with depressive disorders who were treated within the six-month period of being diagnosed or of a recurrent episode were recruited from a tertiary hospital during November 2017 to April 2018. The associations between suicide risks assessed using the suicidality module of the Mini-International Neuropsychiatric Interview (MINI) and various factors including demographic data, depressive severity, interpersonal problems, social support, family relationships, and life stress events were analyzed by chi-square test. Logistic regression was used for identification of the potential predictors of moderate-to-high suicide risk.Results Most of the subjects were single (80.9%), female (68%), and in early adulthood (mean age 28.9, SD 11.2). The prevalence of suicidal ideation, suicide attempt within one month, and previous history of suicide attempt during lifetime were 62.4%, 35.4% and 41%, respectively. The prevalence of suicidality (76.4%) and moderate-to-high suicide risk (48.4%) were high. The factors associated with moderate-to-high suicide risk were lower age, no religion, unemployment, history of substance use within one year, moderate-to-severe level of depression, being an in-patient, short duration of treatment, receiving benzodiazepines, having interpersonal role disputes, having interpersonal deficits, low social support, poor family relationships and functioning, and high severity level of health stress events. Potential predictors of moderate-to-high suicide risk were moderate-to-severe levels of depression, poor family relationships and functioning, age of 20 or lower, being an in-patient, and receiving benzodiazepines.Conclusion The prevalence of suicidality in patients with acutely treated depressive disorder was found to be high. Depressive severity and social factors such as poor family relationships were highly associated with suicide risk. Knowledge of these factors may raise awareness of suicide prevention during the course of treatment of depression.

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Persistence and resolution of suicidal ideation during treatment of depression in patients with significant suicidality at the beginning of treatment: The CRESCEND study

Cited by 18 publications

References 42 publications

Relationship of Temperament and Character in Remitted Depressed Patients with Suicidal Ideation and Suicide Attempts—Results from the CRESCEND Study

Relationship of Temperament and Character in Remitted Depressed Patients with Suicidal Ideation and Suicide Attempts—Results from the CRESCEND Study

Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up

Suicidality and associated social, demographic and clinical factors in Thai patients with acutely treated depressive disorder: a cross-sectional study

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