2022
DOI: 10.3390/ijms24010450
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Persistence Infection of TGEV Promotes Enterococcus faecalis Infection on IPEC-J2 Cells

Abstract: Transmissible gastroenteritis virus (TGEV) is a coronavirus causing diarrhea with high incidence in swine herds. Its persistent infection might lead to epithelial-mesenchymal transition (EMT) of swine intestinal epithelial cells, followed by subsequent infections of other pathogens. Enterococcus faecalis (E. faecalis) is a member of the enteric microorganisms and an opportunistic pathogen. There is no report of secondary E. faecalis infection to TGEV, even though they both target to the intestinal tracts. To i… Show more

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Cited by 2 publications
(3 citation statements)
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“…Thus, in this agriculturally relevant in vitro model, our data suggest that hypoxia may be a driving factor in HS-induced barrier dysfunction. The IPEC-J2 cell line used herein is a non-transformed small intestinal cell line derived from neonatal pigs and has been shown to be a good model for studying nutrition (Rhoads et al, 1994;Yan and Ajuwon, 2017), bacterial invasion (Duan et al, 2022), viral infection (Guo et al, 2022), toxins (Li et al, 2022), and environmental factors such as HS (Cao et al, 2016) and hypoxia (Chapman et al, 2012). Under standard cell culture conditions, cells are typically grown at 37°C.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Thus, in this agriculturally relevant in vitro model, our data suggest that hypoxia may be a driving factor in HS-induced barrier dysfunction. The IPEC-J2 cell line used herein is a non-transformed small intestinal cell line derived from neonatal pigs and has been shown to be a good model for studying nutrition (Rhoads et al, 1994;Yan and Ajuwon, 2017), bacterial invasion (Duan et al, 2022), viral infection (Guo et al, 2022), toxins (Li et al, 2022), and environmental factors such as HS (Cao et al, 2016) and hypoxia (Chapman et al, 2012). Under standard cell culture conditions, cells are typically grown at 37°C.…”
Section: Discussionmentioning
confidence: 99%
“…The current knowledge base is still quite new. The IPEC-J2 cell line, which is a nontransformed small intestinal cell line derived from neonatal pigs, has been shown to be a good model to study nutrition (Rhoads et al, 1994;Yan and Ajuwon, 2017), bacterial invasion (Duan et al, 2022), viral infection (Guo et al, 2022), toxins (Li et al, 2022), and environmental factors such as HS (Cao et al, 2016) and hypoxia (Chapman et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…It is also a conditional pathogen that has been recognized as an important cause of nosocomial infections increasingly. Similarly, it can cause related infections, including bacteremia, bacterial endocarditis, amyloid arthropathy, diarrhea and gastrointestinal inflammation ( Cauwerts et al, 2007 ; Gregersen et al, 2010 ; Fan et al, 2021 ; Guo et al, 2022 ). Recently, multidrug-resistant E. faecalis has been frequently reported ( Kang et al, 2021 ; Stȩpień-Pyśniak et al, 2021 ; Yoon and Lee, 2021 ; Shan et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%