Persistence of hepatitis E virus in the cerebrospinal fluid despite apparently successful ribavirin therapy

Lhomme, Sébastien; Fayard, Amandine; Mirafzal, Sonia; Carcenac, Romain; Boyer, Pauline; Latour, Justine; Brebion, Amélie; Bay, Jacques‐Olivier; Henquell, Cécile; Izopet, Jacques

doi:10.1093/jac/dkac147

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…This hypothesis is supported by the association between a high level of intrahost HEV diversity (in ORF1 and ORF2 regions) and evolution toward chronic hepatitis E. 18 , 25 In addition, a compartmentalization of HEV quasi-species was observed between the blood and cerebrospinal fluid in patients with chronic hepatitis E. 26 , 27 Such compartmentalization argue for extrahepatic HEV replication in the central nervous system, in line with other clinical and in vitro studies. 28 , 29 , 30 Recent studies suggested that HEV could also replicate in human intestines. Indeed, HEV can replicate in enterocytes in vitro and be detected in intestinal tissue samples from patients with chronic HEV infection.…”

mentioning

confidence: 99%

Relevance of Tacrolimus Trough Concentration and Hepatitis E virus Genetic Changes in Kidney Transplant Recipients With Chronic Hepatitis E

León-Janampa,

Boennec,

Le Tilly

et al. 2024

Kidney International Reports

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mentioning

confidence: 99%

Relevance of Tacrolimus Trough Concentration and Hepatitis E virus Genetic Changes in Kidney Transplant Recipients With Chronic Hepatitis E

León-Janampa,

Boennec,

Le Tilly

et al. 2024

Kidney International Reports

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Puzzles for Hepatitis E Virus

Wang,

Zhuang

2023

Advances in Experimental Medicine and Biology

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Serological indication of chronic inflammatory demyelinating polyneuropathy as an extrahepatic manifestation of hepatitis E virus infection

Pischke,

Kjasimov,

Skripuletz

et al. 2024

Sci Rep

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Guillain–Barré syndrome and neuralgic amyotrophy have been associated with hepatitis E virus (HEV) genotype 3 infections, while myasthenia gravis (MG) has been associated with HEV genotype 4 infections. However, whether chronic inflammatory demyelinating polyneuropathy (CIDP) is associated with HEV infections has not been conclusively clarified yet. 102 CIDP patients, 102 age- and sex-matched blood donors, 61 peripheral neuropathy patients (non-CIDP patients), and 26 MG patients were tested for HEV and anti-HEV IgM and IgG. Sixty-five of the 102 (64%) CIDP patients tested positive for anti-HEV IgG and one (1%) for anti-HEV IgM. No other patient tested positive for ati-HEV IgM. In the subgroup of CIDP patients with initial diagnosis (without previous IVIG treatment), 30/54 (56%) tested positive for anti-HEV IgG. Anti-HEV rates were significantly lower in blood donors (28%), non-CIDP peripheral neuropathy patients (20%), and MG patients (12%). No subject tested positive for HEV viremia. CSF tested negative for in 61 CIDP patients (54 patients with primary diagnosis). The development of CIDP but not non-CIDP polyneuropathy may be triggered by HEV exposure in an HEV genotype 3 endemic region. The increased anti-HEV seroprevalence in CIDP patients is not a consequence of IVIG therapy.

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Persistence of hepatitis E virus in the cerebrospinal fluid despite apparently successful ribavirin therapy

Cited by 5 publications

References 7 publications

Relevance of Tacrolimus Trough Concentration and Hepatitis E virus Genetic Changes in Kidney Transplant Recipients With Chronic Hepatitis E

Relevance of Tacrolimus Trough Concentration and Hepatitis E virus Genetic Changes in Kidney Transplant Recipients With Chronic Hepatitis E

Puzzles for Hepatitis E Virus

Serological indication of chronic inflammatory demyelinating polyneuropathy as an extrahepatic manifestation of hepatitis E virus infection

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