Persistence of human parvovirus B19 in human tissues

Söderlund‐Venermo, Maria; Hokynar, Kati; Nieminen, Janne; Rautakorpi, Henna; Hedman, Klaus

doi:10.1016/s0369-8114(02)00307-3

Cited by 142 publications

(106 citation statements)

References 89 publications

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“…Serodiagnostics (i.e., IgG seropositivity; IgG avidity, IgG epitope type specificity, and the absence of IgM ruling out recent primary infection) verified the specificity of the original findings and showed the DNA persistence in synovium to be long (24,27). Besides revolutionizing the diagnostic criteria of parvovirus arthropathy (28,29), the tissue persistence has evoked wide interest in the possible etiopathogenic role of these viruses in inflammatory and other chronic diseases (30)(31)(32)(33)(34)(35)(36). However, the substantial span of the viral genome persistence as well as its cellular and molecular mechanisms remained undefined.…”

mentioning

confidence: 71%

Bioportfolio: Lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue

Norja

Hokynar

Aaltonen³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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216

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Human erythrovirus is a minute, single-stranded DNA virus causing many diseases, including erythema infectiosum, arthropathy, and fetal death. After primary infection, the viral genomes persist in solid tissues. Besides the prototype, virus type 1, two major variants (virus types 2 and 3) have been identified recently, the clinical significance and epidemiology of which are mostly unknown. We examined 523 samples of skin, synovium, tonsil, or liver (birth year range, 1913-2000), and 1,640 sera, by qualitative and quantitative molecular assays for the DNA of human erythroviruses. Virus types 1 and 2 were found in 132 (25%) and 58 (11%) tissues, respectively. DNA of virus type 1 was found in all age groups, whereas that of type 2 was strictly confined to those subjects born before 1973 (P < 0.001). Correspondingly, the sera from the past two decades contained DNA of type 1 but not type 2 or 3. Our data suggest strongly that the newly identified human erythrovirus type 2 as well as the prototype 1 circulated in Northern and Central Europe in equal frequency, more than half a century ago, whereafter type 2 disappeared from circulation. Type 3 never attained wide occurrence in this area during the past >70 years. The erythrovirus DNA persistence in human tissues is lifelong and represents a source of information about our past, the Bioportfolio, which, at the individual level, provides a registry of one's infectious encounters, and at the population level, a database for epidemiological and phylogenetic analyses.epidemiology ͉ gene therapy ͉ parvovirus ͉ phylogeny ͉ single-stranded DNA

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mentioning

confidence: 71%

Bioportfolio: Lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue

Norja

Hokynar

Aaltonen³

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

253

216

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“…However, emerging evidence challenges this notion. With the use of sensitive quantitative techniques such as dot blot and nested PCR assays, B19 DNA has been detected in bone marrow and in peripheral blood for months and even years in seemingly immunocompetent individuals, despite the presence of neutralizing antibody (29,30). The clinical significance of this delayed clearance and low-level viremia is unknown.…”

Section: Pathogenesis and Immune Responsementioning

confidence: 99%

“…For example, what is the clinical significance of the detection of viral DNA in nonerythroid cells such as in the kidney? It has been shown that B19 DNA can remain detectable by nucleic acid amplification testing in a variety of tissues (30), including bone marrow (66), synovial tissue (67), and skin (6), for extended periods without evidence of disease in some (30). As discussed, viral DNA has been detected in seemingly "normal, control" kidneys (50).…”

Section: Glomerular Diseases Associated With Parvovirusmentioning

confidence: 99%

Parvovirus B19 and the Kidney

Waldman¹,

Kopp²

2007

Clinical Journal of the American Society of Nephrology

116

105

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“…Parvovirus B19 (B19) is a common virus with significant pathology (7). As B19 is regarded as a typical "hit-and-run" virus, the humoral response plays a well-documented role for viral neutralization, but there is also evidence that low-level persistence can occur in certain cases (21,27). Cellular immune responses have also recently been described, both CD4 ϩ proliferative-and CD8 ϩ cytotoxic-T-cell responses, with one HLA-B35-restricted epitope characterized so far (4,5,28).…”

Section: The Emergence Of New Tools For the Ex Vivo Analysis Of Cellumentioning

confidence: 99%

Sustained CD8 ⁺ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans

Norbeck

Isa

Pöhlmann

et al. 2005

J Virol

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Murine models have suggested that CD8؉ T-cell responses peak early in acute viral infections and are not sustained, but no evidence for humans has been available. To address this, we longitudinally analyzed the CD8 ؉ T-cell response to human parvovirus B19 in acutely infected individuals. We observed striking CD8 ؉ T-cell responses, which were sustained or even increased over many months after the resolution of acute disease, indicating that CD8 ؉ T cells may play a prominent role in the control of parvovirus B19 and other acute viral infections of humans, including potentially those generated by live vaccines.

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Persistence of human parvovirus B19 in human tissues

Cited by 142 publications

References 89 publications

Bioportfolio: Lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue

Bioportfolio: Lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue

Parvovirus B19 and the Kidney

Sustained CD8 ⁺ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans

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Persistence of human parvovirus B19 in human tissues

Cited by 142 publications

References 89 publications

Bioportfolio: Lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue

Bioportfolio: Lifelong persistence of variant and prototypic erythrovirus DNA genomes in human tissue

Parvovirus B19 and the Kidney

Sustained CD8 + T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans

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Sustained CD8 ⁺ T-Cell Responses Induced after Acute Parvovirus B19 Infection in Humans