Persistence of human T cell lymphotropic virus type 1 (HTLV-1) sequences in peripheral blood mononuclear cells from patients with mycosis fungoides.

Manca, N.; E, Piacentini; Gelmi, M; Calzavara, P; Manganoni, Maria Ausilia; Глухов, А.И.; Gargiulo, Franco; Francesco, Maria Antonia De; Pirali, F; Panfilis, G. De; Turano, A

doi:10.1084/jem.180.5.1973

Cited by 34 publications

(17 citation statements)

References 21 publications

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“…Some cases may represent misdiagnosis of MF in patients with smouldering ATLL. However, most cases of ATLL are seropositive and most reported cases of HTLV-I in CTCL are in seronegative individuals (D'Incan et al, 1990;Dave et al, 1995;Fouchard et al, 1995;Ghosh et al, 1994;Hall et al, 1991;Lisby et al, 1992;Manca et al, 1994;Pancake et al, 1995;Whittaker & Luzatto, 1993;ZuckerFranklin et al, 1991ZuckerFranklin et al, , 1992. Rare cases of HTLV-I antibody negative ATL have been described (Korber et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Ghosh et al (1994) documented the presence of HTLV-I tax and/or rex proviral sequences in 72% of uncultured peripheral blood mononuclear cells (PBMCs) and 80% of T-cell lines derived from patients with SS. The same year, Manca et al (1994) found PCR amplification of HTLV-I pol and pX regions in cultured cells from 10/29 Italian patients with MF. In contrast, at least six reports fail to confirm these observations (Table I) (Abrams et al, 1991;Bazarbachi et al, 1993;Capesius et al, 1991;Lisby et al, 1992;Moudgil et al, 1994;Pombo de Oliviera et al, 1995;Vallejo et al, 1995).…”

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confidence: 99%

“…Association between mycosis fungoides (MF) (Patterson & Edelson, 1985), its leukaemic variant Sezary syndrome (SS) and the human T-cell lymphotropic virus type I (HTLV-I) (Poiesz et al, 1980) has been controversial, as the reported incidence of infection has varied between 0% and nearly 100% (see Table I) (Abrams et al, 1991;Anagnostopoulos et al, 1990;Bazarbachi et al, 1993;Capesius et al, 1991;Chan et al, 1993;D'Incan et al, 1990;Dave et al, 1995;Fouchard et al, 1995;Ghosh et al, 1994;Hall et al, 1991;Lisby et al, 1992;Manca et al, 1994;Moudgil et al, 1994;Pancake et al, 1995;Pombo de Oliviera et al, 1995;Srivastava et al, 1992;Vallejo et al, 1995;Whittaker & Luzatto, 1993;ZuckerFranklin et al, 1991ZuckerFranklin et al, , 1992. HTLV-I is the aetiologic agent of adult T-cell leukaemia/lymphoma (ATLL) and the majority of patients with this disease are HTLV-I seropositive with clonal integration of the HTLV-I provirus in the leukaemic cells (Takatsuki et al, 1985).…”

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Mycosis fungoides and Sezary syndrome are not associated with HTLV‐I infection: an international study

et al. 1997

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Summary. Association between mycosis fungoides (MF), its leukaemic variant Sezary syndrome (SS) and the human Tcell lymphotropic virus type-I (HTLV-I) has been controversial, with the reported incidence of infection varying between 0% and nearly 100%. We studied 127 patients (85 MF, 28 SS, five Sezary cell leukaemia, four lymphomatoid papulosis, and five unspecified cutaneous T-cell lymphomas (CTCL)) originating from Europe (France, Spain, U.K., Portugal) or from U.S.A. (California) for the presence of HTLV-I infection markers. HTLV-I and -II serology were performed on 78 patients using standard immunological methods. Reverse transcriptase (RT) assay was also performed in 26 cases using an RT-PCR-based method of high sensitivity. Molecular analyses were performed on 215 DNA samples (121 from fresh PBMCs, 26 from PBMCs after short-term culture and 68 from skin lesions) by PCR amplification using HTLV-I and -II gag, pol, env, pX and LTR specific primers.Immunological tests were negative except for two sera which were indeterminate. PCR with all HTLV-I and -II primer pairs showed negative results in all 215 samples investigated. No RT activity was detected in short-term PBMC cultures of any of the 26 cases studied. The results of this large study from five different countries clearly indicate that MF and SS are not associated with HTLV-I infection.

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Section: Discussionmentioning

confidence: 99%

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Mycosis fungoides and Sezary syndrome are not associated with HTLV‐I infection: an international study

et al. 1997

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“…Although viral transformation with human T-cell lymphotropic virus type 1 has been found in some cases of CTCL, 3 it does not seem to be the agent causing MF. 4 Thus, the primary etiology of MF remains to be found.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

Nielsen

Nissen

Gerwien

et al. 2002

Blood

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Mycosis fungoides is a low-grade cutanous T-cell lymphoma (CTCL) of unknown etiology. In advanced stages of CTCL, a shift in cytokine profile from T H 1 to T H 2 is observed, which coincides with eosinophilia, high levels of immunoglobulin E, and increased susceptibility to bacterial infections. It is, however, unknown why T H 2 cytokines predominate in advanced CTCL, and the cellular source of these cytokines also remains to be identified. In several leukemias and lymphomas, constitutively activated signal transducer and activator of transcription (Stat) signaling pathways have been detected. In a previous study, constitutive activation of Stat3 was found in tumor cells isolated from affected skin and blood from CTCL patients. Here, it is shown that CTCL tumor cell lines, but not nonmalignant cell lines, spontaneously produce interleukin-5 (IL-5), IL-6, and IL-13. Transfection of tumor cells with dominantnegative Stat3 almost completely blocks IL-5 production and strongly inhibits IL-13 production, whereas IL-6 production is unaffected. Thus, the data show that malignant CTCL cells themselves might contribute to the change in cytokine pattern accompanying progression of CTCL. In conclusion, constitutively activated Stat3 is found to mediate a spontaneous IL-5 production and regulate IL-13 production in CTCL cell lines, pointing toward a new role of Stat3 in malignant transformation. (Blood. 2002;99:973-977)

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“…12,14 Several groups have thus demonstrated HTLV-I proviral fragments -mostly tax -in DNA extracted from PBMC and/or cutaneous lesions by PCR, in HTLV-I-seronegative SS and MF patients. 17,18,[56][57][58] In Africa, HTLV-I has recently been isolated from a transformed T cell line spontaneously derived from PBMC of a seronegative Egyptian patient with MF. 35 In contrast, other groups failed to detect such HTLV-I sequences in similar patients.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous T cell lymphomas: mycosis fungoides, Sezary syndrome and HTLV-I-associated adult T cell leukemia (ATL) in Mali, West Africa: a clinical, pathological and immunovirological study of 14 cases and a review of the African ATL cases

et al. 1998

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Cutaneous T cell lymphomas (CTCL) are rare lymphoproliferative diseases, which are frequently suspected to be of viral origin. As very few data were available concerning cutaneous T cell lymphomas in tropical Africa, we undertook a clinical, histopathological, immunological and viro-molecular study of patients with a clinical diagnosis of cutaneous lymphoma, in Bamako, Mali. While prior to this study, no case of CTCL had been reported in this country, 14 patients (five women, nine men; mean age 58 years) with a diagnosis of cutaneous lymphoma were seen over a period of 30 months (1992-1994) in the only dermatological department in Mali. Clinically, the most frequent pattern was an infiltrated erythrodermia similar to Sezary syndrome. Nodular lesions and/or plaques were rarely observed. All these cutaneous tumors were T cell lymphoproliferations, only one expressing the CD8 + antigen. A comprehensive analysis of all the available data permitted characterization of three cases of adult T cell leukemia/lymphoma (ATL) associated with HTLV-I (one definitive case, of leukemic type, with demonstration of clonal integration of HTLV-I proviral genome and two probable ATL cases), three cases of Sezary syndrome (SS), two cases of mycosis fungoides (MF) and five cases of pleomorphic cutaneous lymphoma. In one case, the differentiation between MF and pleomorphic cutaneous lymphoma could not be established. HTLV-I serological and/or molecular markers were restricted to the three ATL cases. From the unique definitive ATL case, a T cell line was established from culture of peripheral blood mononuclear cells and sequence analysis of the env gene and the U3-LTR region demonstrated that the virus present in this patient belonged to the cosmopolitan subtype A. Thus, we report here the first evidence of HTLV-I infection and associated ATL in Mali. This is the second ATL case described for the whole Sahelian region (one ATL of the lymphoma type was reported previously in a Mauritanian patient). Furthermore, we demonstrate that the main types of CTCL described in Europe and North America are also present in this African area and that the prevalence of these diseases is greatly underestimated in such regions. Furthermore, no association was observed between HTLV-I/II infection and SS, MF or pleomorphic cutaneous lymphoma in Mali in contrast to other studies.

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Persistence of human T cell lymphotropic virus type 1 (HTLV-1) sequences in peripheral blood mononuclear cells from patients with mycosis fungoides.

Cited by 34 publications

References 21 publications

Mycosis fungoides and Sezary syndrome are not associated with HTLV‐I infection: an international study

Mycosis fungoides and Sezary syndrome are not associated with HTLV‐I infection: an international study

Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

Cutaneous T cell lymphomas: mycosis fungoides, Sezary syndrome and HTLV-I-associated adult T cell leukemia (ATL) in Mali, West Africa: a clinical, pathological and immunovirological study of 14 cases and a review of the African ATL cases

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