Persistence ofLactobacillus reuteriDSM17938 in the Human Intestinal Tract: Response to Consecutive and Alternate-Day Supplementation

Abstract

Alternate-day probiotic intake achieves equivalent colonization to daily intake, but colonization declines rapidly once dosing stops. It is possible that, initially, responsiveness to probiotics may differ between individuals, but those differences do not persist with longer consumption.

Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients - a randomized double-blind placebo-controlled pilot study

“…Although Smith et al postulated that responsiveness to probiotics may vary among individuals; such differences do not persist when probiotics are consumed for longer than 9 days [38]. In our study even after 3 weeks of consumption, the consumed strain was detectable in only 64% of patients, and there were quite large differences in the numbers of gene copies of strain TENSIA.…”

Probiotic Lactobacillus paracasei IMPC 2.1 strain delivered by ready-to-eat swordfish fillets colonizes the human gut after alternate-day supplementation

“…The L. paracasei IMPC 2.1 strain transiently colonized the human gut: it was detected in the faeces of human volunteers after consumption of 5 and 10 portions. Smith, Anderson, Margolis, Sikes, and Young (2011), comparing alternate-day vs consecutive-day intake of pudding enriched with Lactobacillus reuteri, assessed an equivalent gut colonization. Actually, intervention studies are usually based on a daily supplementation of 4 weeks even though there are some indication that faecal bifidobacteria and lactobacilli can be modulated after 7 or 10-days of probiotic intake (Chen, Wu, Lee, Huang, & Wu, 1999;Tuohy et al, 2007).…”

Prophylactic Probiotics to Prevent Death and Nosocomial Infection in Preterm Infants

“…Second, it is possible that the dose of L reuteri that we used was not sufficient to colonize the gut of premature infants or that treatment with antibiotics, which frequently are given to premature infants, did not allow sufficient growth of L reuteri. Smith et al 35 assessed colonization and persistence of L reuteri DSM 17938 after daily or alternate-day dosing (10 9 colony-forming units) and demonstrated fecal recovery of L reuteri was achieved within 4 days and was detected in the feces ∼1 and 2 weeks after supplementation was discontinued. Hakalehto et al 36 demonstrated that L reuteri is resistant to the acid media of the stomach.…”