Persistence of inert macromolecules (imposil) in the rat mesangium and glomerular functional disturbance

Goode, N. P.; Davison, A. M.; Gowland, G.; Aparicio, S. R.; Shires, Michael

doi:10.1002/path.1711440305

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…No increase in serum urea concentration or blood pressure was detected. Other workers have shown that administra tion of exogenous tracer macromolecules which are taken up by glomerular macrophages also results in mild proteinuria with no alteration in glomerular filtration rate (GFR) [10][11][12]. This suggests that proteinuria is a non-specific marker of mesangial macrophage phago cytic activity.…”

Section: Discussionmentioning

confidence: 98%

Cholesterol Feeding Following Unilateral Nephrectomy in the Rat Leads to Glomerular Hypertrophy

Rayner

Ward

Walls

1991

Nephron

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Experimental glomerulosclerosis is associated with hyperlipidaemia and the deposition of lipid in glomeruli. Glomerulosclerosis is typically preceded by glomerular hypertrophy. To investigate a possible pathogenic role of lipids in glomerulosclerosis, glomerular structure and cellular composition were studied in rats fed either a control diet or one supplemented with 4% cholesterol and 1% cholic acid for 21 weeks following unilateral nephrectomy. On the cholesterol diet there were significant increases in glomerular cross-sectional area (13.11 ± 0.39 × 10³ vs. 11.13 ± 0.44 × 10³ μ², p < 0.01) and mesangial area (1.81 ± 0.07 × 10³ vs. 1.50 ± 0.08 × 10³ μ², p < 0.02). These changes were significantly correlated with proteinuria, which was significantly greater on the cholesterol diet (mean area under curve for duration of diet = 3.11 ± 0.38 vs. 1.42 ± 0.35 g, p < 0.02). There was a significant increase in glomerular leukocytes on the cholesterol diet (4.10 ± 0.44 vs. 2.86 ± 0.25 OX-1 positive cells/10⁴ μ², p < 0.05). Mesangial foam cells, derived from macrophages, were associated with adhesions to Bowman’s capsule. These results demonstrate that hyperlipidaemia exacerbates the development of glomerular hypertrophy and that this may be mediated by factors released during the phagocytosis of lipoprotein deposits by macrophages.

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Section: Discussionmentioning

confidence: 98%

Cholesterol Feeding Following Unilateral Nephrectomy in the Rat Leads to Glomerular Hypertrophy

Rayner

Ward

Walls

1991

Nephron

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“…It has been shown that in the mammalian kidney, the glomerular capillary wall and mesangium work to remove the immune complexes, protein aggregates, and inert macromolecular probes passed out across the capillary wall or deposited at various sites of the glomerular tufts (BRENNER et al, 1977;SHARON et al, 1977;PURTELL et al, 1979;TAKAMIYA et al, 1979;MICHAEL et al, 1980;RAIJ, 1980, 1981;CATTELL et al, 1982;STERZEL et al, 1983a, b;GOODE et al, 1984;TSUJII et al, 1985;BERTOLATUS and HUNSICIKER, 1985;SEILER et al, 1986). Fish kidneys also have nephrons, which however accompany hemopoietic tissue provided with melanomacrophage centers (ROBERTS, 1975;ELLIS et al 1978).…”

Section: Discussionmentioning

confidence: 99%

The role of renal macrophages in the aglomerular kidney of the sea-horse (teleost) in the removal of exogenous macromolecules from circulating blood.

Tsujii

1988

Archives of Histology and Cytology

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Uptake and disposal of bsa‐coated latex particles by the rat mesangium: Reaction with subsequently administered heterologous antiserum

Goode

Davison

Gowland

et al. 1985

The Journal of Pathology

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Mesangial uptake and disposal of antigen-coated latex particles and the ability of subsequently injected antibody to maintain complexed antigen in the rat mesangium has been investigated. Carboxylate-modified latex particles, coated with bovine albumin (BSA) were injected i.v. to 36 Wistar rats. Twenty-two rats (group 1) were not treated further. Fourteen rats (group 2) received rabbit anti-BSA antiserum i.v. and i.p. 24 h later. Control groups were injected with uncoated, unmodified latex particles or soluble BSA with and without subsequent antibody administration. Latex was present in the mesangial matrix of rats in group 1 at 1 h in association with a diffuse mesangial distribution of BSA. At 24 h, BSA staining was markedly reduced and extracellular latex was no longer observed. Intracellular latex aggregates were present in experimental and control groups at 24 h-14 days in cytoplasmic vacuoles of hypertrophic mesangium which showed minor infiltration by macrophage-like cells. Progressive removal of latex aggregates coincided with declining mesangial reactivity. Rapid disappearance of antigen apparently results from local degradation of tracer in the mesangium. Antibody administration preserves BSA in the mesangium due to immune complex formation and is associated with retention of ingested latex by mesangial cells. However, efficient disposal of glomerular immune deposits by the mesangium appears to minimize infiltration by monocytes and prevents aggravation of glomerular inflammation.

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Persistence of inert macromolecules (imposil) in the rat mesangium and glomerular functional disturbance

Cited by 3 publications

References 16 publications

Cholesterol Feeding Following Unilateral Nephrectomy in the Rat Leads to Glomerular Hypertrophy

Cholesterol Feeding Following Unilateral Nephrectomy in the Rat Leads to Glomerular Hypertrophy

The role of renal macrophages in the aglomerular kidney of the sea-horse (teleost) in the removal of exogenous macromolecules from circulating blood.

Uptake and disposal of bsa‐coated latex particles by the rat mesangium: Reaction with subsequently administered heterologous antiserum

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