Persistence of infectious mpox virus on the surfaces of isolation ward in a hospital setting, India

Sahay, Rima R.; Relhan, Vineet; Shete, Anita M.; Patil, Deepak Y.; Kumar, L; Kaur, Aneet; Majumdar, Triparna; Agarwal, Deeksha; Gawande, Pranita; Lalmuanpuii, Gaby; Yemul, Jyoti; Bahadur, Anant; Vedpathak, Pratiksha; Guglani, Aditi; MR, Pavani Gowda; Mali, Deepak; Dighe, Hitesh; Sarkale, Prasad; Kumar, Abhinav; Jain, Rajlaxmi; Sahoo, Bijaylaxmi; Kumar, Suresh; Yadav, Pragya

doi:10.1016/j.jhin.2023.03.026

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…By further dividing the samples according to their collection time, we found no statistical differences among the 1 ~ 7 d.p.o, 8 ~ 14 d.p.o and 15 ~ 21 d.p.o groups (Table S3 ). Previous studies have successfully recovered viable MPXV from environmental fomite swabs with the lowest viral load of 6.59 log 10 copies per mL (3.9 × 10 6 copies per mL) 31 , 32 , indicating a high risk of transmission when the viral load was higher than that. Therefore, we then further analyzed the distribution of viral loads from these environmental fomites.…”

Section: Resultsmentioning

confidence: 99%

Longitudinal viral shedding and antibody response characteristics of men with acute infection of monkeypox virus: a prospective cohort study

Yang,

Niu,

Shen

et al. 2024

Nat Commun

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Understanding of infection dynamics is important for public health measures against monkeypox virus (MPXV) infection. Herein, samples from multiple body sites and environmental fomites of 77 acute MPXV infections (HIV co-infection: N = 42) were collected every two to three days and used for detection of MPXV DNA, surface protein specific antibodies and neutralizing titers. Skin lesions show 100% positivity rate of MPXV DNA, followed by rectum (88.16%), saliva (83.78%) and oropharynx (78.95%). Positivity rate of oropharynx decreases rapidly after 7 days post symptom onset (d.p.o), while the rectum and saliva maintain a positivity rate similar to skin lesions. Viral dynamics are similar among skin lesions, saliva and oropharynx, with a peak at about 6 d.p.o. In contrast, viral levels in the rectum peak at the beginning of symptom onset and decrease rapidly thereafter. 52.66% of environmental fomite swabs are positive for MPXV DNA, with highest positivity rate (69.89%) from air-conditioning air outlets. High seropositivity against A29L (100%) and H3L (94.74%) are detected, while a correlation between IgG endpoint titers and neutralizing titers is only found for A29L. Most indexes are similar between HIV and Non-HIV participants, while HIV and rectitis are associated with higher viral loads in rectum.

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Section: Resultsmentioning

confidence: 99%

Longitudinal viral shedding and antibody response characteristics of men with acute infection of monkeypox virus: a prospective cohort study

Yang,

Niu,

Shen

et al. 2024

Nat Commun

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“…Mpox can be transmitted via direct contact with infected body fluids, sexual contacts, lesion material from humans or animals, or indirect contact with contaminated material ( 3 , 4 ). Human-to-human transmission occurs primarily through large respiratory droplets ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Current knowledge of human Mpox viral infection among healthcare workers in Cameroon calls for capacity-strengthening for pandemic preparedness

Nka,

Bouba,

Fokam

et al. 2024

Front. Public Health

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IntroductionAn increased incidence of human Monkeypox (Mpox) cases was recently observed worldwide, including in Cameroon. To ensure efficient preparedness and interventions in the health system, we sought to assess the knowledge of Mpox's transmission, prevention, and response among healthcare workers (HCWs) in Cameroon.MethodsA cross-sectional online survey was conducted among HCWs in Cameroon using 21-item questions adapted from the United States Centers for Disease Control and Prevention (US-CDC) standard questionnaire on Mpox. The overall knowledge of Mpox was assessed by cumulative score and categorized as excellent (≥80%, 17/21) or good (≥70%, ≥15/21) knowledge. The regression analysis was used to identify the predictors of Mpox knowledge.ResultsThe survey enrolled 377 participants, but only responses from 342 participants were analyzed. Overall, 50.6% were female participants, and 59.6% aged 30 years or younger. The majority of the participants were medical doctors (50.3%); most worked in central-level hospitals (25.1%) and had 1–5 years of experience (70.7%). A total of up to 92.7% were aware of Mpox, with social media (58.7%) and radio/television (49.2%) as the main sources. The mean knowledge score was 14.0 ± 3.0 (4 to 20), with only 12.9% having excellent knowledge (≥80%) and 42.1% having good knowledge of Mpox. Younger age (26–30 years old) was associated with good knowledge, while workplace type was associated with excellent knowledge of Mpox (aOR [95% CI]: 4.01 [1.43–11.24]). Knowledge of treatment/management of Mpox was generally poor across the different professional categories.ConclusionKnowledge of Mpox among HCWs is substandard across different professionals. Thus, for optimal preparedness and immediate interventions for Mpox and similar emerging pathogens, capacity-strengthening programs should be organized for HCWs while encouraging scientific literature and organizational social media websites.

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Wastewater analysis of Mpox virus in a city with low prevalence of Mpox disease: an environmental surveillance study

Oghuan,

Chavarria,

Vanderwal

et al. 2023

The Lancet Regional Health - Americas

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Persistence of infectious mpox virus on the surfaces of isolation ward in a hospital setting, India

Cited by 3 publications

References 5 publications

Longitudinal viral shedding and antibody response characteristics of men with acute infection of monkeypox virus: a prospective cohort study

Longitudinal viral shedding and antibody response characteristics of men with acute infection of monkeypox virus: a prospective cohort study

Current knowledge of human Mpox viral infection among healthcare workers in Cameroon calls for capacity-strengthening for pandemic preparedness

Wastewater analysis of Mpox virus in a city with low prevalence of Mpox disease: an environmental surveillance study

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