Persistence of intestinal SARS-CoV-2 infection in patients with COVID-19 leads to re-admission after pneumonia resolved

Wang, Xiaorong; Zhou, Yaya; Jiang, Nanchuan; Zhou, Qiong; Ma, Wanli

doi:10.1016/j.ijid.2020.04.063

Cited by 61 publications

(60 citation statements)

References 6 publications

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“…A recent study showed that the rectal swabs of 8 pediatric COVID-19 patients persistently tested positive after nasopharyngeal testing was negative, suggesting that the viral shedding from the GI tract might last longer than that from the respiratory tract [ 41 ]. In other cases, 3 COVID-19 patients with GI symptoms were re-admitted after pneumonia had resolved due to the persistence of intestinal SARS-CoV-2 infection [ 42 ]. Thus, our findings are in line with these clinical observations supporting the persistence of SARS-CoV-2 infection in the GI tract.…”

Section: Discussionmentioning

confidence: 99%

Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells

Lee

Yoon

Myoung

et al. 2020

Emerging Microbes & Infections

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Studies on patients with the coronavirus disease-2019 (COVID-19) have implicated that the gastrointestinal (GI) tract is a major site of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We established a human GI tract cell line model highly permissive to SARS-CoV-2. These cells, C2BBe1 intestinal cells with a brush border having high levels of transmembrane serine protease 2 (TMPRSS2), showed robust viral propagation, and could be persistently infected with SARS-CoV-2, supporting the clinical observations of persistent GI infection in COVID-19 patients. Ectopic expression of viral receptors revealed that the levels of angiotensin-converting enzyme 2 (ACE2) expression confer permissiveness to SARS-CoV-2 infection, and TMPRSS2 greatly facilitates ACE2-mediated SARS-CoV-2 dissemination. Interestingly, ACE2 but not TMPRSS2 expression was significantly promoted by enterocytic differentiation, suggesting that the state of enterocytic differentiation may serve as a determining factor for viral propagation. Thus, our study sheds light on the pathogenesis of SARS-CoV-2 in the GI tract.

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Section: Discussionmentioning

confidence: 99%

Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells

Lee

Yoon

Myoung

et al. 2020

Emerging Microbes & Infections

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“…In addition, Coronavirus can cause liver disorders and neurological symptoms, because those are the part of Coronaviridae family (33). Most of Covid19 positive sufferers got fever or respiratory problems (33)(34)(35)(36). Other symptoms and indication of Covid19 sufferers are cough, diarrhea, myalgia or fatigue, and headaches (35)(36).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Ambient Air Pollution Toward Coronavirus Disease 2019 (Covid19): A Literature Review

Nasikhah

Pawitra

2020

JKL

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Introduction: WHO has announced coronavirus Disease 2019 (Covid19) as a global pandemic at the immune decline, one of which is due to chronic exposure to ambient air pollution. This literature review aims to describe the impact of ambient air pollution toward the risk of being infected by Covid19. Discussion: Covid19 can be found in a bat (host primer), and can be contagious through a person, also possible from pets. The symptoms that sufferers will perceive are fever, cough, diarrhea, myalgia, fatigue, headache, nausea, vomit, abdominal pain, loss of appetite, and some asymptomatic people. The body’s immunity affects a person’s susceptibility to Covid19 infection. The body’s immunity can be affected by ambient air pollution (with PM10, PM2,5, and O3 are the most pollutant in the air in various countries) for an extended period could be the reason for chronic illness (especially, respiratory tract) could reduce immune resistance. Furthermore, it might be happened on increasing at ACE2 activity and can cause increasing infected by Covid19. Prevention action can be done by contributing from all of the sectors at an observance in guarding, physical distancing, quarantine, and maintaining the ambient air quality in the future. Conclusion: Ambient air pollution must be considered as one effort to prevent chronic illness that can reduce immunity, which can increase the risk of being infected with Covid19. Furthermore, future studies will be carried out on ACE2 activity in people infected with Covid19 in order to get more valid results and following current conditions.

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“…It has been reported that the persistence of intestinal SARS-CoV-2 shedding in some patients has led to their re-admission after their pneumonia had resolved [4]. Antiviral therapies appear to be an important means to resolve the problem of viral persistence.…”

Section: Dear Editormentioning

confidence: 99%

Oral favipiravir for patients with delayed SARS-CoV-2 viral RNA clearance: a case series

Cao²,

Zhao³

et al. 2020

Crit Care

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Persistence of intestinal SARS-CoV-2 infection in patients with COVID-19 leads to re-admission after pneumonia resolved

Abstract: The current reports of COVID-19 focus on the respiratory system, however, intestinal infections caused by SARS-CoV-2 are also worthy of attention. This paper reported persistence of intestinal SARS-CoV-2 infection leads to re-admission after pneumonia resolved in three cases with COVID-19.

Cited by 61 publications

References 6 publications

Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells

Robust and persistent SARS-CoV-2 infection in the human intestinal brush border expressing cells

The Impact of Ambient Air Pollution Toward Coronavirus Disease 2019 (Covid19): A Literature Review

Oral favipiravir for patients with delayed SARS-CoV-2 viral RNA clearance: a case series

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