Persistence of Low Serum C3 Level is Associated with Higher Relapse Rate and Influences Prognosis in Lupus Nephritis

Wang, S.Y.; Zhang, Y.; Xü, Ying; Chen, J.H.

doi:10.1016/j.hkjn.2015.08.148

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Decreased serum C3 levels, frequently observed in LN, are associated with complement over-activation and seem to determine a worse renal prognosis [123]. In a retrospective study of 39 patients with active LN, the prevalence of low C3 plasma concentration was related to a higher relapse rate and the progression of renal disease [124]. Of note, a positive correlation between low C3 and clinically silent, but morphologically active juvenile LN has been reported [120].…”

Section: Lupus Nephritismentioning

confidence: 98%

The role of the alternative pathway of complement activation in glomerular diseases

2018

View full text Add to dashboard Cite

The complement system (CS) has recently been recognized as a bridge between innate and adaptive immunity that constitutes a very complex mechanism controlling the clearance of pathogens, cellular debris, and immune complexes. Out of three known pathways of complement activation, the alternative pathway (AP) plays a critical role in host defense by amplifying the complement response, independently of initiation pathway and continuously maintaining low-level activity in a process called 'thick-over.' A key molecule of the CS is C3, in which the AP is constantly activated. To prevent host cell destruction, a group of the AP regulators tightly controls this pathway of the CS activation. Acquired and genetic abnormalities of the CS may alter the delicate balance between enhancing and inhibiting the AP cascade. These can lead to the uncontrolled CS activation, inflammatory response, and subsequent tissue damage. Since complement components are locally produced and activated in the kidney, the abnormalities targeting the AP may cause glomerular injury. C3 glomerulopathy is a new entity, in which the AP dysregulation has been well established. However, recent studies indicate that the AP may also contribute to a wide range of kidney pathologies, including immune-complex-mediated glomerulonephritis (GN), pauci-immune GN, and primary membranous nephropathy (PMN). This article provides insight into current knowledge on the role of the AP in the pathogenesis of glomerular diseases, focusing mainly on various types of primary and secondary GN and PMN.

show abstract

Section: Lupus Nephritismentioning

confidence: 98%