Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis

Fernandez-de-las-Peñas, Cesar; Notarte, Kin Israel; Macasaet, Raymart; Velasco, Jacqueline Veronica; Catahay, Jesus Alfonso; Ver, Abbygail Therese; Chung, William; Valera-Calero, Juan A.; Navarro-Santana, Marcos

doi:10.1016/j.jinf.2023.12.004

Cited by 54 publications

(8 citation statements)

References 37 publications

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“…Several studies on post-COVID-19 conditions have yielded diverse findings, influenced by time since infection, acute disease severity, geographic region, and sociodemographic characteristics, such as age and sex [7][8][9][10]. Mukherjee et al conducted a meta-analysis that revealed a higher prevalence of post-COVID-19 conditions in hospitalized patients (0.54) compared to non-hospitalized patients (0.34), with females exhibiting a slightly higher prevalence (0.49) than males (0.37).…”

Section: Discussionmentioning

confidence: 99%

“…Post-COVID-19 conditions is distinguished by its prolonged duration and diverse array of symptoms compared to other respiratory illnesses, such as influenza infection, despite exhibiting a similar prevalence of symptoms compared to other respiratory virus infections [3][4][5][6]. Fatigue and neuropsychiatric manifestations, such as sleep disturbances, anxiety, and depression, are the most frequently reported symptoms [7][8][9][10]; these symptoms significantly impair patient quality of life and ability to return to work [11][12][13][14][15][16]. Working individuals are particularly susceptible to long-term effects [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Prevalences and Interrelationships of Post COVID-19 Fatigue, Sleep Disturbances, and Depression in Healthy Young and Middle-Aged Adults

Kim,

Moon,

Kim

et al. 2024

JCM

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Background: An evaluation of the persistence of symptoms following COVID-19 in economically active young and middle-aged adults is crucial due to its significant socioeconomic impact resulting from compromised work performance. Methods: A prospective, multicenter study at 12 South Korean hospitals from January to December 2022 involved telephone interviews along with validated questionnaires. Results: Among 696 participants with a median age of 32 and no prior diagnoses, 30% of participants experienced persistent fatigue, while 21.4% suffered from sleep disturbance at 6 months following infection. Additionally, approximately 25% of the participants exhibited depression that endured for up to 6 months. Symptomatic individuals at 3 months exhibited a significantly higher prevalence of persistent fatigue, sleep disturbances, and depression at 6 months compared to those who remained asymptomatic. Notably, sleep disturbance and persistent fatigue at 3 months emerged as significant independent predictors of the presence of depression at 6 months. Conclusions: Even among young and middle-aged healthy adults, prolonged fatigue, sleep disturbance, and depression exhibit a significant prevalence and persisted for up to 6 months. Therefore, implementing a workplace management protocol for these symptoms is essential to mitigate the socioeconomic burden caused by the impairment of work efficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalences and Interrelationships of Post COVID-19 Fatigue, Sleep Disturbances, and Depression in Healthy Young and Middle-Aged Adults

Kim,

Moon,

Kim

et al. 2024

JCM

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“…Additionally, International Journal of Women's Health 2024:16 865-876 recent evidence highlights the effectiveness of vaccination in potentially lowering the risk of developing long COVID, 6 the most dreaded sequelae of acute infection, which can persist for up to two years. 7 COVID-19 vaccination is an important strategy to mitigate the risks of complications for both mothers and fetuses. Recognizing its significance, the American College of Obstetricians and Gynecologists (ACOG), the Society for Maternal-Fetal Medicine (SMFM), and the Centers for Disease Control and Prevention (CDC) strongly recommend COVID-19 vaccination during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, recent evidence highlights the effectiveness of vaccination in potentially lowering the risk of developing long COVID, 6 the most dreaded sequelae of acute infection, which can persist for up to two years. 7 …”

Section: Introductionmentioning

confidence: 99%

COVID-19 Vaccine Acceptance of Pregnant Women in Thailand

Nirunrungraung,

Lattiwongsakorn,

Piyamongkol

2024

IJWH

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The data was collected using face-to-face questionnaires comprising 29 closed-end questions. Pregnant women aged 18 years old or over visiting the antenatal care clinic were included. Results:The study included 200 participants, revealing a COVID-19 vaccine acceptance rate of 17%. Healthcare provider recommendations significantly increased vaccine acceptance by nearly two-fold (30.77%, p-value < 0.01). The major cause of vaccine hesitancy was the concern about vaccine safety that potentially harmed their babies (77.44%). Conclusion:The COVID-19 vaccine acceptance rate among pregnant women in Thailand was low. Healthcare provider recommendations played a pivotal role in positively impacting vaccine acceptance, highlighting their importance in increasing acceptance rates in the future. Plain Language Summary:This study investigated the COVID-19 vaccine acceptance rate among pregnant women in Thailand and explored factors influencing their willingness to receive the vaccine. The study included 200 participants, revealing a COVID-19 vaccine acceptance rate of 17%. Healthcare provider recommendations significantly increased vaccine acceptance by nearly two-fold (30.77%, p-value < 0.01). The major cause of vaccine hesitancy was the concern about vaccine safety that potentially harming their babies (77.44%). The COVID-19 vaccine acceptance rate among pregnant women in Thailand was low. Healthcare provider recommendations played a pivotal role in positively impacting vaccine acceptance, highlighting their importance in increasing acceptance rates in the future.

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“…In fact, more than 100 symptoms affecting the cardiovascular, neurological, immune, respiratory, musculoskeletal, and gastrointestinal systems have been attributed to SARS-CoV-2 since the beginning of the pandemic [ 14 ]. With increasing evidence growing each week, and after three years of pandemic, recent meta-analyses have reported the presence of post-COVID symptoms one [ 15 , 16 ] or two [ 17 ] years after an acute SARS-CoV-2 infection in almost 25–30% of patients. Thus, the Global Burden of Disease Long COVID study (which included 1.2 million of subjects who had experienced an acute symptomatic SARS-CoV-2 infection) reported that 15% of COVID-19 survivors exhibit at least one post-COVID symptom one year after infection [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors

Fernández-de-las-Peñas,

Díaz-Gil,

Gil-Crujera

et al. 2024

Viruses

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The aim of this study was to identify the association between four selected inflammatory polymorphisms with the development of long-term post-COVID symptoms in subjects who had been hospitalized due to SARS-CoV-2 infection during the first wave of the pandemic. These polymorphisms were selected as they are associated with severe COVID-19 disease and cytokine storm, so they could be important to prognoses post-COVID. A total of 408 (48.5% female, age: 58.5 ± 14.0 years) previously hospitalized COVID-19 survivors participated. The three potential genotypes of the following four single-nucleotide polymorphisms, IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252, were obtained from non-stimulated saliva samples of the participants. The participants were asked to self-report the presence of any post-COVID symptoms (defined as symptoms that had started no later than one month after SARS-CoV-2 acute infection) and whether the symptoms persisted at the time of the study. At the time of the study (mean: 15.6, SD: 5.6 months after discharge), 89.4% of patients reported at least one post-COVID symptom (mean number of symptoms: 3.0; SD: 1.7). Fatigue (69.3%), pain (40.9%), and memory loss (27.2%) were the most prevalent post-COVID symptoms in the total sample. Overall, no differences in the post-COVID symptoms depending on the IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252 genotypes were seen. The four SNPs assessed, albeit having been previously associated with inflammation and COVID-19 severity, did not cause a predisposition to the development of post-COVID symptoms in the previously hospitalized COVID-19 survivors.

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Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis

Cited by 54 publications

References 37 publications

Prevalences and Interrelationships of Post COVID-19 Fatigue, Sleep Disturbances, and Depression in Healthy Young and Middle-Aged Adults

Prevalences and Interrelationships of Post COVID-19 Fatigue, Sleep Disturbances, and Depression in Healthy Young and Middle-Aged Adults

COVID-19 Vaccine Acceptance of Pregnant Women in Thailand

Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors

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