Persistence of Schistosoma haematobium Infection Despite Multiple Courses of Therapy with Praziquantel

Herwaldt, Barbara L.; Tao, Liang-Feng; Pelt, Wilfrid van; Tsang, Victor C. W.; Bruce, J. I.

doi:10.1093/clinids/20.2.309

Cited by 37 publications

(23 citation statements)

References 29 publications

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“…Of the 89 reviewed documents, 22 (25%) reported on individuals who had developed signs and symptoms of schistosomiasis after returning from a visit to Malawi. These documents comprised 13 case reports and 9 letters to the editor written by non-Malawian authors [25,30,[33][34][35][36][37][38][39][40][46][47][48][49][50][51][52][53][54][55][56][89][90][91]94,95,97,107].…”

Section: Schistosomiasis and Tourism In Malawimentioning

confidence: 99%

Schistosomiasis in Malawi: a systematic review

Makaula¹,

Sadalaki

Muula

et al. 2014

Parasites & Vectors

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Introduction: Schistosomiasis remains an important public health problem that undermines social and economic development in tropical regions of the world, mainly Sub-Saharan Africa. We are not aware of any systematic review of the literature of the epidemiology and transmission of schistosomiasis in Malawi since 1985. Therefore, we reviewed the current state of knowledge of schistosomiasis epidemiology and transmission in this country and identified knowledge gaps and relevant areas for future research and research governance. Methods: We conducted computer-aided literature searches of Medline, SCOPUS and Google Scholar using the keywords: "schistosomiasis", "Bilharzia", "Bulinus" and "Biomphalaria" in combination with "Malawi". These searches were supplemented by iterative reviews of reference lists for relevant publications in peer reviewed international scientific journals or other media. The recovered documents were reviewed for their year of publication, location of field or laboratory work, authorship characteristics, ethics review, funding sources as well as their findings regarding parasite and intermediate host species, environmental aspects, geographical distribution, seasonality of transmission, and infection prevalence and intensities.

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Section: Schistosomiasis and Tourism In Malawimentioning

confidence: 99%

Schistosomiasis in Malawi: a systematic review

Makaula¹,

Sadalaki

Muula

et al. 2014

Parasites & Vectors

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“…Although praziquantel is the drug of choice for the treatment of S. haematobium infections (Gentilini et al 1982, McMahon 1983, Pugh & Teesdale 1984, Stephenson et al 1989, McNeeley et al 1990, King et al 1992, King & Mahmoud 1999, King et al 2002, cases of treatment failure have been frequently reported, probably due to a progressive increase in the resistance of the parasite to the drug, as observed by some authors (Groning et al 1985, Herwaldt et al 1995, Hatz et al 1998, Ernould et al 1999, Liang et al 2000. Despite the controversies regarding the rapid emergence of praziquantel resistance, constant surveillance of this progression is important.…”

Section: Discussionmentioning

confidence: 99%

“…These important factors have contributed to the tolerance with and easy application of individualized and mass treatments (Stephenson et al 1989, King et al 1992. Nevertheless, failure of praziquantel treatment of various proportions has been reported (Herwaldt et al 1995, Liang et al 2000. So, it is necessary to be sure about the + Corresponding author.…”

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confidence: 99%

Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa

Silva

Thiengo²,

Conceição

et al. 2005

Mem. Inst. Oswaldo Cruz

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Schistosoma haematobium is present in about 53 African countries and in the Middle East, with the helminth showing high endemicity in these regions (CEGET-CNRSAtlas-WHO/1987, home page-WHO). Urinary schistosomiasis is an infectious disease of marked epidemiological importance for both natives and tourists exposed to the helminth in endemic regions.Treatment of urinary schistosomiasis has shown great advances with the introduction of praziquantel into the therapeutic arsenal (Bormann et al. 2001, De Clerq et al. 2002. Advantages of this drug include its easy administration (40 mg/kg body weight, a single dose by the oral route), low toxicity, and low intensity of side effects (McMahon 1983, Pugh & Teesdale 1983, Kahama et al. 1999, Rey 2001. These important factors have contributed to the tolerance with and easy application of individualized and mass treatments (Stephenson et al. 1989, King et al. 1992. Nevertheless, failure of praziquantel treatment of various proportions has been reported (Herwaldt et al. 1995, Liang et al. 2000. So, it is necessary to be sure about the + Corresponding author. E-mail: silva.iran@ig.com.br PATIENTS AND METHODSThree 24-h urine samples were collected from 26 patients at minimum intervals of one week. The patients were Brazilian military men who were part of the United Nation peace mission in Mozambique in 1994, age between 26 and 55 years old, median age of 29 years. The principal condition was the report of exposure in Licungo river and signals and symptoms affecting the genitourinary tract after exposure.Helminth eggs were recovered by spontaneous sedimentation and subsequent centrifugation of the urine sample. The total urine volume was transferred to glass chalices and left to stand for 24 h. After this period, 10 ml of the initial sediment was removed with a glass pipette held close to the bottom of the chalice and centrifuged at 3500 r.p.m. for 5 min. One-hundred microliters of the centrifuged material was removed with a glass pipette held close to the bottom of the tube, mounted on a slide, coverslipped, and observed under a microscope at magnifications of 100× and 400×. For endoscopic examination, an Olympus model 19 CH cystoscope with a 30 o eyepiece was used. 446 446 446 446 Schistosoma haematobium in Brazilians • • • • • Iran Mendonça da Silva et al.After the positive diagnosis, the patients were treated with 40 mg/kg body weight praziquantel administered in a single dose. Three other 24-h urine exams were repeated at 7-day intervals by the same technique, after a minimum period of 21 days after treatment. Treatment was repeated under medical supervision to ensure the correct use of the drug. In the case of suspicion of lesions, all individuals were submitted to cystoscopy followed by biopsy and histopathological examination at 6-month intervals, after each treatment or retreatment, under the same conditions as used for the initial diagnosis. The urine examination, with the same technique, was repeated after each cistoscopy.In the case of evidence of vesical involveme...

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“…However, the mechanism of action of PZQ is still unidentified although data shown it causes schistosomes to develop tetanic contractions and tegumental vacuoles; affected worms lose their hold on the vein wall, and then washed upstream to the liver and die [6][7][8]. Several PZQ-resistant isolates already have identified [9,10]. There have been several studies to modify PZQ, but have yet to reach clinical trials [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and SAR Studies of New Oxadiazole-2-oxide Derivatives with Remarkable In Vitro Activity against Schistosoma japonicum

M¹,

F²,

S³

et al. 2017

J Microb Biochem Technol

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Persistence of Schistosoma haematobium Infection Despite Multiple Courses of Therapy with Praziquantel

Cited by 37 publications

References 29 publications

Schistosomiasis in Malawi: a systematic review

Schistosomiasis in Malawi: a systematic review

Therapeutic failure of praziquantel in the treatment of Schistosoma haematobium infection in Brazilians returning from Africa

Synthesis and SAR Studies of New Oxadiazole-2-oxide Derivatives with Remarkable In Vitro Activity against Schistosoma japonicum

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