Persistence of serum lipid abnormalities in children with idiopathic nephrotic syndrome

Zilleruelo, Gastón; Hsia, S.L.; Freundlich, Michael; Gorman, Helen M.; Strauss, José

doi:10.1016/s0022-3476(84)80590-9

Cited by 60 publications

(36 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This suggests that steroids will neither suppress the oxidative stress nor correct the lipid abnormalities in NS [23] and some other modality of treatment is required to prevent formation of oxidized lipids. The results of study done by researchers suggest that nephrotic children may have prolonged periods of hyperlipidaemia even after clinical remission [31]. The abnormal lipid profile is more likely seen in children with frequent relapses even during their remission [32].…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase Activity and Lipid Profile in Paediatric Nephrotic Syndrome: A Cross-sectional Study

Patil

et al. 2016

JCDR

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Paraoxonase Activity and Lipid Profile in Paediatric Nephrotic Syndrome: A Cross-sectional Study

Patil

et al. 2016

JCDR

View full text Add to dashboard Cite

“…[1] Cases with increased serum levels of cholesterol and LDL have also been reported even after months or years in remission. [2] The persistent hyperlipidemia correlates well with the duration and frequency of the relapses, even during the remission. Further, the intensity of hyperlipidemia is also related to the severity of proteinuria and hypoalbuminemia.…”

Section: Introductionmentioning

confidence: 95%

Plasma Lipid Profile - Prognostic Factor in Nephrotic Syndrome – A Prospective Study

Subasakthi¹,

Suresh²,

Prasath³

et al. 2017

Ann. Int. Med. Den.Res.

View full text Add to dashboard Cite

Background: Nephrotic Syndrome is one of the most common glomerular disorders of childhood. Relapse rate after steroid discontinuation is 39-59%. Hyperlipidemia is one of the cardinal features in patients with Nephrotic Syndrome. Cases with increased serum levels of cholesterol and LDL have also been reported even after months or years in remission. The persistent hyperlipidemia correlates well with the duration and frequency of the relapses, even during the remission. Aim: To study the correlation between remission phase hyperlipidemia and subsequent relapse in Nephrotic Syndrome. Methods: Sixty five children were included in this cohort study at Kanyakumari Medical College & Hospital, Asaripallam. Fasting lipid profile is estimated at the acute phase of Nephrotic Syndrome before starting steroid therapy and 10 weeks after remission. They were followed up for six months from the time of remission to determine the occurrence of relapse. Results: Among the 60 included patients, 22 cases had their first episodes and 38 were infrequent relapse. Persistent hypercholesterolemia was observed in ten cases, out of which, seven cases developed relapse. Also, persistent hypertriglyceridemia was seen in 34 cases, out of which, 19 cases developed relapse. However, in the remission phase, hypercholesterolemia (chi sq= 5.090, p=0.024) and hypertriglyceridemia (chi sq= 10.22, p=0.001) were significantly associated with relapse. Conclusion: The role of dietary management and anti-triglyceridemic drugs to prevent progressive renal injury and subsequent relapse in this subgroup of patients' needs to be evaluated.

show abstract

“…Zilleruelo et al [25] studied 51 children with minimal change nephrotic syndrome and demon strated persistently raised plasma cholesterol, triglycer ide, LDL and VLDL concentrations in 24 patients in remission. Patients with longer and more frequent re lapses demonstrated higher plasma total cholesterol con centrations.…”

Section: Lipid and Lipoprotein Abnormalities In Human Nephroticsmentioning

confidence: 99%

Hyperlipidemia in Nephrotic Syndrome

Wheeler

Varghese

Moorhead³

1989

Am J Nephrol

View full text Add to dashboard Cite

Persistence of serum lipid abnormalities in children with idiopathic nephrotic syndrome

Cited by 60 publications

References 14 publications

Paraoxonase Activity and Lipid Profile in Paediatric Nephrotic Syndrome: A Cross-sectional Study

Paraoxonase Activity and Lipid Profile in Paediatric Nephrotic Syndrome: A Cross-sectional Study

Plasma Lipid Profile - Prognostic Factor in Nephrotic Syndrome – A Prospective Study

Hyperlipidemia in Nephrotic Syndrome

Contact Info

Product

Resources

About