Persistence of sleep disturbance among post‐COVID patients: Findings from a 2‐month follow‐up study in a Bangladeshi cohort

Abstract

To evaluate the persistence and factors associated with sleep disturbances among COVID-19 patients with a history of sleep disturbances 2 months after discharge from the hospital. A total of 400 patients admitted at Dhaka Medical College Hospital during July and August were diagnosed as suffering from sleep disturbances during their hospital stay using a standardized scale. They were followed up 2 months later through telephone, and a total of 322 participants were interviewed (excluding 63 nonresponders and five deceased) regarding the persistence of disturbances in sleep through a structured questionnaire. Patient demographic, clinical, and epidemiological data including history regarding in-hospital sleep disturbance were retrieved from hospital treatment sheets. Results revealed, 35% of study participants (n = 113) were still experiencing symptoms of sleep disturbances during the interview by telephone. Age (p = 0.015), diabetes mellitus (relative risk [RR]: 1.21; confidence interval [CI]: 1.02-1.42, p = 0.022), on admission SPO 2 (p = 0.009), C-reactive protein (CRP) (p = 0.025), serum ferritin (p = 0.014), and D-dimer(p = 0.030) were independently associated with sleep disturbances among participants (p < 0.05). Binary and fitting logistic regression through repeated K folds crossvalidation revealed 1.65 (CI: 1.02-2.66), 1.07 (CI: 1.01-1.14), and 1.07 (CI: 1.00-1.15) times higher odds of persistence of sleep disturbances among patients with diabetes mellitus, increased neutrophil, and lymphocyte percentages, respectively. Findings of this study need to be validated and patients should be further followed up with more in-depth studies conducted 6 or 12 months after initial infection, possibly with the help of higher sample size and in-person interview.

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A phenome‐wide investigation of risk factors for severe COVID‐19

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Causal associations of tea intake with COVID-19 infection and severity

“…A collection of risk and protective factors have been identified to be associated with COVID-19 (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Meanwhile, COVID-19 can give rise to a myriad of post-COVID-19 consequences (11)(12)(13)(14)(15). The continued effectiveness of the current generation of COVID-19 vaccines and the possible acquisition of resistance to antivirals remain a concern.…”