Persistence of the Circadian Rhythm of REM Sleep: A Variety of Experimental Manipulations of the Sleep-Wake Cycle

Endo, Shiro; Kobayashi, Toshinori; Yamamoto, Takuji; Fukuda, Hideki; Sasaki, Mitsuo; Ohta, Tatsuro

doi:10.1093/sleep/4.3.319

Cited by 57 publications

(30 citation statements)

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“…Sleep characterized by autonomic nervous activity was in line with the findings of prior studies, which revealed a sympathetic dominance in the autonomic system during REM sleep and the major influence of vagal activity during NREM sleep 23,24) . In addition, if the LF/HF was higher in NREM sleep, this phenomenon was associated with more-frequent interruptions during sleep 25) .…”

Section: Discussionsupporting

confidence: 89%

Recovery after Three-shift Work: Relation to Sleep-related Cardiac Neuronal Regulation in Nurses

Chung

Kuo²,

Hsu

et al. 2012

Ind Health

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This study was to evaluate whether sleep-related autonomic function in nurses recovers during their days off following a rapidly rotating, clockwise shift schedule. Ten rotating-shift nurses and ten regular morning-shift nurses were included. Nurses slept at home and were allowed to sleep and wake spontaneously. For the rotating-shift workers, ambulatory polysomnographic recordings were taken during nighttime sleep (after the second morning shift, afternoon shift, and on days off) and during daytime sleep (after the second night shift). No significant differences were found between regular-shift nurses and rotating-shift nurses in terms of sleep patterns and cardiac autonomic functions during day shift. When comparing sleep patterns within shift groups, the total sleep time of night shift was lower than their other shifts. Controlling for the variable of total sleep time allowed us to compare cardiac autonomic functions following different shifts (for the rotating shift nurses). During the non-rapid eye movement and rapid eye movement periods, the high frequency (HF) value on rotating shift nurses' days off was found to be significantly higher than their other shifts. However, the low to high frequency ratio (LF/HF) on days off was found to be obviously lower than that during shift work. Two consecutive days off may be sufficient for nurses to recover sleep-related autonomic functions after a rapidly rotating, clockwise three-shift schedule. Sleeprelated autonomic functions may be improved during days off to minimize health risks.

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Section: Discussionsupporting

confidence: 89%

Recovery after Three-shift Work: Relation to Sleep-related Cardiac Neuronal Regulation in Nurses

Chung

Kuo²,

Hsu

et al. 2012

Ind Health

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“…Sleep characterized by autonomic nervous activity was found to be in line with the findings of prior studies (30,31), which revealed a sympathetic dominance in the autonomic system during REM sleep. However, this result contradicted the expectation that vagal influence would be predominant during NREM sleep.…”

Section: Figure1 Electroencephalographic Delta-power During Periods supporting

confidence: 89%

Sleep and autonomic nervous system changes – enhanced cardiac sympathetic modulations during sleep in permanent night shift nurses

Chung¹,

Kuo²,

Hsu³

et al. 2009

Scand J Work Environ Health

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“…It therefore probably will not depend strongly on the state of the ultradian oscillator, but, most likely, on circadian and homeostatic mechanisms. Such processes certainly influence the process of REMS production, since a clear correlation exists between the amount of REMS and the circadian phase of the body temperature rhythm (22)(23)(24)(25). There are experimental conditions in which sleep is shifted to an abnormal phase of the temperature cycle, leading to the occurrence of short REM latencies in healthy subjects.…”

Section: Commentsmentioning

confidence: 99%

“…There are experimental conditions in which sleep is shifted to an abnormal phase of the temperature cycle, leading to the occurrence of short REM latencies in healthy subjects. Such observations (23)(24)(25) are of great interest to the present study, but they can only be dealt with after incorporation of circadian and homeostatic influences into the ultradian model system.…”

Section: Commentsmentioning

confidence: 99%

Distribution of REM Latencies and Other Sleep Phenomena in Depression as Explained by a Single Ultradian Rhythm Disturbance

Beersma¹,

Daan²,

Hoofdakker

1984

Sleep

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Summary: The McCarley-Hobson model, describing the alternation of NREM and REM sleep in the cat, was applied to human electroencephalographic data. The influence of initial conditions on oscillatory behavior was especially emphasized. It appears that the distribution of REM latency in depression, the abnormal accumulation of REM sleep, the variability of NREM-REM cycle duration, the frequent stage shifts, and frequent aWakenings can be explained in this model by means of a decrease in the initial value of a single variable, which may be regarded as representing the strength of REM inhibition. The observation of slow wave sleep deficiency in depression may well be another reflection of this parameter. Key Words: REM sleep---Depression-Slow wave sleep---Ultradian rhythm.Numerous polygraphic studies have revealed that the sleep profile of endogenously depressed subjects is characterized by a shortened latency of rapid eye movement sleep (REMS), a relative overproduction of REMS in the first third of the sleep period, a reduction of slow wave sleep (SWS, i.e., stage 3 and 4), frequent stage shifts, frequent intermittent awakenings, and a higher incidence of REMs, especially in the first hours of sleep (1). The shorter REM latency, in particular, is considered to represent a specific feature of primary affective disorders (2,3). Vogel et al. (4) suggested that the abnormalities in REMS production in depression are caused by disturbances in an ultradian oscillator that regulates the NREM-REM alternations. The ultradian oscillator was assumed to be of the same nature as the one described for NREM-REM sleep regulation in the cat by McCarley and Hobson (5) and Hobson et a1. (6). In this model the oscillatory capacity is thought to be achieved by the reciprocal interaction of two elements, one excitatory and active during REMS, the other inhibitory and predominantly active during NREMS (Fig. 1). Vogel et al. (4) postulated that three aspects of this NREM-REM oscillator system are disturbed in depression: the strength of self-excitation of the REM-active part, the strength of the inhibition by the NREM-active part, and the power of the NREM-active part at sleep onset. The McCarleyHobson model, however, provides a different interpretation of sleep abnormalities in depres-

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Persistence of the Circadian Rhythm of REM Sleep: A Variety of Experimental Manipulations of the Sleep-Wake Cycle

Cited by 57 publications

References 0 publications

Recovery after Three-shift Work: Relation to Sleep-related Cardiac Neuronal Regulation in Nurses

Recovery after Three-shift Work: Relation to Sleep-related Cardiac Neuronal Regulation in Nurses

Sleep and autonomic nervous system changes – enhanced cardiac sympathetic modulations during sleep in permanent night shift nurses

Distribution of REM Latencies and Other Sleep Phenomena in Depression as Explained by a Single Ultradian Rhythm Disturbance

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