Persistence of the efficacy of a moxidectin gel on the establishment of cyathostominae in horses

Vercruysse, Jozef; Eysker, M.; Demeulenaere, D; Smets, Katelijne; Dorny, Pierre

doi:10.1136/vr.143.11.307

Cited by 12 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of this study demonstrate that moxidectin 2 per cent gel was highly effective against the adult and larval stages of cyathostomes, giving a 90·8 per cent and 99·9 per cent reduction in el3 and developing larvae, respectively, when compared with the controls. Together with its persistent activity profile (Vercruysse and others 1998) and its activity against benzimidazole‐resistant cyathostomes (Collobert and others 1998) this makes moxidectin one of the best preparations available for the treatment of equine cyathostomiasis.…”

Section: Discussionmentioning

confidence: 99%

Efficac of moxidectin 2 per cent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomes

et al. 2001

View full text Add to dashboard Cite

The efficacy of moxidectin 2 per cent equine gel against naturally acquired strongyle infections was assessed in 18 ponies which had grazed on contaminated pasture before being housed for eight weeks. Twenty-four hours before the treatment, two randomly selected ponies were euthanased and their worm burdens were determined. Eight of the remaining 16 ponies were treated with moxidectin 2 per cent gel while the other eight were given a placebo gel. Eight weeks later the 16 animals were necropsied and their worm burdens established. A 100 per cent efficacy was recorded against adult and lumenal L4 cyathostomes and adult Strongylus and Triodontophorus species. Digest recoveries of larval cyathostomes indicated a 90.8 per cent (P<0.002) reduction in early L3 and a 99.9 per cent (P<0.001) reduction in developing stages. There was a reduction in faecal egg output of between 96 and 100 per cent in the treated animals compared with the controls.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficac of moxidectin 2 per cent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomes

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Moxidectin, in addition to having high efficacy against all cyathostomin stages given as a single dose at a rate of 0.4 mg/Kg liveweight [ 62 - 66 ] also provides persistent activity against re-infection by small strongyles [ 67 ], resulting in a long egg re-appearance interval. The required re-treatment interval with moxidectin is longer than that for other anthelmintics allowing less frequent treatment and less selection for resistance [ 44 , 57 , 68 - 75 ].…”

Section: Current Control Measuresmentioning

confidence: 99%

Equine cyathostomins: a review of biology, clinical significance and therapy

Corning¹

2009

Parasites Vectors

136

View full text Add to dashboard Cite

The small strongyles of horses, also known as cyathostomins, are considered the most prevalent and pathogenic parasites of horses today. The clinical syndrome of larval cyathostominosis which occurs as a result of mass emergence of inhibited stages has a high fatality rate despite the best standard of care given to affected horses. Management of the challenge level of cyathostomins to prevent the syndrome is preferable. Many different management programmes have been tried over the past two decades, with mixed success. Programmes have relied heavily on repeated use of anthelmintic treatments throughout the life of a horse.The widespread incidence of resistance to certain anthelmintics is reducing these options.An understanding of the biology of cyathostomins, risk factors for infection and appropriate strategic use of still effective anthelmintics is essential for the future management of this parasite group.This review highlights the necessity to use currently available anthelmintics that are appropriately suited to the biology of cyathostomins, and to maintain heir efficacy through an appropriate treatment strategy.

show abstract

“…Moxidectin's long ERP can probably be accounted for by its larvicidal activity on encysted stages and its prolonged excretion in the faeces, which results from its prolonged plasma bioavailability (Pérez et al 2001). Moxidectin may provide protection against infection by ingested cyathostomin larvae for 2-3 weeks after it is administered (Vercruysse et al 1998). Because of its long ERP moxidectin is labelled to be used at 12 week intervals.…”

Section: Control Of Cyathostominsmentioning

confidence: 99%

A review of the use of moxidectin in horses

Schumacher

Taintor

2008

Equine Veterinary Education

View full text Add to dashboard Cite

Summary Moxidectin has broad‐spectrum anti‐nematodal and anti‐arthropodal activities in the horse but is not effective against tapeworms or flukes. Moxidectin and ivermectin have the same efficacy against internal, adult parasites of horses. Moxidectin, however, is highly effective in eliminating encysted and hypobiotic larval stages of cyathostomins, whereas ivermectin is not. Treatment of horses with moxidectin results in an egg‐reappearance period (ERP) of 15–24 weeks. Because of its long ERP, moxidectin is labelled to be used at 12 week intervals. Moxidectin may provide protection against infection by ingested cyathostomin larvae for 2–3 weeks after it is administered. The larvicidal activity of moxidectin has often been compared to that of fenbendazole administered at either 7.5 or 10 mg/kg bwt for 5 consecutive days. The efficacy of fenbendazole, when administered daily for 5 consecutive days at 7.5 or 10 mg/kg bwt, against all stages of cyathostomins is often less than that of moxidectin because resistance of cyathostomins to benzimidazoles is prevalent worldwide, and the 5 day course of fenbendazole does not overcome this resistance. There are now reports of resistance of ascarids to moxidectin. Overt resistance of cyathostomins and a shortened egg re‐emergence period after treatment with moxidectin have been reported. Rapid removal of manure by natural fauna can significantly reduce larval nematode concentrations and thereby reduce intervals of anthelmintic treatment. Of the macrocyclic lactones, moxidectin has the least deleterious effect on faecal fauna.

show abstract

Persistence of the efficacy of a moxidectin gel on the establishment of cyathostominae in horses

Cited by 12 publications

References 13 publications

Efficac of moxidectin 2 per cent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomes

Efficac of moxidectin 2 per cent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomes

Equine cyathostomins: a review of biology, clinical significance and therapy

A review of the use of moxidectin in horses

Contact Info

Product

Resources

About