Persistence of Type-Specific Human Papillomavirus Infection and Increased Long-term Risk of Cervical Cancer

Chen, Hui‐Chi; Schiffman, Mark; Lin, Chien Ju; Pan, Mei‐Hung; You, San–Lin; Chuang, Li-Chung; Hsieh, Chang‐Yao; Liaw, Kai–Li; Hsing, Ann W.; Chen, Chien-Jen

doi:10.1093/jnci/djr283

Cited by 160 publications

(162 citation statements)

References 28 publications

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“…Similar to our findings, a study of U.S. women in New Mexico showed significantly lower proportions of CIN2þ attributable to HPV16/18 in Hispanics compared with non-Hispanic whites (17). It is important to caution against extrapolating results from studies of CIN2þ to make inferences about HPV types detected in cervical cancer because only about 30% of CIN2þ lesions could progress to invasive cancer and those that are attributable to HPV16/18 have a much higher likelihood of progression compared with lesions due to other high-risk types (4,26,27). A population-based U.S. study using data from state-based cancer registries found that HPV16/18 are attributable to the same proportion (67%) of invasive cervical cancers in non-Hispanic white and non-Hispanic black women (28).…”

Section: Discussionmentioning

confidence: 99%

HPV Type Attribution in High-Grade Cervical Lesions: Assessing the Potential Benefits of Vaccines in a Population-Based Evaluation in the United States

Hariri

Unger

Schafer

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Two currently available vaccines targeting human papillomavirus (HPV) types 16 and 18 could prevent 70% of cervical cancers and 50% of high-grade cervical lesions. Next-generation vaccines against additional types, such as a candidate 9-valent vaccine against HPV6/11/16/ 18/31/33/45/52/58, could further reduce HPV-associated disease burden.Methods: HPV was typed in archived tissues from women ages 21 to 39 years residing in five catchment areas in the United States with cervical intraepithelial neoplasia 2/3 and adenocarcinoma in situ (CIN2þ) using L1 consensus PCR and type-specific hybridization. Type attribution was estimated using weights to account for lesions with multiple types detected.Results: From 2008 to 2011, 5,498 of 6,306 (87.2%) specimens obtained from 8,469 women with CIN2þ had valid typing results; HPV DNA was detected in 97.3%. Overall, 50.1% of lesions were attributable to HPV16/18, ranging from 50.3% to

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Section: Discussionmentioning

confidence: 99%

HPV Type Attribution in High-Grade Cervical Lesions: Assessing the Potential Benefits of Vaccines in a Population-Based Evaluation in the United States

Hariri

Unger

Schafer

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Studies have shown that persistent detection of high-risk HPV among cytologically normal women drastically increases their risk of future CC. [21][22][23] Therefore, HPV prevalence in older women is more indicative of actual CC risk.…”

Section: Discussionmentioning

confidence: 99%

Using HPV prevalence to predict cervical cancer incidence

Sharma

Bruni

Díaz

et al. 2012

Intl Journal of Cancer

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Knowledge of a country's cervical cancer (CC) burden is critical to informing decisions about resource allocation to combat the disease; however, many countries lack cancer registries to provide such data. We developed a prognostic model to estimate CC incidence rates in countries without cancer registries, leveraging information on human papilloma virus (HPV) prevalence, screening, and other country-level factors. We used multivariate linear regression models to identify predictors of CC incidence in 40 countries. We extracted age-specific HPV prevalence (10-year age groups) by country from a meta-analysis in women with normal cytology (N 5 40) and matched to most recent CC incidence rates from Cancer Incidence in Five Continents when available (N 5 36), or Globocan 2008 (N 5 4). We evaluated country-level behavioral, economic, and public health indicators. CC incidence was significantly associated with age-specific HPV prevalence in women aged 35-64 (adjusted R-squared 0.41) (''base model''). Adding geographic region to the base model increased the adjusted R-squared to 0.77, but the further addition of screening was not statistically significant. Similarly, country-level macro-indicators did not improve predictive validity. Age-specific HPV prevalence at older ages was found to be a better predictor of CC incidence than prevalence in women under 35. However, HPV prevalence could not explain the entire CC burden as many factors modify women's risk of progression to cancer. Geographic region seemed to serve as a proxy for these country-level indicators. Our analysis supports the assertion that conducting a population-based HPV survey targeting women over age 35 can be valuable in approximating the CC risk in a given country.

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“…Cervical cancer is the second most prevalent disease worldwide occurrence with new cases every year and approximately 80% of them reported in developing countries (Munoz et al, 2003;Parkin and Bray, 2006;Lin et al, 2008;Chen et al, 2011 and. Such type of cases appears mainly in between the age of 30 and 50.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Papillomavirus in Women from Saudi Arabia

Turki¹,

Sait²,

Anfinan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Human papillomavirus (HPV) infection is the main causes of cervical cancer in women worldwide. The goal of the present study was to determine the prevalence and distribution of HPV genotypes in women from Saudi Arabia. Recently, several HPV detection methods have been developed, each with different sensitivities and specificities. Methods: In this study, total forty cervical samples were subjected to polymerase chain reaction and hybridization to BioFilmChip microarray assessment. Results: Human papillomavirus (HPV) infections were found in 43% of the specimens. The most prevalent genotypes were HPV 16 (30%) HPV 18 (8.0%) followed by type HPV 45, occurring at 5.0%. Conclusion: Our finding showed the HPV infection and prevalence is increasing at alarming rate in women of Saudi Arabia. There was no low risk infection detected in the tested samples. The BioFilmChip microarray detection system is highly accurate and suitable for detection of single and multiple infections, allowing rapid detection with less time-consumption and easier performance as compared with other methods.

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Persistence of Type-Specific Human Papillomavirus Infection and Increased Long-term Risk of Cervical Cancer

Abstract: HPV negativity was associated with a very low long-term risk of cervical cancer. Persistent detection of HPV among cytologically normal women greatly increased risk. Thus, it is useful to perform repeated HPV testing following an initial positive test.

Cited by 160 publications

References 28 publications

HPV Type Attribution in High-Grade Cervical Lesions: Assessing the Potential Benefits of Vaccines in a Population-Based Evaluation in the United States

HPV Type Attribution in High-Grade Cervical Lesions: Assessing the Potential Benefits of Vaccines in a Population-Based Evaluation in the United States

Using HPV prevalence to predict cervical cancer incidence

Prevalence of Human Papillomavirus in Women from Saudi Arabia

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