Persistence of Vaccine-Induced Immune Responses to Rubella: Comparison with Natural Infection

Horstmann, Dorothy M.; Schluederberg, Ann; Emmons, Jean; Evans, B K; Randolph, Martin F.; Andiman, Warren A.

doi:10.1093/clinids/7.supplement_1.s80

Cited by 68 publications

(21 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…O'Shea et al found that 97.9% of RA 27/3 vaccinees were seropositive 10 to 21 years after immunization (14). Horstmann and colleagues reported that the RA 27/3 vaccine provided high immunogenicity and resulted in high antibody titers; after 11 years, 95% of subjects who seroconverted were tested for hemagglutination inhibition (HI), and 100% had neutralizing antibodies (8). In this study, we found that the seronegativity rate was 9.7% for primiparous women who had been vaccinated with the RA 27/3 strain 22 years ago.…”

Section: Discussionmentioning

confidence: 99%

Persistence and Titer Changes of Rubella Virus Antibodies in Primiparous Women Who Had Been Vaccinated with Strain RA 27/3 in Junior High School

Lin

Yang

Shih

et al. 2012

Clin Vaccine Immunol

View full text Add to dashboard Cite

Taiwan's rubella vaccination program was launched in 1986; each schoolgirl in the third grade of junior high school received one dose of rubella (RA 27/3) vaccine. We reviewed the results of 14,090 prenatal rubella tests for primiparas from three areas of Taiwan during 2002 to 2008 to investigate seronegativity rates and titer changes. In all primiparous women, the average rubella virus seronegativity rate was 6.5% (95% confidence interval [95% CI], 6.1 to 6.9%), and the average rubella virus antibody titer was 65.9 IU/ml (95% CI, 64.7 to 67.1 IU/ml). There were 1,220 women (8.7%) with weakly positive antibody titers (10 to 20 IU/ml). The rubella virus seronegativity rates, which ranged from 5.4 to 9.7%, did not exhibit a linear trend from 9 to 22 years after vaccination (P ‫؍‬ 0.201); in contrast, a significant trend appeared in the average rubella virus IgG titer (P ‫؍‬ 0.003), dropping from 69.9 IU/ml in the 9th year after vaccination to 54.8 IU/ml in the 22nd year. The mean annual antibody decay rate was ؊0.77 IU/ml. This study reveals that the level of rubella virus antibodies declined slowly in women of childbearing age who were vaccinated with RA 27/3 at junior high school age. The number of women who were seronegative or had weakly positive antibody titers was still high (15.2%). Therefore, in countries that implement a single-dose regimen in children or teenagers, it should remain an important policy to encourage voluntary immunization in seronegative women and to immunize all postpartum women who are susceptible to rubella virus infection before they leave the hospital.

show abstract

Section: Discussionmentioning

confidence: 99%

Persistence and Titer Changes of Rubella Virus Antibodies in Primiparous Women Who Had Been Vaccinated with Strain RA 27/3 in Junior High School

Lin

Yang

Shih

et al. 2012

Clin Vaccine Immunol

View full text Add to dashboard Cite

show abstract

“…While humoral responses have been conventionally used to measure protective immunity, cellular immune responses provide a crucial counterpart to humoral immunity (3,8,13,23), but have not been well studied in the case of rubella (1,2,10,18-22,37,38). Investigators pursuing novel vaccines have raised the importance of cell-mediated immunity (CMI) in protection from rubella infection.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Rubella Antibody Levels and Cytokine Measures of Cell-Mediated Immunity

et al. 2009

View full text Add to dashboard Cite

Despite a safe and effective vaccine, endemic rubella remains a problem in developing countries. Isolated cases and outbreaks can occur in areas with high vaccine coverage. Individuals, especially pregnant women who remain unimmunized or do not seroconvert, are susceptible to infection and their infants are at risk for congenital rubella syndrome (CRS). Both humoral and cellular immune responses contribute to immune protection. Classically, immunity to rubella has been assessed through the detection of rubella-specific antibody titers. In this study we examined correlates of both humoral and cellular immunity in a large population of immunized young adults in Olmsted County, MN. We were unable to find any significant correlation between cytokine production after in-vitro rubella stimulation and serum antibody titers.

show abstract

“…RA 27/3 strain showed a good immunogenicity and is reported to be a better immunogen than other rubella live attenuated vaccines [21,22]. All the vaccinees showed a vaccine-induced seroconversion evaluated by HAI and NT antibodies as soon as one month after vaccination.…”

Section: Discussionmentioning

confidence: 93%

Immune responses to wild and vaccine rubella viruses after rubella vaccination

Cusi

Metelli

Valensin

1989

Archives of Virology

View full text Add to dashboard Cite

Antibody responses to individual structural proteins (E1, E2, and C) of the M33 wild rubella virus and the RA 27/3 live attenuated rubella strain were assayed by immunoblotting in 11 girls, following immunization with RA 27/3 rubella vaccine. Serum samples were drawn before immunization and at 10 days, 1 month, 1 year, 2 years, and 3 years afterwards. All the subjects showed antibodies to E1 glycoprotein of both the virus strains up to three years after immunization, indicating the importance of E1 in immunity. Antibodies to E1 were always present when with neutralizing activity was observed. Antibodies to E2 protein of both the viruses and to the C protein of the M33 virus gradually disappeared with time in some samples, while antibodies to C protein of the RA 27/3 virus strain were found persistently in all the sera.

show abstract

Persistence of Vaccine-Induced Immune Responses to Rubella: Comparison with Natural Infection

Cited by 68 publications

References 12 publications

Persistence and Titer Changes of Rubella Virus Antibodies in Primiparous Women Who Had Been Vaccinated with Strain RA 27/3 in Junior High School

Persistence and Titer Changes of Rubella Virus Antibodies in Primiparous Women Who Had Been Vaccinated with Strain RA 27/3 in Junior High School

Correlation Between Rubella Antibody Levels and Cytokine Measures of Cell-Mediated Immunity

Immune responses to wild and vaccine rubella viruses after rubella vaccination

Contact Info

Product

Resources

About