Persistence of vitamin D deficiency among Italian patients with acute myocardial infarction

Aleksova, Aneta; Janjusevic, Milijana; Zhou, Xin Ning Oriana; Zandonà, Lorenzo; Chicco, Andrea; Stenner, Elisabetta; Beltrami, Antonio Paolo; D'Errico, Stefano; Sinagra, Gianfranco; Marketou, Maria; Fluca, Alessandra Lucia; Zwas, Donna R.

doi:10.1016/j.numecd.2024.02.007

Cited by 3 publications

References 45 publications

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Exploring Vitamin D Synthesis and Function in Cardiovascular Health: A Narrative Review

Aiello,

Lombardo,

Baldelli

2024

Applied Sciences

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Vitamin D plays a crucial role in the human body, influencing a wide range of physiological processes from bone health to immune function. The complex biochemical pathways involved in the synthesis, metabolism, and action of Vitamin D are explored, emphasizing its importance in nutrition and food technology. This review also investigates the regulatory mechanisms that control Vitamin D metabolism and its systemic effects on calcium homeostasis, cell proliferation, differentiation, and immune modulation. The role of Vitamin D3 in regulating blood pressure and atherosclerosis in the onset of cardiovascular disorders is discussed. Given the importance of Vitamin D in food science and technology, the regulatory mechanisms that control Vitamin D metabolism and its systemic effects on calcium homeostasis are also investigated, integrating innovative approaches and advanced technologies to improve human health through nutrition. Additionally, the review assesses the influence of food processing on Vitamin D levels and discusses cutting-edge technologies as innovative strategies to mitigate Vitamin D loss during food processing. This comprehensive exploration aims to improve our understanding of the biochemical pathways of Vitamin D and its relevance to food science, contributing to the development of new strategies for food fortification and the promotion of optimal health through diet.

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Exploring Vitamin D Synthesis and Function in Cardiovascular Health: A Narrative Review

Aiello,

Lombardo,

Baldelli

2024

Applied Sciences

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The Co-Existence of Hypovitaminosis D and Diabetes Mellitus Triples the Incidence of Severe Coronary Artery Disease in Women

Aleksova,

Janjusevic,

Pani

et al. 2024

JCM

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Background and Aims: Hypovitaminosis D is involved in the development and progression of atherosclerosis, and it is more prevalent in women. The differential impact of hypovitaminosis D on the severity of coronary artery disease (CAD) between genders remains poorly understood. This study aims to address this literature gap. Methods: A total of 1484 consecutive patients with acute myocardial infarction (AMI) were enrolled in the study. Hypovitaminosis D was defined as vitamin D ≤ 20 ng/mL. CAD was defined as the presence of at least one coronary vessel stenosis > 50%, while severe CAD was defined as left main disease and/or three-vessel disease > 50%. Results: The mean age of the cohort was 66.3 (11.5) years, with a predominance of the male gender (71.8%). Vitamin D values were significantly lower in women than in men (15.7 [8.4–25.4] ng/mL vs. 17.9 [11–24.3] ng/mL, p = 0.01). A higher prevalence of severe CAD was observed in female patients with hypovitaminosis D compared to those without (33% vs. 19%, p < 0.01). This finding was not observed in men. Among women, hypovitaminosis D significantly increased the risk of severe CAD (OR: 1.85, p = 0.01), together with diabetes mellitus (DM) and older age, adjusted for GFR < 60 mL/min/1.73 m2, cholesterol and body mass index. Furthermore, women with both hypovitaminosis D and DM had more than three times the risk of severe CAD compared with women who lacked both (OR: 3.56, p = 0.02). Conclusions: In women, hypovitaminosis D increases the risk of severe CAD, and the co-existence of hypovitaminosis D and DM triples the incidence of severe CAD.

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Vitamin D and Cardiovascular Health: Benefits and Controversies of Supplementation

Aleksova,

Lucia Fluca,

Sinagra

et al. 2024

Recent Studies on Vitaminology - Insights, Applications and Uses [Working Title]

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Vitamin D is a steroid hormone that exerts pleiotropic effects in the cardiovascular field, including the protection of endothelial function, the control of inflammation, the regulation of intracellular calcium homeostasis, and the modulation of the renin-angiotensin-aldosterone system (RAAS). Hypovitaminosis D, defined as vitamin D ≤ 20 ng/mL, is frequently associated with hypertension, the development of heart failure, and higher morbidity and mortality after a myocardial infarction (MI). Despite initial enthusiasm regarding the potential benefits of vitamin D supplementation in the management of cardiovascular diseases (CVDs), recent clinical trials have yielded contrasting results regarding its effectiveness in a clinical setting. Consequently, the benefits of vitamin D in CVDs are currently called into question. This chapter aims to describe the physiological effects of vitamin D on cardiovascular health and the current data on its supplementation in patients with CVDs.

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Persistence of vitamin D deficiency among Italian patients with acute myocardial infarction

Cited by 3 publications

References 45 publications

Exploring Vitamin D Synthesis and Function in Cardiovascular Health: A Narrative Review

Exploring Vitamin D Synthesis and Function in Cardiovascular Health: A Narrative Review

The Co-Existence of Hypovitaminosis D and Diabetes Mellitus Triples the Incidence of Severe Coronary Artery Disease in Women

Vitamin D and Cardiovascular Health: Benefits and Controversies of Supplementation

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