Persistence, prevalence, and polymorphism of sequelae after COVID-19 in unvaccinated, young adults of the Swiss Armed Forces: a longitudinal, cohort study (LoCoMo)

Deuel, Jeremy; Lauria, Elisa; Lovey, Thibault; Zweifel, Sandrine; Meier, Mara Isabella; Züst, Roland; Gültekin, Nejla; Stettbacher, Andreas; Schlagenhauf, Patricia

doi:10.1016/s1473-3099(22)00449-2

Cited by 19 publications

(22 citation statements)

References 28 publications

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“… 5 Although total cholesterol, LDL cholesterol, and HDL cholesterol are often reduced during the acute phase of SARS-CoV-2 infection, emerging evidence from small observational studies with short follow-ups (of up to 6 months) suggest increased risk of dyslipidaemia in the post-acute phase of COVID-19. 4 , 5 , 6 , 7 , 8 , 9 A study of 501 young adults (aged 18–30 days) of the Swiss Armed Forces showed that compared with non-infected controls, those with COVID-19 had a higher blood cholesterol and LDL concentrations 180 days after their first positive PCR test. 8 A large observational study of more than 2 million people of all ages with COVID-19 from FAIR Health, with no control group, reported that approximately 3% developed dyslipidaemia after the first 30 days of infection.…”

Section: Introductionmentioning

confidence: 99%

“… 4 , 5 , 6 , 7 , 8 , 9 A study of 501 young adults (aged 18–30 days) of the Swiss Armed Forces showed that compared with non-infected controls, those with COVID-19 had a higher blood cholesterol and LDL concentrations 180 days after their first positive PCR test. 8 A large observational study of more than 2 million people of all ages with COVID-19 from FAIR Health, with no control group, reported that approximately 3% developed dyslipidaemia after the first 30 days of infection. 9 Together, these observations suggest the hypothesis that SARS-CoV-2 infection is associated with increased risk of post-acute dyslipidaemia.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Risks and burdens of incident dyslipidaemia in long COVID: a cohort study

Xie

Al‐Aly

2023

The Lancet Diabetes & Endocrinology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risks and burdens of incident dyslipidaemia in long COVID: a cohort study

Xie

Al‐Aly

2023

The Lancet Diabetes & Endocrinology

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“…We will now review the main studies that support what is currently known on this topic. In a recent study [ 68 ], multi-organ function was assessed by a series of sensitive and minimally invasive tests in a group of subjects several months after COVID-19. The interesting thing about the study was the control group: the control group was shown by a confirmatory serological test to have had no exposure to SARS-CoV-2, unlike other studies that looked at general health.…”

Section: Post-covid-19 Syndromementioning

confidence: 99%

“…The interesting thing about the study was the control group: the control group was shown by a confirmatory serological test to have had no exposure to SARS-CoV-2, unlike other studies that looked at general health. The study [ 68 ] focused on organ function, i.e., cardiovascular function, pulmonary function, neurological function, ophthalmological function, male fertility and psychological aspects, using a battery of innovative tests in a clinical setting rather than online or using telephone surveys or database analysis. The study also adds to the evidence on the spectrum and persistence of COVID-19 sequelae in previously healthy young adults.…”

Section: Post-covid-19 Syndromementioning

confidence: 99%

Unfavorable Outcome and Long-Term Sequelae in Cases with Severe COVID-19

Fabbri

Voza

Riccardi

et al. 2023

Viruses

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Emerging evidence shows that individuals with COVID-19 who survive the acute phase of illness may experience lingering symptoms in the following months. There is no clear indication as to whether these symptoms persist for a short time before resolving or if they persist for a long time. In this review, we will describe the symptoms that persist over time and possible predictors in the acute phase that indicate long-term persistence. Based on the literature available to date, fatigue/weakness, dyspnea, arthromyalgia, depression, anxiety, memory loss, slowing down, difficulty concentrating and insomnia are the most commonly reported persistent long-term symptoms. The extent and persistence of these in long-term follow-up is not clear as there are still no quality studies available. The evidence available today indicates that female subjects and those with a more severe initial disease are more likely to suffer permanent sequelae one year after the acute phase. To understand these complications, and to experiment with interventions and treatments for those at greater risk, we must first understand the physio-pathological mechanisms that sustain them.

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“…8 SARS-CoV-2 infection has been also associated with long-term changes in brain structure according to a UK Biobank study. 9 In this context, the study by Jeremy Werner Deuel and colleagues, 10 reported in The Lancet Infectious Diseases, explores sequelae after SARS-CoV-2 infection in young adults (median age 21 years [IQR 21-23]). Deuel and colleagues did a longitudinal cohort study of 501 mainly young male adults (464 [93%]) undertaking a comprehensive test battery designed to evaluate physical and psychosocial outcomes after COVID-19.…”

mentioning

confidence: 99%