Persistence with statin therapy in Hungary

Kiss, Zoltán; Nagy, László; Rácz, I; Paragh, György; Molnár, Márk Péter; Rokszin, György; Abonyi‐Tóth, Zsolt; Márk, László

doi:10.5114/aoms.2013.35327

Cited by 23 publications

(20 citation statements)

References 43 publications

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“…The fact that forgetfulness was more common for hyperlipidemia patients could possibly be explained by the consequences of the condition not being perceived as significant. Additionally, in this class a high proportion reported having stopped because they had run out of medication, consistent with previous literature [39]. Careless behaviour was more often reported by patients with diabetes, which seems logical as this therapeutic class generally requires more daily administrations in comparison with the other therapeutic groups studied.…”

Section: Discussionsupporting

confidence: 88%

Primary non-adherence in Portugal: findings and implications

Costa

Pedro²,

Teixeira

et al. 2015

Int J Clin Pharm

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Background Portugal is currently facing a serious economic and financial crisis, which is dictating some important changes in the health care sector. Some of these measures may potentially influence patients' access to medication and consequently adherence, which will ultimately impact on health status, especially in chronic patients. Aims This study aimed at providing a snapshot of adherence in patients with chronic conditions in Portugal between March and April 2012. Setting Community pharmacy in Portugal. Method A cross-sectional pilot study was undertaken, where patients were recruited via community pharmacies to a questionnaire study evaluating the number of prescribed and purchased drugs and, when these figures were inconsistent, the reasons for this. Main outcome measures Primary and secondary adherence measures. Failing to purchase prescription items was categorized as primary nonadherence. Secondary nonadherence was attributed to purchasing prescription items, but not taking medicines as prescribed. Results Data were collected from 375 patients. Primary nonadherence was identified in 22.8 % of patients. Regardless of the underlying condition, the most commonly reported reason for primary non-adherence was having spare medicines at home (''leftovers''), followed by financial problems. The latter appeared to be related to the class of medicines prescribed. Primary nonadherence was associated with low income (\475 €/month; p = 0.026). Secondary non-adherence, assessed by the 7-MMAS was detected in over 50 % of all patients, where unintentional nonadherence was higher than intentional nonadherence across all disease conditions. Conclusion This study revealed that more than one fifth of chronic medication users report primary nonadherence (22.8 %)A very short-version of this work was included in the Annual Report 2012 of the Portuguese Observatory of Health Systems. and more than 50 % report secondary nonadherence. Data indicates that the existence of spare medicines and financial constraints occurred were the two most frequent reasons cited for nonadherence (47, 6-64, 8 and 19-45.5 %, depending on the major underlying condition, respectively). Electronic supplementary material

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Section: Discussionsupporting

confidence: 88%

Primary non-adherence in Portugal: findings and implications

Costa

Pedro²,

Teixeira

et al. 2015

Int J Clin Pharm

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“…17 Overall, statin persistence in our population was greater than that reported in other populations. 17,18 With regard to risk of developing psychological and cognitive disorders in relation to statin persistence, our outcome data showed that nonpersistent statin users had a greater risk of being diagnosed with schizophrenia/psychosis (psych 1) and cognitive disorders (psych 4) compared with persistent users. The interpretation of these results can be challenging.…”

Section: 16mentioning

confidence: 97%

Comparison of the Risk of Psychological and Cognitive Disorders Between Persistent and Nonpersistent Statin Users

Lilly

Mortensen

Frei

et al. 2014

The American Journal of Cardiology

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Despite their cardiovascular benefits, statin use has been associated with a wide array of actual or perceived psychological and cognitive adverse events. The objective of this study was to compare baseline characteristics and the risk of developing psychological and cognitive disorders between persistent and nonpersistent statin users. We performed a retrospective cohort study (October 1, 2003, to March 1, 2010 of 13,626 statin users in a regional US military health-care system. The persistence of statin use was defined by cumulative pharmacy fill data. Outcomes were the occurrence of psychological diseases during follow-up using prespecified groups based on International Classification of Diseases, Ninth Revision, codes: (1) schizophrenia and psychosis, (2) major depression and bipolar disorders, (3) all psychological diseases, and (4) dementia and cognitive disorders. Statin users who were nonpersistent at 2 years were younger, less likely to be men, and had fewer co-morbidities than persistent users. They were also more likely to be diagnosed with schizophrenia or psychosis (odds ratio [OR] 1.58, 95% confidence interval [CI] 1.20 to 2.10) and cognitive disorders (OR 1.56, 95% CI 1.19 to 2.03) during follow-up compared with persistent users. There was not an association between nonpersistence at 2 years and the development of depression and bipolar disorders (OR 0.99, 95% CI 0.85 to 1.15) or combined psychological diseases (OR 0.97, 95% CI 0.86 to 1.09). Cumulative persistence with statin therapy as a continuous measure was associated with less risk of all outcomes. In conclusion, persistent statin users did not demonstrate an increase in the diagnosis of psychological disorders compared with nonpersistent users. Nonpersistent statin use was associated with a greater likelihood of being diagnosed with psychotic or cognitive disorders. Published by Elsevier Inc. (Am J Cardiol 2014;114:1035e1039) Several conflicting reports have examined the association of statins (hydroxymethylglutaryl coenzyme-A reductase inhibitors) and the risk of psychological and cognitive disorders. 1e4 Beyond the issue of whether statin use is associated with psychological side effects, the relation between persistence with statin therapy and the development of these disorders is unclear. Understanding such a relation, if one exists, is important for both providers and patients to improve guideline-based adherence to statin therapy. To our knowledge, no cohort or randomized controlled study has compared the prevalence of psychological disorders in statin users based on patient persistence with therapy.

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“…Többek között a fiatalkorban észlelt rosszabb terápiás együttműködés is hozzájárulhat e korcsoport magasabb kardiovaszkuláris kockázatához, 14…”

Section: A Kardiovaszkuláris éS a Mortalitási Kockázat Korfüggőségeunclassified

A 2-es típusú cukorbetegség kardiovaszkuláris megbetegedésre és összmortalitásra kifejtett korfüggő hatása: országos elemzés a NEAK adatbázisa alapján

Kiss¹,

Rokszin²,

Abonyi‐Tóth³

et al. 2019

Diabetologia Hungarica

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A 2-es típusú cukorbetegség halálozási és kardiovaszkuláris morbiditásának magasabb kockázata jól ismert. Országos, retrospektív vizsgálatunkban a T2DM-es betegek halálozási, myocardialis infarktus és stroke-kockázatát értékeltük kontrollcsoport tükrében. A Nemzeti Egészségbiztosítási Alap (NEAK) adatbázisán alapuló retrospektív kohorsz-vizsgálatunkba a 2010. január 1. és 2013. december 31. között újonnan antidiabetikus kezelésben részesülő T2DM-es betegeket vontuk be. Minden T2DM-es beteghez életkor, nem, illetve a lakóhely irányítószáma szerint két kontrollt illesztettünk.

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Persistence with statin therapy in Hungary

Cited by 23 publications

References 43 publications

Primary non-adherence in Portugal: findings and implications

Primary non-adherence in Portugal: findings and implications

Comparison of the Risk of Psychological and Cognitive Disorders Between Persistent and Nonpersistent Statin Users

A 2-es típusú cukorbetegség kardiovaszkuláris megbetegedésre és összmortalitásra kifejtett korfüggő hatása: országos elemzés a NEAK adatbázisa alapján

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