Persistent agmination of lymphomatoid papulosis evolving to classical lesions of lymphomatoid papulosis

Romero‐Maté, Alberto; Martín-Fragueiro, Luz; Medrano, R. Miñano; Martínez‐Morán, C.; Arias-Palomo, Dolores; Borbujo, J.

doi:10.1016/j.jaad.2008.12.018

Cited by 10 publications

(15 citation statements)

References 5 publications

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“…Based on the above, our case fulfills the description given by Heald et al [2]. However, at difference from it and in keeping with that observed by Romero-Maté et al [4], it involved multiple sites. This questions the objection that PALP may represent a form of localized LyP.…”

Section: Discussionsupporting

confidence: 90%

“…Since then, it has been the object of four additional reports, at times contradictory to each other [3,4,5,6] (see tables 1 and 2 for the criteria of the entity and for a summary of the reported cases). In particular, Heald et al [2] described 7 patients who showed persistent localized eruptions of papulonodules waxing and waning but often not resolving completely, present from 5 months to 12 years.…”

Section: Discussionmentioning

confidence: 99%

“…A few months later, Steinhoff et al [3] questioned that PALP merits an autonomous recognition by likely representing a localized form of LyP. Almost at the same time, two new cases were reported by Romero-Maté et al [4] and Torrelo et al [5]. The former was recorded in a 27-year-old male with a 4-month history of several asymptomatic stable nodules that appeared on the right thigh within a 15-cm erythematous, scaly, noninfiltrated patch.…”

Section: Discussionmentioning

confidence: 99%

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Persistent Agmination of Lymphomatoid Papulosis: An Ongoing Debate

Pileri

Bacci²,

Neri³

et al. 2012

Dermatology

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Background: Persistent agmination of lymphomatoid papulosis (PALP) has been a matter of controversy in the literature, some authors suggesting that it represents composite lymphoma, others localized lymphomatoid papulosis (LyP). Patient and Methods: A 64-year-old man was referred to our outpatient center complaining of papular eruptions lasting 3 years. At physical examination, he showed papulonodular lesions on the trunk and extremities. Some patches on the trunk and upper arms were also observed. Both types of lesion were biopsied and studied on histological, immunohistochemical and molecular grounds. Results: The nodular lesion revealed the classical features of LyP type A, while the patch was characterized by the presence of a superficial and deep infiltrate with perivascular and interstitial location, consisting of mature lymphocytes admixed with plasma cells and large atypical cells that became more numerous beneath the epidermis. On immunohistochemistry the two lesions presented the same profile. Conclusion: Our case suggests that PALP does not correspond to localized LyP, as it can involve different skin areas since its presentation. Furthermore it rules out the possibility that PALP is a composite lymphoma. In fact, the same cytological and phenotypic characteristics were detected in all samples, including those taken from patchy areas.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Persistent Agmination of Lymphomatoid Papulosis: An Ongoing Debate

Pileri

Bacci²,

Neri³

et al. 2012

Dermatology

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“…Evidence in support of this hypothesis includes LyP lesions tend to be larger (papules or nodules up to 2 cm diameter), more persistent and may form plaque-like clusters resembling MF, whereas PL lesions tend to be smaller (pustules or papules) and disseminated. 16,[23][24][25][26][27] The histologic features of LyP-A (large atypical CD30+ cells with admixed neutrophils and/or eosinophils in the dermal infiltrate) are easily differentiated from PLEVA (absence of atypical CD30+ cells with few if any admixed neutrophils or eosinophils). [28][29][30] In addition, the large atypical cells of LyP-A often have an abnormal DNA content or chromosomes, whereas the cells of PL are normal.…”

Section: Discussionmentioning

confidence: 99%

Lymphomatoid Papulosis Followed by Pityriasis Lichenoides: A Common Pathogenesis?

Vonderheid¹,

Kadin²,

Gocke³

2011

The American Journal of Dermatopathology

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Pityriasis lichenoides (PL) and lymphomatoid papulosis (LyP) are uncommon idiopathic eruptions with overlapping clinical and histological features. Although current opinion indicates that PL and LyP are distinct and separate entities, molecular genetic evidence of T-cell clonality in both conditions suggests that an etiopathogenic relationship may exist. We report a patient who was diagnosed with LyP type B in 1985 followed by PL after 11 years. We hypothesize that LyP followed by PL in the same patient reflects differences in the host immune response to a common antigenic stimulus.

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“…Moreover, the comprehensible idea of some authors that PALP simply reflects localized LyP has been recently questioned by Pileri et al [22], who reported a patient presenting with simultaneous patch areas as well as waxing and waning papulonodular lesions on the trunk and extremities, both manifestations characterized as LyP. Finally, further cases of PALP are on record that showed spontaneous remission as in typical LyP [18,23,24], suggesting that the patch- and plaque-like features of PALP belong to the LyP component of the lesion. Altogether, PALP apparently shares all the clinicopathological features that have also been described for regional, but just in part for classical, LyP (table 1).…”

Section: Discussionmentioning

confidence: 99%

A Case of Lymphomatoid Papulosis Limited to Becker's Melanosis

Buder

Wendel²,

Cerroni³

et al. 2013

Dermatology

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Regional lymphomatoid papulosis (LyP) accounts for 2-27% of all LyP cases. Several localized dermatoses have been reported in association with Becker's melanosis (BM), e.g. acneiform lesions or lichen planus. Here, we report on regional LyP confined to the area of BM. A 56-year-old man presented with a 1-year history of a steadily increasing number of multiple pruritic red papules developing on the area of BM, which had occurred on his left shoulder during puberty. Histopathological analysis was consistent with regional LyP. Potent topical steroids followed by oral doxycycline did not achieve improvement, while long-term oral bexarotene treatment ameliorated the skin condition. Recently, the proposed entity of ‘persistent agmination of LyP' (PALP) has extended the clinicopathological observations of regional LyP. Since PALP remains controversial, a unifying concept of localized LyP and PALP will be discussed.

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Persistent agmination of lymphomatoid papulosis evolving to classical lesions of lymphomatoid papulosis

Cited by 10 publications

References 5 publications

Persistent Agmination of Lymphomatoid Papulosis: An Ongoing Debate

Persistent Agmination of Lymphomatoid Papulosis: An Ongoing Debate

Lymphomatoid Papulosis Followed by Pityriasis Lichenoides: A Common Pathogenesis?

A Case of Lymphomatoid Papulosis Limited to Becker's Melanosis

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