Persistent Arthralgia Associated with Chikungunya Virus Outbreak, US Virgin Islands, December 2014–February 2016

Feldstein, Leora R.; Rowhani-Rahbar, Ali; Staples, J. Erin; Weaver, Marcia R.; Halloran, M. Elizabeth; Ellis, Esther M.

doi:10.3201/eid2304.161562

Cited by 37 publications

(34 citation statements)

References 12 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Only rare community-based prospective studies were found to be reported in the scientific literature concerning insular Caribbean populations. [36][37][38][39][40][41] In other world regions, past exploratory research on chronicity was conducted either prospectively on hospitalized and circumscribed patient samples or retrospectively amidst the general population. 5,[12][13][14] In light of the emerging public health burden of CHIK disease for the Caribbean region and the Americas, the present study aims mainly to provide a more comprehensive description of the epidemiological characteristics and health outcomes of chronic stage CHIK cases in the general population of Martinique.…”

Section: Discussionmentioning

confidence: 99%

“…best knowledge, the Martinique study is the only one to examine longitudinally such a large cohort of participants (N = 509), with a broad geographical assessment of the study population all over the island (recruiting GPs were located in different areas of the territory). [36][37][38][39][40][41] The approach to gathering late illness symptoms and QoL attributes (diverse range of physical and psychological health outcomes) has also been rarely conducted by other research teams. However, less than half of the eligible subjects identified by GPs finally participated in the follow-up phase, with 705 participants (58.1%) lost to follow-up between the initial recruitment and the followup phases.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Occurrence of Chronic Stage Chikungunya in the General Population of Martinique during the First 2014 Epidemic: A Prospective Epidemiological Study

Couzigou

Criquet-Hayot

Javelle

et al. 2018

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Chronic stage chikungunya (CHIK), defined by persisting symptoms more than 3 months after initial diagnosis of acute infection, is frequent. However, its burden and impact have rarely been described prospectively in a general population during an ongoing epidemic in the Caribbean. From January 2014 to January 2015, a severe CHIK outbreak occurred in Martinique. Our objective was to describe epidemiological characteristics and outcomes of chronic stage CHIK in its local population. Participants, clinically diagnosed with probable CHIK infection, were included prospectively by general practitioners during the epidemic's peak from April to October 2014. All identified cases benefited from a follow-up phone call 3 months or more after initial diagnosis during which they were interrogated about persisting clinical signs, past and ongoing treatment, and quality of life. Five hundred and nine subjects participated in the study. Mean age at initial diagnosis was 43.2 ± 23.6 years with a female-male ratio of 1.98. Two hundred participants (39.3%) had probable chronic stage CHIK: 98.5% still experienced pain at least 3 months after acute infection, with 84.3% of reported joint pains; 21.2% were woken up by the pain; 47.2% felt depressed/anxious; and 31.3% experienced memory/concentration disorders. Resumption of daily activity and work was complicated for 55.8% and 36.2% of cases. Persistent impact on morbidity, health outcomes, psychological, and economic aspects further underline the crucial role of community-based medicine and the necessity of an evidence-based multidisciplinary approach toward chronic stage CHIK identification, management, and follow-up in this particular world region.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Occurrence of Chronic Stage Chikungunya in the General Population of Martinique during the First 2014 Epidemic: A Prospective Epidemiological Study

Couzigou

Criquet-Hayot

Javelle

et al. 2018

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…Most patients with arbovirus infections present with nonspecific signs and symptoms (Feldstein et al, 2017;Mejía and López-Vélez, 2018;Muller et al, 2017) similar to those associated with malaria, typhoid, and other bacterial infections. In Sub-Saharan Africa, arbovirus infections are often unreported, undiagnosed, or misdiagnosed and treated presumptively as malaria or typhoid.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of yellow fever, dengue, West Nile and chikungunya viruses in children in Teso South Sub-County, Western Kenya

Inziani

Adungo

Awando

et al. 2020

International Journal of Infectious Diseases

View full text Add to dashboard Cite

Background: Arboviruses often cause widespread morbidity in children in endemic regions. Data on the burden of arboviruses in Kenyan children are limited. Objectives: This study was performed to determine the seroprevalence of yellow fever (YFV), dengue (DENV), West Nile (WNV), and chikungunya (CHIKV) viruses among children 1-12 years of age at two health facilities in Teso South Sub-County in Western Kenya. Methods: In a hospital-based cross-sectional survey, a questionnaire was used to collect sociodemographic information. Serum drawn from the children was tested for IgA/IgM/IgG serocomplex antibodies to selected arboviruses using indirect ELISA and plaque reduction neutralization tests. Results: A total of 182 (27.7%) of the 656 participants tested were positive for any arbovirus antibody. Of these, 4.4% (29/656) tested positive for YFV, 9.6% (62/649) for WNV, 5.6% (36/649) for CHIKV, 1.4% (5/368) for DENV1, 9% (59/656) for DENV2, and 19.7% (40/203) for DENV3. Neutralizing antibodies to CHIKV were found in 77.8% (42/54) of participants, to YFV in 15.8% (3/19), to DENV2 in 58% (29/50), and to WNV in 8% (1/55). Sex, age, urban residence, schooling, and lack of vaccination were associated with arbovirus exposure. Conclusions: This study confirmed that children under 12 years of age in Teso South Sub-County are exposed to ongoing arbovirus infections early in life.

show abstract

“…The characteristics and consequences of CHIKV infection in Caribbean populations have been described (5,(12)(13)(14). However, only two English-speaking Caribbean countries [US Virgin Islands (USVI) and Jamaica] have published reports of the infection (15)(16)(17). Duncan et al highlighted the clinical presentation of CHIKV illness during the acute phase of the disease in Jamaica (17).…”

Section: Introductionmentioning

confidence: 99%

Chikungunya Virus Infection-associated Arthralgia in Adult Jamaicans Post-outbreak

O’Sullivan¹,

Campbell²,

Darby³

et al. 2018

West Indian Med J

View full text Add to dashboard Cite

Objective: To report demographic and self-reported clinical characteristics associated with persistent and severe arthralgia 8–12 months post-chikungunya virus (CHIKV) infection. Methods: A cross-sectional study of 306 adults who self-reported CHIKV infection was conducted. Subjects were consecutively enrolled at public primary healthcare centres in urban and rural areas in Jamaica. Adults with arthralgic conditions were compared with those who reported no arthralgia. Binary logistic regression models were used to determine demographic and self-reported clinical factors associated with severe arthralgia and persistent arthralgia. Results: Most subjects (70.3%) reported arthralgia after CHIKV outbreak (age: 47.6 ± 18.5 years). Medical consultation (36.2%) and laboratory confirmation (1.4%) were low. The prevalence of persistent and severe arthralgia in the previous month was 30.3% and 27.5%, respectively. Severe arthralgia was associated with the female gender (odds ratio (OR): 2.44; 95% confidence level (CI): 1.08, 5.52) and pre-existing arthritis (OR: 3.78; 95% CI: 1.23, 11.62). Females showed a greater likelihood of persistent arthralgia (OR: 2.18; 95% CI: 1.09, 4.39). Conclusion: Self-perceived arthralgia was an important feature 8–12 months post-CHIKV infection and has implications for the recognition and management of arthritis/rheumatic conditions.

show abstract

Persistent Arthralgia Associated with Chikungunya Virus Outbreak, US Virgin Islands, December 2014–February 2016

Cited by 37 publications

References 12 publications

Occurrence of Chronic Stage Chikungunya in the General Population of Martinique during the First 2014 Epidemic: A Prospective Epidemiological Study

Occurrence of Chronic Stage Chikungunya in the General Population of Martinique during the First 2014 Epidemic: A Prospective Epidemiological Study

Seroprevalence of yellow fever, dengue, West Nile and chikungunya viruses in children in Teso South Sub-County, Western Kenya

Chikungunya Virus Infection-associated Arthralgia in Adult Jamaicans Post-outbreak

Contact Info

Product

Resources

About